Featured Research

from universities, journals, and other organizations

Newly Discovered Dendritic Cells Generate Crucial Cells Of The Immune System

Date:
May 9, 2006
Source:
Walter and Eliza Hall Institute of Medical Research
Summary:
A new type of cell that generates crucial cells of the immune system has been discovered at The Walter and Eliza Hall Institute. With this new knowledge, medical researchers can begin to consider the development of customized immune therapies using this new cell to target specific infections such as HIV, malaria and influenza; certain cancers; and even autoimmune diseases.

A new type of cell that generates crucial cells of the immune system has been discovered at The Walter and Eliza Hall Institute. With this new knowledge, medical researchers can begin to consider the development of customized immune therapies using this new cell to target specific infections such as HIV, malaria and influenza; certain cancers; and even autoimmune diseases.

Related Articles


Dendritic cells (or "DC" ) are specialised white blood cells that patrol the body, searching for infections. DC seize and then internally break apart any infectiousorganisms that they find. These fragments are then presented on the waving branches or "dendrites" of the DC to activate the immune system's killer T cells. These activated T cells then eliminate the existing infection and resist any future attack by memorizing that infection.

DC also have an important educative role to play in preventing autoimmune diseases, such as type 1 diabetes and Multiple Sclerosis, where the body's immune system mistakes "self " for "foreign " and launches an attack. Since DC are central to many immune responses, they are potential targets for the development of new immune therapies.

Since their discovery in the US in 1975, it has been known that DC, like other white blood cells, develop from stem cells in the bone marrow. Exactly how that process happens has been a mystery -- until now. Using a mouse model, PhD student Shalin Naik, group leader Professor Ken Shortman and a team of colleagues at The Walter and Eliza Hall Institute have discovered the different " precursors " that produce DC. In doing so, they have also determined that the practical operations of DC are more specialized than previously believed. Rather than being generalized "police "within the body, it seems that DC are effectively organized as specialized squads that deal with specific problems -- just as a police force might have different departments to deal with armed robberies, homicides and fraud. These discoveries at WEHI have profoundly altered our understanding of this important aspect of the immune system.

The research received advance online publication on the Nature Immunology website on 7 May 2006.

The authors of the paper are Professor Ken Shortman, Professor Don Metcalf, Professor Ian Wicks, Dr Li Wu, Dr Meredith O'Keefe, Dr Annemarie van Nieuwenhuijze and Mr Shalin Naik.


Story Source:

The above story is based on materials provided by Walter and Eliza Hall Institute of Medical Research. Note: Materials may be edited for content and length.


Cite This Page:

Walter and Eliza Hall Institute of Medical Research. "Newly Discovered Dendritic Cells Generate Crucial Cells Of The Immune System." ScienceDaily. ScienceDaily, 9 May 2006. <www.sciencedaily.com/releases/2006/05/060508175917.htm>.
Walter and Eliza Hall Institute of Medical Research. (2006, May 9). Newly Discovered Dendritic Cells Generate Crucial Cells Of The Immune System. ScienceDaily. Retrieved February 27, 2015 from www.sciencedaily.com/releases/2006/05/060508175917.htm
Walter and Eliza Hall Institute of Medical Research. "Newly Discovered Dendritic Cells Generate Crucial Cells Of The Immune System." ScienceDaily. www.sciencedaily.com/releases/2006/05/060508175917.htm (accessed February 27, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, February 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could a $34 Smartphone Device Improve HIV Diagnosis in Africa?

Could a $34 Smartphone Device Improve HIV Diagnosis in Africa?

Reuters - Innovations Video Online (Feb. 27, 2015) A dongle that plugs into a Smartphone mimics a lab-based blood test for HIV and syphilis and can detect the diseases in 15 minutes, say researchers. Tara Cleary reports. Video provided by Reuters
Powered by NewsLook.com
Doctor Says Head Transplants Possible Within Two Years

Doctor Says Head Transplants Possible Within Two Years

Buzz60 (Feb. 27, 2015) An Italian doctor is saying he could stick someone&apos;s head onto someone else&apos;s body. Patrick Jones (@Patrick_E_Jones) reports. Video provided by Buzz60
Powered by NewsLook.com
How Your Dentist Could Help Screen You For Diabetes

How Your Dentist Could Help Screen You For Diabetes

Newsy (Feb. 27, 2015) A new study from researchers at New York University suggests dentists could soon use blood samples taken from patients&apos; mouths to test for diabetes. Video provided by Newsy
Powered by NewsLook.com
The Best Tips to Makeover Your Health

The Best Tips to Makeover Your Health

Buzz60 (Feb. 27, 2015) If you&apos;re looking to boost your health this season, there are a few quick and easy steps to prompt you for success. Krystin Goodwin (@Krystingoodwin) has the best tips to give your health a makeover this spring! Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins