Featured Research

from universities, journals, and other organizations

Blood Pressure Drugs Could Help Halt Pancreatic Cancer Spread, Researchers Find

Date:
December 8, 2006
Source:
Thomas Jefferson University
Summary:
Common blood pressure medications might help block the spread of pancreatic cancer, researchers have found. The scientists showed in laboratory studies that two types of pressure-lowering drugs -- ACE inhibitors and AT1R blockers -- may help reduce the development of tumor-feeding blood vessels, a process called angiogenesis. Such drugs, they say, may become part of a novel strategy to control the growth and spread of cancer.

Common blood pressure medications might help block the spread of pancreatic cancer, researchers at the Kimmel Cancer Center at Thomas Jefferson University in Philadelphia have found. The scientists showed in laboratory studies that two types of pressure-lowering drugs -- ACE inhibitors and AT1R blockers -- may help reduce the development of tumor-feeding blood vessels, a process called angiogenesis. Such drugs, they say, may become part of a novel strategy to control the growth and spread of cancer.

Related Articles


According to Hwyda Arafat, M.D., Ph.D., assistant professor of surgery at Jefferson Medical College, previous studies have linked a lower cancer incidence with the inhibition of the pancreas hormone angiotensin II (Ang II) by either ACE (Angiotensin I converting enzyme) inhibitors or AT1R (Ang II type 1 receptor) blockers. Ang II increases the production of VEGF, a vascular factor that promotes blood vessel growth in a number of cancers. High VEGF levels have been correlated with poor cancer prognosis and early recurrence. ACE is the enzyme that converts Ang I to Ang II.

Dr. Arafat and her co-workers examined the protein of both invasive pancreatic cancer and normal pancreatic tissue, analyzing the expression of ACE and AT1R in relation to VEGF. They also looked at the effects of blood pressure drugs captopril, an ACE inhibitor, and losartan, an AT1R blocker, on VEGF production in cancer cell lines.

They found that protein levels in ACE and AT1R were significantly higher in 75 percent of the cancer tissue examined. VEGF expression was higher in cases where there was strong ACE and AT1R levels. In the test tube, Ang II significantly enhanced VEGF production in AT1R-positive cells. Captopril and losartan both blocked this effect.

"Our data show for the first time that both ACE and AT1R are functionally expressed in pancreatic ductal adenocarcinoma and suggest their involvement in tumor angiogenesis," Dr. Arafat says. She presents her results December 5, 2006 at the Southern Surgical Association meeting in Palm Beach, FL.

"High VEGF levels correspond with lymph node metastasis and worse prognosis in many cancers," Dr. Arafat says. "High levels of angiotensin II might mean high levels of VEGF and pancreatic cancer. We have a treatment to block it."

"We are continuing to analyze how angiotensin affects VEGF, and the signaling pathways involved," she says. Her team is looking at the effect of angiotensin on cell proliferation and programmed cell death, and would like to develop an animal model.

"Patients have chemotherapy and radiation sometimes before surgery," she says. "I would imagine this would be useful either for unresectable tumors or after surgical removal of the pancreatic cancer. It might be used in maintenance."

"These are well tested, safe drugs," Dr. Arafat notes, "so the translation of our work from the animal model to the clinical trial can be fast. This is very promising." Pancreatic cancer is the fourth leading cause of cancer death in the United States, with some 32,000 deaths a year. Only five percent of patients live at least one year after diagnosis.


Story Source:

The above story is based on materials provided by Thomas Jefferson University. Note: Materials may be edited for content and length.


Cite This Page:

Thomas Jefferson University. "Blood Pressure Drugs Could Help Halt Pancreatic Cancer Spread, Researchers Find." ScienceDaily. ScienceDaily, 8 December 2006. <www.sciencedaily.com/releases/2006/12/061208101536.htm>.
Thomas Jefferson University. (2006, December 8). Blood Pressure Drugs Could Help Halt Pancreatic Cancer Spread, Researchers Find. ScienceDaily. Retrieved November 24, 2014 from www.sciencedaily.com/releases/2006/12/061208101536.htm
Thomas Jefferson University. "Blood Pressure Drugs Could Help Halt Pancreatic Cancer Spread, Researchers Find." ScienceDaily. www.sciencedaily.com/releases/2006/12/061208101536.htm (accessed November 24, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, November 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Winter Can Cause Depression — Here's How To Combat It

Winter Can Cause Depression — Here's How To Combat It

Newsy (Nov. 23, 2014) Millions of American suffer from seasonal depression every year. It can lead to adverse health effects, but there are ways to ease symptoms. Video provided by Newsy
Powered by NewsLook.com
Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

AFP (Nov. 23, 2014) The arable district of Kenema in Sierra Leone -- at the centre of the Ebola outbreak in May -- has been under quarantine for three months as the cocoa harvest comes in. Duration: 01:32 Video provided by AFP
Powered by NewsLook.com
Don't Fall For Flu Shot Myths

Don't Fall For Flu Shot Myths

Newsy (Nov. 23, 2014) Misconceptions abound when it comes to your annual flu shot. Medical experts say most people older than 6 months should get the shot. Video provided by Newsy
Powered by NewsLook.com
WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins