Featured Research

from universities, journals, and other organizations

Inhibiting Cell Process May Give Cancer Drug A Boost

Date:
May 3, 2006
Source:
University of Illinois at Chicago
Summary:
A molecule that interferes with the internal scaffolding that shapes the cell may kill cancer cells, retard the growth of tumors and give a boost to a common chemotherapy drug, according to researchers from the University of Illinois at Chicago.

A molecule that interferes with the internal scaffolding that shapes the cell may kill cancer cells, retard the growth of tumors and give a boost to a common chemotherapy drug, according to findings appearing in the May 3 issue of the European Journal of Cancer.

Although tumor growth depends on the rapid cell division and mobility of cancer cells -- processes highly dependent on the cytoskeleton -- the cytoskeleton has not been a target in treating cancer, said Primal de Lanerolle, professor of physiology and biophysics at the University of Illinois at Chicago and principal author of the study.

The researchers found that ML-7, which inhibits an enzyme called myosin light chain kinase, which is important to the structure and dynamics of the cytoskeleton, induces cell suicide, or apoptosis, in cultured breast and prostate cancer cell lines. In addition, treatment with ML-7 in combination with etoposide, a chemotherapy drug used to treat solid tumors, enhanced the ability of etoposide to kill cancer cells.

In animal models, ML-7 retarded growth of breast cancer and prostate cancer tumors. The combination of ML-7 and etoposide reduced tumor growth by 88.5 percent for the breast cancer tumors and by 79.1 percent in the prostate cancer tumors compared to controls.

Like many chemotherapy drugs, etoposide can have adverse side effects.

"Reducing the dose of the drug without losing effectiveness would have important clinical benefits," said de Lanerolle. "ML-7 seemed to be tolerated very well, without any overt toxic side effects of its own."

The study suggests an entirely new target for cancer therapies, de Lanerolle said. "Our study supports the idea that the cytoskeleton is important in determining whether cells live or die, and that destabilizing the cytoskeleton may be a good way to induce apoptosis in cancer cells."

Researchers now must test ML-7 for toxicity and perform further preliminary animal experiments before human trials could be planned. Only a tiny fraction of promising candidate drugs enter clinical trials, and few of those are approved.

Lian-Zhi Gu, We-Yang Hu and Nenad Antic of UIC, Rajendra Mehta of the Illinois Institute of Technology Research Institute, and Jerrold Turner of the University of Chicago collaborated in the study. The study was supported in part by grants from the National Institutes of Health. Wen-Yang Hu is supported by the American Heart Association.


Story Source:

The above story is based on materials provided by University of Illinois at Chicago. Note: Materials may be edited for content and length.


Cite This Page:

University of Illinois at Chicago. "Inhibiting Cell Process May Give Cancer Drug A Boost." ScienceDaily. ScienceDaily, 3 May 2006. <www.sciencedaily.com/releases/2006/05/060503171807.htm>.
University of Illinois at Chicago. (2006, May 3). Inhibiting Cell Process May Give Cancer Drug A Boost. ScienceDaily. Retrieved August 1, 2014 from www.sciencedaily.com/releases/2006/05/060503171807.htm
University of Illinois at Chicago. "Inhibiting Cell Process May Give Cancer Drug A Boost." ScienceDaily. www.sciencedaily.com/releases/2006/05/060503171807.htm (accessed August 1, 2014).

Share This




More Health & Medicine News

Friday, August 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins