Featured Research

from universities, journals, and other organizations

New Kind Of Mutation Could Explain Numerous Phenotypic Variations In Various Species

Date:
June 5, 2006
Source:
University of Liege
Summary:
Thanks to a recent study on the genetic factors that promote muscular hypertrophy among Texel sheep, Prof. Michel Georges' team at the University of LiĬge has discovered a new kind of mutation that could be at the origin of many phenotypes in various species, among which humans, including genetic predispositions to certain hereditary diseases. This discovery is of significant interest to the international scientific community. The results are published in this week's edition of the American journal Nature Genetics.

Thanks to a recent study on the genetic factors that promote muscular hypertrophy among Texel sheep, Prof. Michel Georges' team at the University of Lige has discovered a new kind of mutation that could be at the origin of many phenotypes in various species, among which humans, including genetic predispositions to certain hereditary diseases. This discovery is of significant interest to the international scientific community. The results are published in this week's edition of the American journal Nature Genetics.

Related Articles


The authors describe the discovery of a novel class of mutations that disrupt the function of a gene and thereby cause a specific phenotype. The mutation created the appearance of an "illegitimate" microRNA (miRNA) recognition site in a gene that did not have it in its normal form.

In this study, the gene concerned is the myostatin. This gene is expressed in the skeletal muscle and the function of the derived protein is to inhibit muscular growth. The mutation discovered among sheep exposed a recognition site for two miRNAs that are highly expressed in the muscle. In "mutant" animals, these miRNAs will consequently target the myostatin gene and block its translation. The result is that the absence of myostatin provokes a muscular hypertrophy among Texel sheep.

A mechanism observed in other species as well

However, Michel Georges' team investigated further. Pursuing the study using bioinformatic approaches, the team identified polymorphisms (common mutations) among humans and mice that are likely to act in the same way as they do in the Texel breed. It appears, therefore, that this new kind of mutation, discovered while studying sheep, could contribute significantly to the phenotypic variation observed in many species – among which humans – including the hereditary predisposition to various diseases.

Researchers at ULg have thus produced a database available online that compiles all these mutations (the Patrocles database: http://www.patrocles.org). It will assist researchers around the world in discovering similar phenomena for other phenotypes including hereditary diseases.


Story Source:

The above story is based on materials provided by University of Liege. Note: Materials may be edited for content and length.


Cite This Page:

University of Liege. "New Kind Of Mutation Could Explain Numerous Phenotypic Variations In Various Species." ScienceDaily. ScienceDaily, 5 June 2006. <www.sciencedaily.com/releases/2006/06/060605115947.htm>.
University of Liege. (2006, June 5). New Kind Of Mutation Could Explain Numerous Phenotypic Variations In Various Species. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2006/06/060605115947.htm
University of Liege. "New Kind Of Mutation Could Explain Numerous Phenotypic Variations In Various Species." ScienceDaily. www.sciencedaily.com/releases/2006/06/060605115947.htm (accessed October 24, 2014).

Share This



More Fossils & Ruins News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deep Sea 'mushroom' Could Be Early Branch on Tree of Life

Deep Sea 'mushroom' Could Be Early Branch on Tree of Life

Reuters - Innovations Video Online (Oct. 24, 2014) Miniature deep sea animals discovered off the Australian coast almost three decades ago are puzzling scientists, who say the organisms have proved impossible to categorise. Academics at the Natural History of Denmark have appealed to the world scientific community for help, saying that further information on Dendrogramma enigmatica and Dendrogramma discoides could answer key evolutionary questions. Jim Drury has more. Video provided by Reuters
Powered by NewsLook.com
Fossil Treasures at Risk in Morocco Desert Town

Fossil Treasures at Risk in Morocco Desert Town

AFP (Oct. 23, 2014) Hundreds of archeological jewels in and around the town of 30,000 people prompt geologists and archeologists to call the Erfoud area "the largest open air fossil museum in the world". Duration: 02:17 Video provided by AFP
Powered by NewsLook.com
Oldest Bone Ever Sequenced Shows Human/Neanderthal Mating

Oldest Bone Ever Sequenced Shows Human/Neanderthal Mating

Newsy (Oct. 23, 2014) A 45,000-year-old thighbone is showing when humans and neanderthals may have first interbred and revealing details about our origins. Video provided by Newsy
Powered by NewsLook.com
Weird-Looking Dinosaur Solves 50-Year-Old Mystery

Weird-Looking Dinosaur Solves 50-Year-Old Mystery

Newsy (Oct. 23, 2014) You've probably seen some weird-looking dinosaurs, but have you ever seen one this weird? It's worth a look. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins