Featured Research

from universities, journals, and other organizations

Shape Matters To Macrophages: Phagocytosis Depends More On Particle Shape Than Size

Date:
March 23, 2006
Source:
University of California - Santa Barbara
Summary:
Researchers at UC Santa Barbara have made a surprising discovery: phagocytosis depends more on particle shape than size. The research, which has far-reaching implications for immunology, vaccine development and drug delivery, is published today online in the Proceedings of the National Academy of Sciences by Samir Mitragotri, a UCSB professor of chemical engineering, and a graduate student Julie A. Champion. The paper will be published in print on March 28.

Researchers at UC Santa Barbara have made a surprising discovery: phagocytosis depends more on particle shape than size. The research, which has far-reaching implications for immunology, vaccine development and drug delivery, is published today online in the Proceedings of the National Academy of Sciences by Samir Mitragotri, a UCSB professor of chemical engineering, and graduate student Julie A. Champion. The paper will be published in print on March 28.

Related Articles


Phagocytosis, a key part of the body's innate immune system, depends on macrophages -- the cell's clean-up crew. The macrophages find and frequently remove particles from the body. Prior to this discovery, it was believed that the ability of a macrophage to process a particle through phagocytosis was dependent solely on its size. Previous studies have been performed only with spherical samples because it was presumed that size was the main issue in phagocytosis, and because fabrication of non-spherical particles of controlled dimensions has been difficult.

The researchers used macrophages from alveolar (lung sac) rat tissue and developed polystyrene particles of various sizes and shapes as model targets. Mitragotri and Champion used scanning electron microscopy and time-lapse video microscopy to study the action of the macrophages when presented with targets of varying shapes.

Mitragotri says the next challenge is clear: learning how to engineer the shape of particles to enhance, delay or prevent phagocytosis. Such a discovery, for example could allow researchers to design drug carriers that can be purposefully retained by the body for a longer period of time, or could help researchers create vaccines that would be quickly removed to stimulate a rapid immune response.



Story Source:

The above story is based on materials provided by University of California - Santa Barbara. Note: Materials may be edited for content and length.


Cite This Page:

University of California - Santa Barbara. "Shape Matters To Macrophages: Phagocytosis Depends More On Particle Shape Than Size." ScienceDaily. ScienceDaily, 23 March 2006. <www.sciencedaily.com/releases/2006/03/060322183627.htm>.
University of California - Santa Barbara. (2006, March 23). Shape Matters To Macrophages: Phagocytosis Depends More On Particle Shape Than Size. ScienceDaily. Retrieved November 22, 2014 from www.sciencedaily.com/releases/2006/03/060322183627.htm
University of California - Santa Barbara. "Shape Matters To Macrophages: Phagocytosis Depends More On Particle Shape Than Size." ScienceDaily. www.sciencedaily.com/releases/2006/03/060322183627.htm (accessed November 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, November 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com
Raw: Paralyzed Marine Walks With Robotic Braces

Raw: Paralyzed Marine Walks With Robotic Braces

AP (Nov. 21, 2014) Marine Corps officials say a special operations officer left paralyzed by a sniper's bullet in Afghanistan walked using robotic leg braces in a ceremony to award him a Bronze Star. (Nov. 21) Video provided by AP
Powered by NewsLook.com
Milestone Birthdays Can Bring Existential Crisis, Study Says

Milestone Birthdays Can Bring Existential Crisis, Study Says

Newsy (Nov. 21, 2014) Researchers find that as people approach new decades in their lives they make bigger life decisions. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins