Featured Research

from universities, journals, and other organizations

Researchers Aim To Cut Future Need For Liver Transplants

Date:
July 7, 2006
Source:
University of Edinburgh
Summary:
University of Edinburgh scientists have identified primitive liver cells -- possibly dormant from the earliest developmental stage of a human being -- which have the potential to mature into different cells types and help repair a failing liver.

University of Edinburgh scientists have identified primitive liver cells –possibly dormant from the earliest developmental stage of a human being – which have the potential to mature into different cells types and help repair a failing liver. Their newly-published findings could pave the way for alternative treatments using cell replacements instead of organ transplants for those with liver failure.

A functioning liver is essential for human survival with liver failure ultimately resulting in death, and liver transplantation is presently the only treatment for acute and chronic liver failure. However, the supply of donor livers is insufficient to meet demand, and in the United Kingdom, 20% of patients waiting for a liver transplant will die from liver failure before a suitable donated organ becomes available.

Head of the group Dr James Ross said: "Potentially, cell replacement therapies could provide alternative treatments that would avoid difficulties associated with obtaining sufficient donor organ transplantation. We have now identified primitive cells with the potential to mature into different cell types within and out with the liver. It is possible that these cells lie dormant in the adult liver and may be the source of repair cells that are activated by severe liver injury."

"The liver is often able to repair and heal itself following injury or damage and this occurs in one of three ways. Firstly, mature liver cells have a well recognised and extensive capacity to divide in response to injury. Secondly, in response to massive loss of functioning liver tissue, a population of primitive liver stem cells may be stimulated to proliferate and develop into mature liver cells. The third mechanism of liver repair involves circulating stem cells originating from other sources, such as the bone marrow, and it is possible that these cells may be recruited into the liver and form new liver cells."

The research team is based in the Department of Surgery and in the Tissue Injury & Repair Group, Centre for Regenerative Medicine, at the University of Edinburgh.

The findings are published in the current edition of The American Journal of Physiology- Gastrointestinal and Liver Physiology.


Story Source:

The above story is based on materials provided by University of Edinburgh. Note: Materials may be edited for content and length.


Cite This Page:

University of Edinburgh. "Researchers Aim To Cut Future Need For Liver Transplants." ScienceDaily. ScienceDaily, 7 July 2006. <www.sciencedaily.com/releases/2006/07/060706175049.htm>.
University of Edinburgh. (2006, July 7). Researchers Aim To Cut Future Need For Liver Transplants. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2006/07/060706175049.htm
University of Edinburgh. "Researchers Aim To Cut Future Need For Liver Transplants." ScienceDaily. www.sciencedaily.com/releases/2006/07/060706175049.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Newsy (July 23, 2014) An 8-year-old boy helped his younger brother, who has a rare genetic condition that's confined him to a wheelchair, finish a triathlon. Video provided by Newsy
Powered by NewsLook.com
Thousands Who Can't Afford Medical Care Flock to Free US Clinic

Thousands Who Can't Afford Medical Care Flock to Free US Clinic

AFP (July 23, 2014) America may be the world’s richest country, but in terms of healthcare, the World Health Organisation ranks it 37th. Thousands turned out for a free clinic run by "Remote Area Medical" with a visit from the Governor of Virginia. Duration: 2:40 Video provided by AFP
Powered by NewsLook.com
Stone Fruit Listeria Scare Causes Sweeping Recall

Stone Fruit Listeria Scare Causes Sweeping Recall

Newsy (July 22, 2014) The Wawona Packing Company has issued a voluntary recall on the stone fruit it distributes due to a possible Listeria outbreak. Video provided by Newsy
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins