Featured Research

from universities, journals, and other organizations

Core Needle Biopsy Gives An Accurate Picture Of Gene Expression In Whole Tumour

Date:
August 18, 2006
Source:
BioMed Central
Summary:
The gene expression profile detected in the core needle biopsy of a breast tumour is representative of gene expression in the whole tumour. A study published today in the open access journal Breast Cancer Research confirms the reliability of core needle biopsy as a tool in breast cancer diagnosis and prognosis.

The gene expression profile detected in the core needle biopsy of a breast tumour is representative of gene expression in the whole tumour. A study published today in the open access journal Breast Cancer Research confirms the reliability of core needle biopsy as a tool in breast cancer diagnosis and prognosis. The study also shows that the gene expression profile of a core needle biopsy might be more accurate than the profile of a surgical sample taken from the same tumour, after the biopsy was carried out. According to the study results, the biopsy procedure seems to trigger the expression of genes involved in wound healing as well as tumour invasion and metastasis, thus modifying the gene expression profile of subsequent surgical samples.

Rosanna Zanetti-Dällenbach from the Women's University Hospital in Basel, Switzerland and colleagues from Stiftung Tumorbank, OncoScore AG and University Hospital in Basel, analysed the gene expression profile of core needle biopsies taken from 22 women diagnosed with breast cancer. For each woman, they compared the biopsy expression profile with the expression profile of a surgical sample taken from the tumour subsequently to the core needle biopsy. Zanetti-Dällenbach et al. quantified the expression of 60 genes known to be involved in breast tumour development using a technique called reverse polymerase chain reaction (PCR). Zanetti-Dällenbach et al. also analysed the gene expression profiles of surgical samples taken from the breast tumours of 317 patients who did not undergo a core needle biopsy.

The results of Zanetti-Dällenbach et al.'s study show that the gene expression levels of the core biopsy and the surgical sample are identical for most women. But the authors find that the expression of four specific genes is significantly increased in the surgical samples compared to the core needle biopsies. In the group of women who did not get a core needle biopsy, however, the expression of these four genes is not increased. These four genes are involved in inflammation and wound repair as well as tumour invasion and metastasis. The authors conclude that their expression must therefore be modified by the core needle biopsy procedure itself. They warn that care should be taken when interpreting the gene expression profile of a surgical sample carried out following a core biopsy. Although the tumor's aggressiveness has not changed, the modified profile in surgical samples obtained after core needle biopsy might influence data interpretation with respect to prediction of risk assessment and treatment response. The core needle biopsy sample may give a cleaner, more accurate and more representative profile of the levels of gene expression in the tumour.

Article: Comparison of gene expression profiles in core biopsies and corresponding surgical breast cancer samples Authors: Rosanna Zanetti-Dallenbach, Vincent Vuaroqueaux, Edward Wight, Martin Labuhn, Gad Singer, Patrick Urban, Urs Eppenberger, Wolfgang Holzgreve and Serenella Eppenberger-Castori

Breast Cancer Research, 2006 (in press) http://breast-cancer-research.com/


Story Source:

The above story is based on materials provided by BioMed Central. Note: Materials may be edited for content and length.


Cite This Page:

BioMed Central. "Core Needle Biopsy Gives An Accurate Picture Of Gene Expression In Whole Tumour." ScienceDaily. ScienceDaily, 18 August 2006. <www.sciencedaily.com/releases/2006/08/060818015803.htm>.
BioMed Central. (2006, August 18). Core Needle Biopsy Gives An Accurate Picture Of Gene Expression In Whole Tumour. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2006/08/060818015803.htm
BioMed Central. "Core Needle Biopsy Gives An Accurate Picture Of Gene Expression In Whole Tumour." ScienceDaily. www.sciencedaily.com/releases/2006/08/060818015803.htm (accessed October 22, 2014).

Share This



More Health & Medicine News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) — The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Vaccine Trials to Start a in January

WHO: Ebola Vaccine Trials to Start a in January

AP (Oct. 21, 2014) — Tens of thousands of doses of experimental Ebola vaccines could be available for "real-world" testing in West Africa as soon as January as long as they are deemed safe in soon to start trials, the World Health Organization said Tuesday. (Oct. 21) Video provided by AP
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) — A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) — The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins