Featured Research

from universities, journals, and other organizations

New Kind Of Mutation Could Explain Numerous Phenotypic Variations In Various Species

Date:
June 5, 2006
Source:
University of Liege
Summary:
Thanks to a recent study on the genetic factors that promote muscular hypertrophy among Texel sheep, Prof. Michel Georges' team at the University of LiĬge has discovered a new kind of mutation that could be at the origin of many phenotypes in various species, among which humans, including genetic predispositions to certain hereditary diseases. This discovery is of significant interest to the international scientific community. The results are published in this week's edition of the American journal Nature Genetics.

Thanks to a recent study on the genetic factors that promote muscular hypertrophy among Texel sheep, Prof. Michel Georges' team at the University of Lige has discovered a new kind of mutation that could be at the origin of many phenotypes in various species, among which humans, including genetic predispositions to certain hereditary diseases. This discovery is of significant interest to the international scientific community. The results are published in this week's edition of the American journal Nature Genetics.

The authors describe the discovery of a novel class of mutations that disrupt the function of a gene and thereby cause a specific phenotype. The mutation created the appearance of an "illegitimate" microRNA (miRNA) recognition site in a gene that did not have it in its normal form.

In this study, the gene concerned is the myostatin. This gene is expressed in the skeletal muscle and the function of the derived protein is to inhibit muscular growth. The mutation discovered among sheep exposed a recognition site for two miRNAs that are highly expressed in the muscle. In "mutant" animals, these miRNAs will consequently target the myostatin gene and block its translation. The result is that the absence of myostatin provokes a muscular hypertrophy among Texel sheep.

A mechanism observed in other species as well

However, Michel Georges' team investigated further. Pursuing the study using bioinformatic approaches, the team identified polymorphisms (common mutations) among humans and mice that are likely to act in the same way as they do in the Texel breed. It appears, therefore, that this new kind of mutation, discovered while studying sheep, could contribute significantly to the phenotypic variation observed in many species – among which humans – including the hereditary predisposition to various diseases.

Researchers at ULg have thus produced a database available online that compiles all these mutations (the Patrocles database: http://www.patrocles.org). It will assist researchers around the world in discovering similar phenomena for other phenotypes including hereditary diseases.


Story Source:

The above story is based on materials provided by University of Liege. Note: Materials may be edited for content and length.


Cite This Page:

University of Liege. "New Kind Of Mutation Could Explain Numerous Phenotypic Variations In Various Species." ScienceDaily. ScienceDaily, 5 June 2006. <www.sciencedaily.com/releases/2006/06/060605115947.htm>.
University of Liege. (2006, June 5). New Kind Of Mutation Could Explain Numerous Phenotypic Variations In Various Species. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2006/06/060605115947.htm
University of Liege. "New Kind Of Mutation Could Explain Numerous Phenotypic Variations In Various Species." ScienceDaily. www.sciencedaily.com/releases/2006/06/060605115947.htm (accessed July 23, 2014).

Share This




More Fossils & Ruins News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Neil Armstrong's Post-Apollo 11 Life

Neil Armstrong's Post-Apollo 11 Life

Newsy (July 19, 2014) Neil Armstrong gained international fame after becoming the first man to walk on the moon in 1969. But what was his life like after the historic trip? Video provided by Newsy
Powered by NewsLook.com
A Centuries' Old British Tradition Is Far from a Swan Song

A Centuries' Old British Tradition Is Far from a Swan Song

AFP (July 19, 2014) As if it weren't enough that the Queen is the Sovereign of the UK and 15 other Commonwealth realms, she is also the owner of all Britain's unmarked swans. Duration: 02:18 Video provided by AFP
Powered by NewsLook.com
Tooth Plaque Provides Insight Into Diets Of Ancient People

Tooth Plaque Provides Insight Into Diets Of Ancient People

Newsy (July 19, 2014) Research on plaque from ancient teeth shows that our prehistoric ancestor's had a detailed understanding of plants long before developing agriculture. Video provided by Newsy
Powered by NewsLook.com
45 Years Later, Buzz Aldrin on Walking on Moon

45 Years Later, Buzz Aldrin on Walking on Moon

AP (July 18, 2014) Forty-five years ago Sunday, Apollo 11's Neil Armstrong and Buzz Aldrin became the first humans to set foot on the moon. Speaking at the Intrepid Sea, Air & Space Museum, Aldrin described what he was thinking right before the historic walk. (July 18) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins