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Elasticity Of Tissue Environment Plays Role In Determining Stem Cell Growth

Date:
September 20, 2006
Source:
American Chemical Society
Summary:
Researchers at the University of Pennsylvania have shown that the elasticity of a stem cell's environment is a major determinant of what type of tissue the stem cell becomes.

Researchers at the University of Pennsylvania have shown that the elasticity of a stem cell's environment is a major determinant of what type of tissue the stem cell becomes.

In laboratory tests, Dennis Discher and Adam Engler grew mesenchymal stem cells (derived from adult bone marrow) in polymer hydrogels with either soft, medium or rigid elasticity.

Based on resulting cell shapes as well as messenger RNA and protein markers, stem cells grown in softer environments -- such as brain tissue -- tended to produce nerve-like cells; those grown in environments with medium elasticity -- similar to muscle -- produced muscle-like cells

The stem cells grown in more rigid environments -- like bone -- produced bone-like cells.

The study provides new clues on how chemical and mechanical factors interact to influence stem cell growth, the researchers say.


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The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


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American Chemical Society. "Elasticity Of Tissue Environment Plays Role In Determining Stem Cell Growth." ScienceDaily. ScienceDaily, 20 September 2006. <www.sciencedaily.com/releases/2006/09/060918201126.htm>.
American Chemical Society. (2006, September 20). Elasticity Of Tissue Environment Plays Role In Determining Stem Cell Growth. ScienceDaily. Retrieved October 20, 2014 from www.sciencedaily.com/releases/2006/09/060918201126.htm
American Chemical Society. "Elasticity Of Tissue Environment Plays Role In Determining Stem Cell Growth." ScienceDaily. www.sciencedaily.com/releases/2006/09/060918201126.htm (accessed October 20, 2014).

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