Featured Research

from universities, journals, and other organizations

Cell-regulating Gene May Predict Survival Outcomes For Breast Cancer Patients

Date:
September 16, 2006
Source:
The Mount Sinai Hospital / Mount Sinai School of Medicine
Summary:
A study led by researchers at Mount Sinai School of Medicine has shown that a cell-regulating gene overexpressed in about 30 to 50 percent of all breast cancers is associated with a better chance of survival and increased sensitivity to a cancer-fighting drug.

A study led by researchers at Mount Sinai School of Medicine has shown that a cell-regulating gene overexpressed in about 30 to 50 percent of all breast cancers is associated with a better chance of survival and increased sensitivity to a cancer-fighting drug. The study appears in the September 6 issue of Journal of the National Cancer Institute.

Related Articles


Using mouse models, in vivo and in vitro tests revealed that the overexpression of a cell-regulating gene called cyclin D1 may actually be advantageous for some breast cancer patients because it suppresses the activity of another gene--STAT3--which promotes cell overgrowth and prevents harmful cells from dying, explains Doris Germain, PhD, Assistant Professor of Medicine.

Dr. Samuel Waxman, the Albert A. and Vera G. List Professor of Medicine, and Clinical Professor of Medicine (Hematology and Medical Oncology) and Oncological Sciences, Yuki Ishii, PhD, the study's first author and a post-doctoral fellow in molecular oncology, and Dr. Germain, collaborated with colleagues from Mount Sinai, and researchers from the Dana-Farber Cancer Institute in Boston and the Peter MacCallum Cancer Centre in Melbourne, Australia. They found that high levels of cyclin D1 increases sensitivity to bortezomib, a recently approved FDA drug used to treat multiple myeloma. The findings indicate that cyclin D1 could be a potential biological marker to help clinicians predict which breast cancer patients would respond favorably to bortezomib.

"Tumors occur because of a lack of control over cellular division," Dr. Germain explains. "Cyclin D1 promotes cell growth so you would think it would be an advantage to the tumor. But instead, we found that when cyclin D1 is overexpressed, it blocks STAT3. So cyclin D1 is inhibiting STAT3, which in turn, keeps the cancer from developing further."

Repressing STAT3 also increased a breast tumor's sensitivity to bortezomib, adds Dr. Waxman, indicating that bortezomib may be an alternative for women whose breast cancer has high levels of cyclin D1. "Our study provides a potential explanation for the beneficial effect of cyclin D1 in breast cancer and suggests that by amplifying this effect, bortezomib may be a useful treatment," he says. "A genetic profile of a patients' breast tumors could yield a great deal of information and help clinicians create more targeted treatments for their patients."

The findings were a surprise, Dr. Waxman says, because previous studies had suggested that the overexpression of cyclin D1 was associated with a poor prognosis in other types of cancers, including pancreatic cancer. Dr. Waxman says more research is needed to ascertain which groups of women have overexpressed cyclin D1. Clinical trials could then determine whether bortezomib would benefit these patients, he adds.


Story Source:

The above story is based on materials provided by The Mount Sinai Hospital / Mount Sinai School of Medicine. Note: Materials may be edited for content and length.


Cite This Page:

The Mount Sinai Hospital / Mount Sinai School of Medicine. "Cell-regulating Gene May Predict Survival Outcomes For Breast Cancer Patients." ScienceDaily. ScienceDaily, 16 September 2006. <www.sciencedaily.com/releases/2006/09/060915205116.htm>.
The Mount Sinai Hospital / Mount Sinai School of Medicine. (2006, September 16). Cell-regulating Gene May Predict Survival Outcomes For Breast Cancer Patients. ScienceDaily. Retrieved April 1, 2015 from www.sciencedaily.com/releases/2006/09/060915205116.htm
The Mount Sinai Hospital / Mount Sinai School of Medicine. "Cell-regulating Gene May Predict Survival Outcomes For Breast Cancer Patients." ScienceDaily. www.sciencedaily.com/releases/2006/09/060915205116.htm (accessed April 1, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, April 1, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Wound-Healing Laser Soon to Be a Reality Israeli Scientist

Wound-Healing Laser Soon to Be a Reality Israeli Scientist

Reuters - Innovations Video Online (Apr. 1, 2015) Israeli scientists says laser bonding of tissue allows much faster healing and less scarring. Amy Pollock has more. Video provided by Reuters
Powered by NewsLook.com
Liberia Sees Resurgence of Drug Trafficking as Ebola Wanes

Liberia Sees Resurgence of Drug Trafficking as Ebola Wanes

AFP (Apr. 1, 2015) The governments of Liberia and Sierra Leone have been busy fighting the menace created by the deadly Ebola virus, but illicit drug lords have taken advantage of the situation to advance the drug trade. Duration: 01:12 Video provided by AFP
Powered by NewsLook.com
Stigma Stalks India's Leprosy Sufferers as Disease Returns

Stigma Stalks India's Leprosy Sufferers as Disease Returns

AFP (Apr. 1, 2015) The Indian government declared victory over leprosy in 2005, but the disease is making a comeback in some parts of the country, with more than a hundred thousand lepers still living in colonies, shunned from society. Duration: 02:41 Video provided by AFP
Powered by NewsLook.com
7-Year-Old Girl Gets 3-D Printed 'robohand'

7-Year-Old Girl Gets 3-D Printed 'robohand'

AP (Mar. 31, 2015) Although she never had much interest in prosthetic limbs before, Faith Lennox couldn&apos;t wait to slip on her new robohand. The 7-year-old, who lost part of her left arm when she was a baby, grabbed it as soon as it came off a 3-D printer. (March 31) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins