Featured Research

from universities, journals, and other organizations

Mosquito Immune System: Same Immune Factors Used To Fight Malaria Parasite And Infectious Pathogens

Date:
June 12, 2006
Source:
Johns Hopkins University Bloomberg School of Public Health
Summary:
Mosquitoes employ the same immune factors to fight off bacterial pathogens as they do to kill malaria-causing Plasmodium parasites, according to a study by researchers at the Johns Hopkins Bloomberg School of Public Health. They identified several genes that encode proteins of the mosquito's immune system. According to the authors, the findings add to the understanding of mosquito immunity, and could contribute towards the development of malaria-control strategies based on blocking the parasite in the mosquito.

Mosquitoes employ the same immune factors to fight off bacterial pathogens as they do to kill malaria-causing Plasmodium parasites, according to a study by researchers at the Johns Hopkins Bloomberg School of Public Health. The study identified several genes that encode proteins of the mosquito's immune system.

Related Articles


All of the immune genes that were involved in limiting infection by the malaria parasites were also important for the resistance to bacterial infection. However, several immune genes that were essential for resistance to bacterial infection did not affect Plasmodium infection. According to the authors, the findings add to the understanding of mosquito immunity, and could contribute towards the development of malaria-control strategies based on blocking the parasite in the mosquito. The study is published in the June 8, 2006, edition of PloS Pathogens.

"Mosquitoes that transmit malaria can kill large portions of Plasmodium parasites, and some mosquito strains are totally resistant to Plasmodium. However, our observations suggest that mosquitoes have not evolved a highly-specific defense against malaria parasites. Instead, they employ factors of their antimicrobial defense system to combat the Plasmodium parasite," said George Dimopoulos, Ph.D., senior author of the study and assistant professor with the Bloomberg School's Malaria Research Institute. "The degree of mosquito susceptibility to Plasmodium, and thereby its capacity to transmit malaria, may therefore partly depend on the mosquito's microbial exposure, which can differ greatly between different geographic sites. Potentially, we could boost the mosquito's capacity to fight the malaria parasite by exposing it to certain microbes or compounds that resemble the microbe molecules responsible for immune activation."

In this study, the investigators also analyzed the immune responses of Anopheles gambiae mosquitoes to infection with different Plasmodium parasite species, one that causes malaria in humans and another that only infects rodents. The study revealed that mosquitoes mostly employ the same immune factors in defending against the two different Plasmodium species. Only a few immune genes were more important in the defense against either one of the two species.

"The mosquito's immune system appears to employ a variety of antimicrobial defense factors (genes) against the malaria parasite, and can therefore significantly limit infection. The parasite, on the other hand, is capable of evading these defenses to a degree that allows its transmission by the mosquito. Now we have to figure out how to make the mosquito's immune system more effective in killing malaria parasites at multiple stages that would render the development of evasive mechanisms impossible for the parasite," said Dimopoulos.


Story Source:

The above story is based on materials provided by Johns Hopkins University Bloomberg School of Public Health. Note: Materials may be edited for content and length.


Cite This Page:

Johns Hopkins University Bloomberg School of Public Health. "Mosquito Immune System: Same Immune Factors Used To Fight Malaria Parasite And Infectious Pathogens." ScienceDaily. ScienceDaily, 12 June 2006. <www.sciencedaily.com/releases/2006/06/060611101616.htm>.
Johns Hopkins University Bloomberg School of Public Health. (2006, June 12). Mosquito Immune System: Same Immune Factors Used To Fight Malaria Parasite And Infectious Pathogens. ScienceDaily. Retrieved March 29, 2015 from www.sciencedaily.com/releases/2006/06/060611101616.htm
Johns Hopkins University Bloomberg School of Public Health. "Mosquito Immune System: Same Immune Factors Used To Fight Malaria Parasite And Infectious Pathogens." ScienceDaily. www.sciencedaily.com/releases/2006/06/060611101616.htm (accessed March 29, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, March 29, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) — The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins