Featured Research

from universities, journals, and other organizations

Blood Test Predicts Success Of Quitting Smoking Using The Nicotine Patch

Date:
May 19, 2006
Source:
University of Pennsylvania School of Medicine
Summary:
According to a study from the Abramson Cancer Center of the University of Pennsylvania and the University of Pennsylvania Transdisciplinary Tobacco Use Research Center, a blood test may enable doctors to predict which smokers using the nicotine patch are likely to experience the least amount of cravings and have the highest probability of success in quitting cigarettes.

A blood test may enable doctors to predict which smokers using the nicotine patch are likely to experience the least amount of cravings and have the highest probability of success in quitting cigarettes, according to the results of a study in the June issue of the Journal of Clinical Pharmacology and Therapeutics.

Related Articles


The blood test, which is a measure of the rate at which nicotine is metabolized, may eventually be performed non-invasively using saliva or urine samples. “The ultimate aim here is to distinguish smokers who are likely to benefit from a standard dose of nicotine patch from those who may need a higher dose patch or an alternative therapy in order to succeed in quitting,” said lead researcher for the study, Caryn Lerman, PhD, Associate Director for Cancer Control and Population Science at the Abramson Cancer Center of the University of Pennsylvania, and Director of the University of Pennsylvania Transdisciplinary Tobacco Use Research Center.

When nicotine is metabolized – or broken down in the body – it turns to cotinine. Cotinine is then metabolized to 3-hydroxycotinine (3-HC) by an enzyme in the liver. This study measured the ratio of these two breakdown products of nicotine among 480 smokers. A high ratio meant rapid metabolism of nicotine, which was associated with higher amounts of craving and greater difficulty in quitting cigarettes using the nicotine patch.

The smokers who participated in the study quit smoking and started using either the patch or the nicotine nasal spray for eight weeks. Measurements of carbon monoxide levels in exhaled air identified those who were not smoking at the eight-week and six-month intervals following the quit date. Study participants also provided information on level of cravings for cigarettes one week after their quit date.

“Using the rate of nicotine metabolism, we were able to predict the level of cravings and the efficacy of the nicotine patch,” said Lerman. “Similar results could not be obtained for the nicotine spray, most likely because the subjects were able to compensate for rapid metabolism of nicotine by using the spray more often.”

“If a prospective study replicates these results, we will be in a position to recommend this blood test to tailor the type and dose of nicotine replacement therapy for smokers who wish to quit,” Lerman said.

This study was funded by the National Cancer Institute, the National Institute on Drug Abuse, and the Pennsylvania State Tobacco Settlement. The Robert Wood Johnson Foundation has also supported the University of Pennsylvania’s Transdisciplinary Tobacco Use Research Center, which conducted this research.

The paper based on this study is scheduled for the June issue of the Journal of Clinical Pharmacology and Therapeutics. It has been posted on the web for subscribers.


Story Source:

The above story is based on materials provided by University of Pennsylvania School of Medicine. Note: Materials may be edited for content and length.


Cite This Page:

University of Pennsylvania School of Medicine. "Blood Test Predicts Success Of Quitting Smoking Using The Nicotine Patch." ScienceDaily. ScienceDaily, 19 May 2006. <www.sciencedaily.com/releases/2006/05/060519124411.htm>.
University of Pennsylvania School of Medicine. (2006, May 19). Blood Test Predicts Success Of Quitting Smoking Using The Nicotine Patch. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2006/05/060519124411.htm
University of Pennsylvania School of Medicine. "Blood Test Predicts Success Of Quitting Smoking Using The Nicotine Patch." ScienceDaily. www.sciencedaily.com/releases/2006/05/060519124411.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Mind & Brain News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Buzz60 (Dec. 19, 2014) A double-amputee makes history by becoming the first person to wear and operate two prosthetic arms using only his mind. Jen Markham has the story. Video provided by Buzz60
Powered by NewsLook.com
Prenatal Exposure To Pollution Might Increase Autism Risk

Prenatal Exposure To Pollution Might Increase Autism Risk

Newsy (Dec. 18, 2014) Harvard researchers found children whose mothers were exposed to high pollution levels in the third trimester were twice as likely to develop autism. Video provided by Newsy
Powered by NewsLook.com
Yoga Could Be As Beneficial For The Heart As Walking, Biking

Yoga Could Be As Beneficial For The Heart As Walking, Biking

Newsy (Dec. 17, 2014) Yoga can help your weight, blood pressure, cholesterol and heart just as much as biking and walking does, a new study suggests. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins