Featured Research

from universities, journals, and other organizations

Researchers Unlock How Cells Determine Their Functions

Date:
February 27, 2006
Source:
University of California - Riverside
Summary:
Researchers at the University of California, Riverside have discovered a molecular mechanism directing the fate and function of cells during animal development. The findings could hold promise for the advancement of cancer and stem-cell research.

At left is a schematic showing how the Ash1 epigenetic activator interacts with the DNA of the fruit fly drosophila. At right is Ultrabithorax expression in the fruit fly wing.
Credit: Image courtesy of University of California - Riverside

Researchers at the University of California, Riverside have discovered a molecular mechanism that directs the fate and function of cells during animal development. The findings could hold promise for the advancement of cancer and stem-cell research.

Related Articles


The research is published in the Feb. 24 edition of the journal Science. UCR Biochemistry Professor Frank Sauer, with German colleague Elisabeth Kremmer of the Institut für Molekulare Immunologie in Munich, and fellow UCR researchers Tilman Sanchez-Elsner and Dawei Gou authored the paper titled, Noncoding RNAs of Trithorax Response Elements Recruit Dosphila Ash1 to Ultrabithorax.
The paper explains how proteins, known as epigenetic activators (such as Ash1 from the fruit fly Drosophila), bind to their target DNA and activate genes that determine what function a cell will have in the body.

“The fact that these epigenetic activators, such as Ash1, turn on the expression of specific target genes has been known for some time. However, the mechanisms by which epigenetic activators recognize and bind these target genes was not yet known” Sauer pointed out.

“What we were able to show is that the epigenetic activator Ash1is recruited to a target gene through cell-type specific non-coding RNA” he said.

The paper examined how the activator Ash1 binds to target DNA elements, known as Trithorax-reponse elements (TREs), located in the gene Ultrabithorax (Ubx). Non-coding RNA is produced by and retained at the TREs of Ubx, and helps activate the expression of the Ubx gene by attracting Ash1 to the TREs. The transgenic transcription of non-coding TRE RNA can change the type and function of cells.

“As a result, we can now use non-coding RNAs as tools to actively determine cell fate,” Sauer said.

“Over the last few years, researchers have focused on how noncoding RNAs silence genes,” said Anthony Carter, of the National Institute of General Medical Sciences, which partially funded the research. “Dr. Sauer’s work has revealed that noncoding RNAs have a broader range of functions than was previously known, and suggests a model for how they can help activate, rather than silence, a key regulator of animal development.”

The research was funded in part through the National Institute of General Medical Sciences at the National Institutes of Health in Bethesda, Md, the Volkswagen Stiftung of Hannover, Germany, Deutsche Forschungsgenmeinschaft (DFG) Transregio 5 and a Postdoctoral fellowship from the (DFG).


Story Source:

The above story is based on materials provided by University of California - Riverside. Note: Materials may be edited for content and length.


Cite This Page:

University of California - Riverside. "Researchers Unlock How Cells Determine Their Functions." ScienceDaily. ScienceDaily, 27 February 2006. <www.sciencedaily.com/releases/2006/02/060227184539.htm>.
University of California - Riverside. (2006, February 27). Researchers Unlock How Cells Determine Their Functions. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2006/02/060227184539.htm
University of California - Riverside. "Researchers Unlock How Cells Determine Their Functions." ScienceDaily. www.sciencedaily.com/releases/2006/02/060227184539.htm (accessed October 24, 2014).

Share This



More Health & Medicine News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Breakfast Debate: To Eat Or Not To Eat?

Breakfast Debate: To Eat Or Not To Eat?

Newsy (Oct. 23, 2014) — Conflicting studies published in the same week re-ignited the debate over whether we should be eating breakfast. Video provided by Newsy
Powered by NewsLook.com
Ebola Fears Keep Guinea Hospitals Empty

Ebola Fears Keep Guinea Hospitals Empty

AP (Oct. 23, 2014) — Fears of Ebola are keeping doctors and patients alike away from hospitals in the West African nation of Guinea. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Despite Rising Death Toll, Many Survive Ebola

Despite Rising Death Toll, Many Survive Ebola

AP (Oct. 23, 2014) — The family of a Dallas nurse infected with Ebola in the US says doctors can no longer detect the virus in her. Despite the mounting death toll in West Africa, there are survivors there too. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) — Is your child ready? Video provided by Working Mother
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins