Featured Research

from universities, journals, and other organizations

Super Chow, Laced With Semi-synthetic Vitamin E Derivative, Inhibited Spread Of Cancer In Mice

Date:
October 2, 2006
Source:
American Association for Cancer Research
Summary:
A chemically altered form of vitamin E mixed into mouse chow dramatically reduced spread of aggressive mammary cancer in mice, suggesting that the compound in pill form could be used to treat human metastatic cancer, according to a report in the October 1 issue of the journal Cancer Research.

A chemically altered form of vitamin E mixed into mouse chow dramatically reduced spread of aggressive mammary cancer in mice, suggesting that the compound in pill form could be used to treat human metastatic cancer, according to a report in the October 1 issue of the journal Cancer Research.

The study, by investigators at the University of Arizona, is the first to show that the synthetic compound has potent anti-cancer properties when given in the simplest way possible - as a dietary supplement.

"We tried other ways of delivering different forms of the synthetic vitamin, such as by force feeding and injections, but found that one form, -TEA, was more effective when incorporated into food, and that makes it much more clinically useful," said the study's lead investigator, Emmanuel T. Akporiaye, Ph.D., professor in the Department of Immunobiology at the University of Arizona.

Mice eating the super chow had a 4.8-fold reduction in the number of tumors that spread to the lungs, compared to control mice, Akporiaye said. An even greater effect was seen when the animals began eating -TEA-laced food as a cancer preventive, he said.

"These preliminary studies are very promising, and it could be that combining this synthetic vitamin E derivative with other anti-cancer treatments may offer the potential of both treating and preventing human breast cancer," Akporiaye said.

Although vitamin E (alpha tocopherol) is an anti-oxidant, it cannot destroy tumor cells by itself, he said. To improve the vitamin, derivatives have been created by swapping a hydroxyl chemical group with an acid. One is alpha-tocopheryl succinate (-TOS), which used a succinic acid residue, and another is alpha-tocopheryloxyacetic acid (-TEA), which used acetic acid.

Replacing the hydroxyl group in vitamin E helps force cancer cells to self destruct, Akporiaye said, because the compounds work to free up pro-apoptotic proteins that are normally held in check within cells. "Cell survival is maintained when pro-apoptotic proteins are confined, and these synthetic forms of vitamin E release them, pushing the cell into committing suicide," he said.

"Only a little part of vitamin E is changed in these synthetic derivatives, but they show amazing anticancer properties, and they selectively target tumor cells," Akporiaye said.

To make the synthetic vitamins water soluble (not fat soluble like natural vitamin E), researchers have added sodium hydroxide. In this way, these vesiculated forms, called V-TOS and V-TEA, can be delivered clinically through injection or oral gavage (feeding through a tube), and experiments have shown they can treat melanoma, lung and breast cancer in rodent models.

In this study, the Arizona researchers evaluated the anti-tumor effect of V-TOS and V-TEA on mice with an aggressive form of mammary cancer that is similar to human breast cancer that readily metastasizes. They also looked at how well -TEA would affect tumor growth if incorporated into the food ("chow") that the mice ate.

They found that injecting V-TOS or V-TEA into the peritoneal cavity of the mice reduced the average volume of tumors by two fold, compared to control mice that did not receive the injections. Administering V-TOS daily through a feeding tube had the same effect on tumor size, but V-TOS was ineffective when delivered in this way, Akporiaye said. "We found that V-TOS wasn't stable, and returned to its natural vitamin E state," he said.

To gauge the effectiveness of a dietary treatment, the researchers had special rat chow manufactured that incorporated a fairly large quantity of -TEA into the food. They then tested the chow as a cancer preventive and as a cancer treatment.

For the prevention study, the mice ate -TEA chow starting on the same day that they were injected with rodent mammary tumor cells known to spread quickly to the lungs and bones. The mice were allowed to eat as much food as they wanted, and at the end of 29 days, the average tumor volume was reduced by 6.7-fold, compared to control mice who had not been fed -TEA.

In the therapy experiment, mice started eating -TEA chow 11 days after tumors were implanted, and in the experimental group, there was a 3.6-fold reduction in average tumor volume compared to control mice, Akporiaye said.

In both preventive and therapeutic studies, mice fed -TEA chow had a 4.8-fold reduction in the number of tumors that had spread to the lungs, compared to control mice. "The results were very impressive," he said. "The chow was very effective in slowing down the growth rate of the tumor and significantly reducing metastases."

The -TEA diet produced no visible adverse side effects, not even weight loss, Akporiaye said.

"The combined characteristics of ease of delivery, relevance of route of delivery and selectivity for killing tumor cells suggest that dietary -TEA may be useful for treating metastatic breast cancer," he said.

The researchers are now testing the effect of reduced doses of -TEA in the chow and plan to test the synthetic vitamin in combination with dendritic cell immunotherapy. "When you kill tumor cells, they release antigens that can be picked up by specialized cells that stimulate the immune system,, and this two-step process could provide a longer lasting outcome," Akporiaye said.


Story Source:

The above story is based on materials provided by American Association for Cancer Research. Note: Materials may be edited for content and length.


Cite This Page:

American Association for Cancer Research. "Super Chow, Laced With Semi-synthetic Vitamin E Derivative, Inhibited Spread Of Cancer In Mice." ScienceDaily. ScienceDaily, 2 October 2006. <www.sciencedaily.com/releases/2006/10/061002154701.htm>.
American Association for Cancer Research. (2006, October 2). Super Chow, Laced With Semi-synthetic Vitamin E Derivative, Inhibited Spread Of Cancer In Mice. ScienceDaily. Retrieved September 16, 2014 from www.sciencedaily.com/releases/2006/10/061002154701.htm
American Association for Cancer Research. "Super Chow, Laced With Semi-synthetic Vitamin E Derivative, Inhibited Spread Of Cancer In Mice." ScienceDaily. www.sciencedaily.com/releases/2006/10/061002154701.htm (accessed September 16, 2014).

Share This



More Health & Medicine News

Tuesday, September 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Man Floats for 31 Hours in Gulf Waters

Man Floats for 31 Hours in Gulf Waters

AP (Sep. 16, 2014) A Texas man is lucky to be alive after he and three others floated for more than a day in the Gulf of Mexico when their boat sank during a fishing trip. (Sept. 16) Video provided by AP
Powered by NewsLook.com
Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

AFP (Sep. 16, 2014) Since the arrival of Ebola in Ivory Coast, Ivorians have been abandoning their pets, particularly monkeys, in the fear that they may transmit the virus. Duration: 00:47 Video provided by AFP
Powered by NewsLook.com
Study Links Male-Pattern Baldness To Prostate Cancer

Study Links Male-Pattern Baldness To Prostate Cancer

Newsy (Sep. 16, 2014) New findings suggest men with a certain type of baldness at age 45 are 39 percent more likely to develop aggressive prostate cancer. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

      Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins