Featured Research

from universities, journals, and other organizations

Effect Of Diabetes On Heart May Differ By Ethnicity, Study Finds

Date:
March 9, 2006
Source:
Wake Forest University Baptist Medical Center
Summary:
Diabetes strongly increases the risk of heart failure in all ethnic groups, but early effects of diabetes on the heart may differ depending on whether the subjects are white, African-American, Hispanic or Chinese.

Diabetes strongly increases the risk of heart failure in all ethnic groups, but early effects of diabetes on the heart may differ depending on whether the subjects are white, African-American, Hispanic or Chinese. These results emerged from the Multi-Ethnic Study of Atherosclerosis (MESA) when the investigators focused on heart mass -- the weight of the heart muscle as measured by MRI, according to Alain Bertoni, M.D., M.P.H., at Wake Forest University School of Medicine.

Related Articles


"People with diabetes are recognized as having an increased risk of heart failure," Bertoni said. "We sought to better understand why.

We were especially interested in the role atherosclerosis may play."

In a report in the March issue of Diabetes Care, the researchers compared people with diabetes or impaired fasting glucose (which means their blood sugar levels were too high) with those who had normal blood sugar levels.

The investigators particularly looked at the muscle mass of the left ventricle, the part of the heart that pumps the blood through the aorta and out into the circulatory system. They measured the left ventricle itself, not the blood in it.

They also measured the volume of the ventricle when filled with blood just before it pumps the blood out. A lower volume indicates less blood is able to enter the ventricle, and suggests increased heart stiffness, said Bertoni.

"Increased left ventricular muscle mass suggests the future possibility of developing heart failure," he said. "We also think that if you have a stiffer heart, that could be an early indication that you have a propensity for developing heart failure."

MESA measured "subclinical" atherosclerosis -- atherosclerosis that has yet to produce symptoms -- through CT scans measuring the amount of calcium in the coronary arteries and ultrasound measuring the wall thickness of the carotid artery in the neck. Both are indications of atherosclerosis.

"Every ethnic group seems to have a set of abnormalities related to diabetes. While we think those with diabetes from all ethnic groups are at increased risk for heart failure, perhaps there is a different mechanism in play in each of the ethnic groups," Bertoni said.

"We found evidence that in whites, African-Americans, and Hispanics with diabetes there was increased heart muscle mass over those without diabetes," he said. In whites, the increased left ventricular mass was completely explained by subclinical atherosclerosis and high blood pressure, he said. With partial blockage of the coronary arteries, some areas of the heart muscle are getting less blood flow and are weakened, which means the rest of the heart muscle has to bulk up, he said.

In African-Americans and Hispanics, the increased mass was not fully explained by these factors. Among Chinese participants no differences in mass were observed.

In contrast, lower volumes, suggestive of increased stiffness, were seen in whites, blacks, and Chinese participants with diabetes, but not Hispanics.

Bertoni stressed that none of the MESA participants actually had heart failure. "We did not see any significant difference in the function of the heart, the squeeze of the heart."

"Other studies have in fact suggested that the incidence of heart failure is similar between whites and African-Americans with diabetes, but somewhat lower among Hispanics and Asians with diabetes."

The MESA investigators intend to follow the participants at least until 2008, with some participants in a sub-study called MESA Air being followed at least until 2012. If the measurements do predict heart failure, "they would help us target preventive therapies," Bertoni said.

"Further investigation will be required to determine whether there are differences in the incidence of heart failure by ethnicity in this [group], and if so, whether the observed differences at baseline will be predictive of the future risk of heart failure," the researchers said in Diabetes Care.

Other investigators at Wake Forest include David C. Goff Jr., M.D., Ph.D., Ralph B. D'Agostino Jr., Ph.D., and W. Gregory Hundley, M.D. The team also includes Kiang Liu, Ph.D., of Northwestern University, Joao A. Lima, M.D., and Moyses Szklo, M.D., Dr.P.H., of Johns Hopkins University, Joseph F. Polak, M.D., M.P.H., of Tufts-New England Medical Center, Mohammed F. Saad, M.D., M.R.C.P., of Stony Brook University, Russell P. Tracy, Ph.D., of the University of Vermont and David S. Siscovick, M.D., M.P.H.


Story Source:

The above story is based on materials provided by Wake Forest University Baptist Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Wake Forest University Baptist Medical Center. "Effect Of Diabetes On Heart May Differ By Ethnicity, Study Finds." ScienceDaily. ScienceDaily, 9 March 2006. <www.sciencedaily.com/releases/2006/03/060309073442.htm>.
Wake Forest University Baptist Medical Center. (2006, March 9). Effect Of Diabetes On Heart May Differ By Ethnicity, Study Finds. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2006/03/060309073442.htm
Wake Forest University Baptist Medical Center. "Effect Of Diabetes On Heart May Differ By Ethnicity, Study Finds." ScienceDaily. www.sciencedaily.com/releases/2006/03/060309073442.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Christmas Kissing Good for Health

Christmas Kissing Good for Health

Reuters - Innovations Video Online (Dec. 22, 2014) Scientists in Amsterdam say couples transfer tens of millions of microbes when they kiss, encouraging healthy exposure to bacteria. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Brain-Dwelling Tapeworm Reveals Genetic Secrets

Brain-Dwelling Tapeworm Reveals Genetic Secrets

Reuters - Innovations Video Online (Dec. 22, 2014) Cambridge scientists have unravelled the genetic code of a rare tapeworm that lived inside a patient's brain for at least four year. Researchers hope it will present new opportunities to diagnose and treat this invasive parasite. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins