Featured Research

from universities, journals, and other organizations

Research Identifies Protein In Mice That Regulates Bone Formation

Date:
June 23, 2006
Source:
Harvard School of Public Health
Summary:
Eliminating a protein, Schnurri-3 (Shn3), in mice led to profound increases in bone mass throughout their skeletal system. The results may have implications for the treatment of osteoporosis.

Osteoporosis, a disease characterized by a decrease in bone mass and density and which makes people more susceptible to bone fractures and deformities, afflicts some 10 million Americans over the age of 50. Researchers at the Harvard School of Public Health (HSPH) have discovered that eliminating a protein, Schnurri-3 (Shn3), in mice led to profound increases in bone mass throughout their skeletal system. The results may have implications for the treatment of osteoporosis. The study was published in the May 26 edition of Science.

Osteoporosis has serious health consequences. One-fifth of patients with osteoporosis who fracture their hips will die within a year. As the baby boomer generation gets older, it is predicted that the number of hip fractures may triple by 2020 unless better prevention and treatment for the disease is improved.

The researchers, led by Dallas Jones, a research associate in the Department of Immunology and Infectious Diseases, Marc Wein, an MD, PhD student, and senior author Laurie Glimcher, Professor of Immunology, observed that augmented osteoblast activity, rather than impaired osteoclast activity, was responsible for the elevated bone mass. Osteoblasts are cells that form new bone. Jones, Wein and their colleagues found that Shn3 formed a complex with a protein known as WWP1; together, the pair degrades Runx2, a transcription factor that is the master regulator of osteoblast differentiation, which activates key bone formation genes. By removing Shn3 or WWP1, Runx2 doesnt degrade, which leads to increased bone mass.

The authors believe that targeting Shn3 and WWP1 for drug discovery is an exciting prospect. Glimcher's lab has forged a collaboration with Brandeis University biochemist Greg Petsko to find compounds that inhibit the two proteins, which could lead to new and better treatments for osteoporosis. Though the biggest hurdles of drug discovery lie in the distant future, said Petsko, "as early stage targets go, this looks promising. It just smells like a good target."

The study was supported by NIH grants, a grant from the Peabody Foundation, post-doctoral fellowships from the Arthritis Foundation and the Irvington Institute, and by the Medical Scientist Training Program at Harvard Medical School.


Story Source:

The above story is based on materials provided by Harvard School of Public Health. Note: Materials may be edited for content and length.


Cite This Page:

Harvard School of Public Health. "Research Identifies Protein In Mice That Regulates Bone Formation." ScienceDaily. ScienceDaily, 23 June 2006. <www.sciencedaily.com/releases/2006/06/060623001349.htm>.
Harvard School of Public Health. (2006, June 23). Research Identifies Protein In Mice That Regulates Bone Formation. ScienceDaily. Retrieved April 24, 2014 from www.sciencedaily.com/releases/2006/06/060623001349.htm
Harvard School of Public Health. "Research Identifies Protein In Mice That Regulates Bone Formation." ScienceDaily. www.sciencedaily.com/releases/2006/06/060623001349.htm (accessed April 24, 2014).

Share This



More Health & Medicine News

Thursday, April 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Big Pharma Braces for M&A Wave

Big Pharma Braces for M&A Wave

Reuters - Business Video Online (Apr. 22, 2014) Big pharma on the move as Novartis boss, Joe Jimenez, tells Reuters about plans to transform his company via an asset exchange with GSK, and Astra Zeneca shares surge on speculation that Pfizer is looking for a takeover. Joanna Partridge reports. Video provided by Reuters
Powered by NewsLook.com
Study Says Most Crime Not Linked To Mental Illness

Study Says Most Crime Not Linked To Mental Illness

Newsy (Apr. 22, 2014) A new study finds most crimes committed by people with mental illness are not caused by symptoms of their illness or disorder. Video provided by Newsy
Powered by NewsLook.com
Hagel Gets Preview of New High-Tech Projects

Hagel Gets Preview of New High-Tech Projects

AP (Apr. 22, 2014) Defense Secretary Chuck Hagel is given hands-on demonstrations Tuesday of some of the newest research from DARPA _ the military's Defense Advanced Research Projects Agency program. (April 22) Video provided by AP
Powered by NewsLook.com
How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins