Featured Research

from universities, journals, and other organizations

Appetite-inducing Hormone Receptor Found Active In Breast Cancer

Date:
April 10, 2006
Source:
University of Cincinnati
Summary:
A hormone receptor with regulatory roles as diverse as food intake, fear response, and cardiovascular function may also be involved in breast cancer, according to University of Cincinnati (UC) researchers.

A hormone receptor with regulatory roles as diverse as food intake, fear response, and cardiovascular function may also be involved in breast cancer, according to UC researchers.

The UC research team, led by Hassane Amlal, PhD, and Sulaiman Sheriff, PhD, report their laboratory findings on the hormone, neuropeptide Y, and its receptor in the April edition of the journal Cancer Research.

Earlier studies have shown that neuropeptide Y’s receptor, known as Y1, is overproduced in human ovarian, prostate and breast cancers. This study, however, is the first to demonstrate that the Y1 receptor is actually working in breast cancer cells and can be “turned on” by excessive estrogen—a known cause of about 60 to 70 percent of breast cancers, they say.

“The high incidence and activity of the Y1 receptor in human breast tumor cells suggests that it may play an important role in breast cancer,” explains Dr. Sheriff, a UC research assistant professor in the department of surgery.

Pilot data suggests that about 40 percent of all breast cancer patients have increased levels of the Y1 receptor, he says.

“We knew this receptor was overproduced in breast cancer tissue,” adds Dr. Amlal, a research assistant professor in the department of internal medicine, “but now the real question is what does it do in breast cancer cells, and how can we use it as a target to fight cancer.”

The UC researchers were able to slow the growth of breast cancer cells with abnormally high levels of the Y1 receptor by treating them with neuropeptide Y hormone produced by chemical synthesis.

“This finding gives us a promising new investigational target in the fight against breast cancer,” the authors report. “If we can find a way to selectively activate the Y1 receptor, we can limit breast cancer growth in the body.”

Further studies of the Y1 receptor’s role, they explain, may ultimately lead to more targeted drug therapy for many breast cancer patients.

According to the American Cancer Society, more than 214,000 women and men will be diagnosed with breast cancer in 2006. About 19 percent will die from the disease.

This study was sponsored by UC and the National Institutes of Health. The research team also included Somia Faroqui, and Ambikaipakan Balasubramaniam, PhD.


Story Source:

The above story is based on materials provided by University of Cincinnati. Note: Materials may be edited for content and length.


Cite This Page:

University of Cincinnati. "Appetite-inducing Hormone Receptor Found Active In Breast Cancer." ScienceDaily. ScienceDaily, 10 April 2006. <www.sciencedaily.com/releases/2006/04/060410111450.htm>.
University of Cincinnati. (2006, April 10). Appetite-inducing Hormone Receptor Found Active In Breast Cancer. ScienceDaily. Retrieved September 23, 2014 from www.sciencedaily.com/releases/2006/04/060410111450.htm
University of Cincinnati. "Appetite-inducing Hormone Receptor Found Active In Breast Cancer." ScienceDaily. www.sciencedaily.com/releases/2006/04/060410111450.htm (accessed September 23, 2014).

Share This



More Health & Medicine News

Tuesday, September 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Liberia Pleads for Help to Fight Ebola

Liberia Pleads for Help to Fight Ebola

AP (Sep. 22, 2014) Liberia's finance minister is urging the international community to quickly follow through on pledges of cash to battle Ebola. Bodies are piling up in the capital Monrovia as the nation awaits more help. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Ebola Doctor Says Border Controls Critical

Ebola Doctor Says Border Controls Critical

AP (Sep. 22, 2014) A Florida doctor who helped fight the expanding Ebola outbreak in West Africa says the disease can be stopped, but only if nations quickly step up their response and make border control a priority. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Global Ebola Aid Increasing But Critics Say It's Late

Global Ebola Aid Increasing But Critics Say It's Late

Newsy (Sep. 21, 2014) More than 100 tons of medical supplies were sent to West Africa on Saturday, but aid workers say the global response is still sluggish. Video provided by Newsy
Powered by NewsLook.com
Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins