Featured Research

from universities, journals, and other organizations

Knee Bone Marrow Lesions May Be Hereditary

Date:
September 8, 2006
Source:
BioMed Central
Summary:
Bone marrow lesions in the knee, a cause of pain in patients with knee osteoarthritis, may be hereditary. A study published today in the journal Arthritis Research & Therapy reveals that there is a significant genetic component to the occurrence and severity of bone marrow lesions in the tibia and femur. The study also shows that bone marrow lesions are more common in men and increase with age and weight.

Bone marrow lesions in the knee, a cause of pain in patients with knee osteoarthritis, may be hereditary. A study published today in the journal Arthritis Research & Therapy reveals that there is a significant genetic component to the occurrence and severity of bone marrow lesions in the tibia and femur. The study also shows that bone marrow lesions are more common in men and increase with age and weight.

Related Articles


Guangju Zhai, from St Thomas' Hospital, London, UK and colleagues from institutions in Australia studied 115 siblings from 48 families with a history of osteoarthritis. Zhai et al. used magnetic resonance imaging (MRI) to assess bone marrow lesions in the subjects. The authors then calculated the heritability estimates - or the extent to which they are hereditary - for bone marrow lesions in lateral and medial tibia and femur.

The results of Zhai et al.'s study show that the heritability estimate was 99% for the prevalence of bone marrow lesions in both lateral and medial compartments of the bones. The heritability estimates for the severity of bone marrow lesions are 53% for lateral bones and 65% for medial bones, after adjustment for age, sex, height, weight, muscle strength, knee pain and knee alignment.

The authors conclude that further studies to identify the gene(s) responsible for bone marrow lesions may help in the prevention and management of knee pain in osteoarthritis, the most common form of arthritis.

Article: Familial, structural, and environmental correlates of MRI-defined bone marrow lesions: A Sibpair Study
Guangju Zhai, James Stankovich, Flavia Cicuttini, Changhai Ding and Graeme Jones
Arthritis Research & Therapy 2006, (in press)


Story Source:

The above story is based on materials provided by BioMed Central. Note: Materials may be edited for content and length.


Cite This Page:

BioMed Central. "Knee Bone Marrow Lesions May Be Hereditary." ScienceDaily. ScienceDaily, 8 September 2006. <www.sciencedaily.com/releases/2006/08/060828074812.htm>.
BioMed Central. (2006, September 8). Knee Bone Marrow Lesions May Be Hereditary. ScienceDaily. Retrieved November 24, 2014 from www.sciencedaily.com/releases/2006/08/060828074812.htm
BioMed Central. "Knee Bone Marrow Lesions May Be Hereditary." ScienceDaily. www.sciencedaily.com/releases/2006/08/060828074812.htm (accessed November 24, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, November 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com
Winter Can Cause Depression — Here's How To Combat It

Winter Can Cause Depression — Here's How To Combat It

Newsy (Nov. 23, 2014) Millions of American suffer from seasonal depression every year. It can lead to adverse health effects, but there are ways to ease symptoms. Video provided by Newsy
Powered by NewsLook.com
Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

AFP (Nov. 23, 2014) The arable district of Kenema in Sierra Leone -- at the centre of the Ebola outbreak in May -- has been under quarantine for three months as the cocoa harvest comes in. Duration: 01:32 Video provided by AFP
Powered by NewsLook.com
Don't Fall For Flu Shot Myths

Don't Fall For Flu Shot Myths

Newsy (Nov. 23, 2014) Misconceptions abound when it comes to your annual flu shot. Medical experts say most people older than 6 months should get the shot. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins