Featured Research

from universities, journals, and other organizations

Agent Protects Parkinson's Neurons From Rotenone Toxicity

Date:
April 19, 2006
Source:
University at Buffalo
Summary:
Researchers at the University at Buffalo affiliated with the New York State Center of Excellence in Bioinformatics and Life Sciences have identified a novel agent that can protect neurons involved in Parkinson's disease from being destroyed by the pesticide rotenone.

Researchers at the University at Buffalo affiliated with the New York State Center of Excellence in Bioinformatics and Life Sciences have identified a novel agent that can protect neurons involved in Parkinson's disease from being destroyed by the pesticide rotenone.

The agent, called L-AP4, activates a critical group of receptors called group III metabotropic glutamate receptors and may be a promising drug target. Currently there is no known cure for Parkinson's disease.

Long-term studies have shown that environmental toxins play a critical role in the development of Parkinson's disease, and it has been shown recently in research with rats that administering rotenone, a naturally occurring substance widely used as a pesticide, destroys dopamine-producing neurons and causes symptoms of Parkinson's disease in this animal model.

In the April 19 issue of The Journal of Neuroscience, UB researchers lead by Jian Feng, Ph.D., report that activation of group III metabotropic glutamate receptors reverses a cascade of events triggered by rotenone that destroys dopamine neurons.

Feng, UB associate professor of physiology and biophysics, and colleagues earlier demonstrated that microtubules, the intracellular highways for transporting dopamine and many vital cellular components, are critical for the survival of dopamine neurons, which are responsible for controlling body movement.

They showed that rotenone kills dopamine neurons by destroying microtubules, and that stabilizing microtubules greatly reduces the toxicity of rotenone.

In this new study, Feng's group has found that activation of group III metabotropic glutamate receptors by drugs such as L-AP4 triggers a chain of events that leads to microtubule stabilization. This cascade, called the MAP kinase pathway, activates several enzymes that regulate the stability of microtubules.

The primary symptoms of Parkinson's disease are tremors, slowness in movements, and impaired balance and coordination. At least 500,000 people are believed to suffer from Parkinson's disease in the United States, and about 50,000 new cases are reported annually, according to the National Institutes of Health. These figures are expected to increase as the population ages: The average age of onset is about 60. The disorder appears to be slightly more common in men than women.

Additional authors on the paper are Qian Jiang, Ph.D., postdoctoral associate, and Zhen Yan, Ph.D., associate professor, both in the UB Department of Physiology and Biophysics. Feng and Yan are members of the Neurodegenerative Disease Team with UB's New York State Center of Excellence in Bioinformatics and Life Sciences.

The research is funded by a grant to Feng from the National Institutes of Health.


Story Source:

The above story is based on materials provided by University at Buffalo. Note: Materials may be edited for content and length.


Cite This Page:

University at Buffalo. "Agent Protects Parkinson's Neurons From Rotenone Toxicity." ScienceDaily. ScienceDaily, 19 April 2006. <www.sciencedaily.com/releases/2006/04/060419082813.htm>.
University at Buffalo. (2006, April 19). Agent Protects Parkinson's Neurons From Rotenone Toxicity. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2006/04/060419082813.htm
University at Buffalo. "Agent Protects Parkinson's Neurons From Rotenone Toxicity." ScienceDaily. www.sciencedaily.com/releases/2006/04/060419082813.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Vaccine Trials to Start a in January

WHO: Ebola Vaccine Trials to Start a in January

AP (Oct. 21, 2014) Tens of thousands of doses of experimental Ebola vaccines could be available for "real-world" testing in West Africa as soon as January as long as they are deemed safe in soon to start trials, the World Health Organization said Tuesday. (Oct. 21) Video provided by AP
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins