Featured Research

from universities, journals, and other organizations

Researchers Aim To Cut Future Need For Liver Transplants

Date:
July 7, 2006
Source:
University of Edinburgh
Summary:
University of Edinburgh scientists have identified primitive liver cells -- possibly dormant from the earliest developmental stage of a human being -- which have the potential to mature into different cells types and help repair a failing liver.

University of Edinburgh scientists have identified primitive liver cells –possibly dormant from the earliest developmental stage of a human being – which have the potential to mature into different cells types and help repair a failing liver. Their newly-published findings could pave the way for alternative treatments using cell replacements instead of organ transplants for those with liver failure.

Related Articles


A functioning liver is essential for human survival with liver failure ultimately resulting in death, and liver transplantation is presently the only treatment for acute and chronic liver failure. However, the supply of donor livers is insufficient to meet demand, and in the United Kingdom, 20% of patients waiting for a liver transplant will die from liver failure before a suitable donated organ becomes available.

Head of the group Dr James Ross said: "Potentially, cell replacement therapies could provide alternative treatments that would avoid difficulties associated with obtaining sufficient donor organ transplantation. We have now identified primitive cells with the potential to mature into different cell types within and out with the liver. It is possible that these cells lie dormant in the adult liver and may be the source of repair cells that are activated by severe liver injury."

"The liver is often able to repair and heal itself following injury or damage and this occurs in one of three ways. Firstly, mature liver cells have a well recognised and extensive capacity to divide in response to injury. Secondly, in response to massive loss of functioning liver tissue, a population of primitive liver stem cells may be stimulated to proliferate and develop into mature liver cells. The third mechanism of liver repair involves circulating stem cells originating from other sources, such as the bone marrow, and it is possible that these cells may be recruited into the liver and form new liver cells."

The research team is based in the Department of Surgery and in the Tissue Injury & Repair Group, Centre for Regenerative Medicine, at the University of Edinburgh.

The findings are published in the current edition of The American Journal of Physiology- Gastrointestinal and Liver Physiology.


Story Source:

The above story is based on materials provided by University of Edinburgh. Note: Materials may be edited for content and length.


Cite This Page:

University of Edinburgh. "Researchers Aim To Cut Future Need For Liver Transplants." ScienceDaily. ScienceDaily, 7 July 2006. <www.sciencedaily.com/releases/2006/07/060706175049.htm>.
University of Edinburgh. (2006, July 7). Researchers Aim To Cut Future Need For Liver Transplants. ScienceDaily. Retrieved November 1, 2014 from www.sciencedaily.com/releases/2006/07/060706175049.htm
University of Edinburgh. "Researchers Aim To Cut Future Need For Liver Transplants." ScienceDaily. www.sciencedaily.com/releases/2006/07/060706175049.htm (accessed November 1, 2014).

Share This



More Health & Medicine News

Saturday, November 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Melafind: Spotting Melanoma Without a Biopsy

Melafind: Spotting Melanoma Without a Biopsy

Ivanhoe (Oct. 31, 2014) The MelaFind device is a pain-free way to check suspicious moles for melanoma, without the need for a biopsy. Video provided by Ivanhoe
Powered by NewsLook.com
Battling Multiple Myeloma

Battling Multiple Myeloma

Ivanhoe (Oct. 31, 2014) The answer isn’t always found in new drugs – repurposing an ‘old’ drug that could mean better multiple myeloma treatment, and hope. Video provided by Ivanhoe
Powered by NewsLook.com
Chronic Inflammation and Prostate Cancer

Chronic Inflammation and Prostate Cancer

Ivanhoe (Oct. 31, 2014) New information that is linking chronic inflammation in the prostate and prostate cancer, which may help doctors and patients prevent cancer in the future. Video provided by Ivanhoe
Powered by NewsLook.com
Sickle Cell: Stopping Kids’ Silent Strokes

Sickle Cell: Stopping Kids’ Silent Strokes

Ivanhoe (Oct. 31, 2014) Blood transfusions are proving crucial to young sickle cell patients by helping prevent strokes, even when there is no outward sign of brain injury. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins