Featured Research

from universities, journals, and other organizations

Uncovering A New Reason Why Patients Respond Differently To The Same Drug Dose

Date:
January 16, 2007
Source:
American Chemical Society
Summary:
Why does the standard dose of certain medications prove dangerously high for some patients and too low to produce beneficial effects in others? Scientists have added a previously unrecognized factor to the list of explanations (such as age, gender, diet and genetics) for this common problem of individual variability in response to drugs.

Why does the standard dose of certain medications prove dangerously high for some patients and too low to produce beneficial effects in others? Scientists have added a previously unrecognized factor to the list of explanations (such as age, gender, diet and genetics) for this common problem of individual variability in response to drugs.

Related Articles


Jeffrey P. Krise and Ryan S. Funk, at the University of Kansas, are reporting that variations in the body's production of hydrogen peroxide -- believed to serve as a signaling molecule at low levels -- can affect accumulation of drugs inside cells. Their study, which involved cultured human cells and a common anti-cancer drug, is scheduled for the Feb. 5, 2007, issue of the ACS's Molecular Pharmaceutics, a bi-monthly journal.

"The demonstrated correlation between hydrogen peroxide exposure and the concomitant increase in drug accumulation represents a substantial finding," the study reports.

"The results suggest that patients experiencing oxidative stress (or an increase in hydrogen peroxide levels) may have an increased response to a given dosage of a drug relative to a patient with decreased oxidative stress, or those patients chronically taking antioxidants [such as vitamins C or E] with their medications. This could be a very important factor in our continued efforts to provide more individualized dosing of drugs."

Hydrogen peroxide's effects could be especially important in about two dozen so-called narrow therapeutic index drugs (such as aminophylline, carbamazepine, lithium carbonate, phenytoin, theophylline and warfarin) for which very small changes in dosage level could cause either subtherapeutic or toxic results, they note.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Cite This Page:

American Chemical Society. "Uncovering A New Reason Why Patients Respond Differently To The Same Drug Dose." ScienceDaily. ScienceDaily, 16 January 2007. <www.sciencedaily.com/releases/2007/01/070115094244.htm>.
American Chemical Society. (2007, January 16). Uncovering A New Reason Why Patients Respond Differently To The Same Drug Dose. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2007/01/070115094244.htm
American Chemical Society. "Uncovering A New Reason Why Patients Respond Differently To The Same Drug Dose." ScienceDaily. www.sciencedaily.com/releases/2007/01/070115094244.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins