Featured Research

from universities, journals, and other organizations

New Technique For Extracting Cardiovascular Drug Ingredient From Plants

Date:
January 16, 2007
Source:
International Science And Technology Center, Russia
Summary:
The flora of the Earth is a huge inexhaustible "well" of remedies. There are over 12,000 species of medicinal plants and they have been used to treat many different illnesses for several thousands of years. However, using only herbal infusions is not enough to achieve a curative positive effect, medicines have to be obtained from vegetable raw materials and knowledge is required on the mechanism of its action. For example, to prepare the highly active cardiovascular medication digoxin effective methods have to be developed to extract medicinal substances -- glycosides.

The flora of the Earth is a huge inexhaustible "well" of remedies. There are over 12,000 species of medicinal plants and they have been used to treat many different illnesses for several thousands of years. However, using only herbal infusions is not enough to achieve a curative positive effect, medicines have to be obtained from vegetable raw materials and knowledge is required on the mechanism of its action.

For example, to prepare the highly active cardiovascular medication digoxin effective methods have to be developed to extract medicinal substances -- glycosides. Such a problem is solved successfully by scientists from the State Research Institute of Organic Chemistry and Technology under the direction of the Project Manager Galina Mikhailovna Komissarova and All-Russian Institute of Medical and Aromatic Herbs under the direction of the Corresponding Member Dyumaev Kirill Mikhailovich. The International Science and Technology Centre supports the scientific research.

During a 200-year history of the application of cardiac glycosides in medical practice views on the mechanism of their action and the methods of obtaining the medications of the series of cardiotonic glycosides have changed considerably. But one thing remains unchanged -- the application of cardiac glycosides at the initial or latent stage of heart failure can correct available functional cardiac abnormalities and prevent the development of obvious heart failure.

A number of patented methods of preparing digoxin from Digitalis lanata with the use of natural enzymes are presently available. However, these patented methods have a number of major shortcomings. "The most essential among them, - says Galina Mikhailovna Komissarova, - is low stability of the fermentation process owing to the quality of herbal raw materials". Secondly, toxic and explosive solvents, which are costly materials, are used in these methods. Besides, a great number of technological purification stages have to be performed to obtain the final medication; this is a very laborious process.

During project realization the developers from the State Scientific Centre "State Research Institute of Organic Chemistry and Technology" succeeded in avoiding all of the above shortcomings, owing to totally new techniques of growing, picking, drying and storing Digitalis lanata. The obtained plant raw materials are characterized by a stably high content of highly active enzymes. The technique of preparing digoxin by means of enzymatic degradation in aqueous media at 45oC was elaborated, with the process proceeding completely without hindrance to the subsequent extraction and cleaning stages.

The advantages of the proposed method are controlled standard conditions in aqueous media during the formation of digoxin and the modification of conventional stages of digoxin extraction.

The novelty and uniqueness of the proposed Project is that it proposes a method for controlling the activity of enzymes in the raw material; it is designed to facilitate the production of a protein concentrate with certain enzymatic activity, and examination of activity standards required for effectively performing the raw material fermentation stage in the production of digoxin. Using novel techniques, the developers have managed to obtain a test sample -- 50 grams of digoxin. In future it is planned to modernize the extraction and purification methods of cardiotonic glycosides and methods of analytical production control that will help to provide medical organizations with the necessary quantity of this medication and it will give people the chance to recover from this serious illness.


Story Source:

The above story is based on materials provided by International Science And Technology Center, Russia. Note: Materials may be edited for content and length.


Cite This Page:

International Science And Technology Center, Russia. "New Technique For Extracting Cardiovascular Drug Ingredient From Plants." ScienceDaily. ScienceDaily, 16 January 2007. <www.sciencedaily.com/releases/2007/01/070116094012.htm>.
International Science And Technology Center, Russia. (2007, January 16). New Technique For Extracting Cardiovascular Drug Ingredient From Plants. ScienceDaily. Retrieved April 19, 2014 from www.sciencedaily.com/releases/2007/01/070116094012.htm
International Science And Technology Center, Russia. "New Technique For Extracting Cardiovascular Drug Ingredient From Plants." ScienceDaily. www.sciencedaily.com/releases/2007/01/070116094012.htm (accessed April 19, 2014).

Share This



More Health & Medicine News

Saturday, April 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Nine-Month-Old Baby Can't Open His Mouth

Nine-Month-Old Baby Can't Open His Mouth

Newsy (Apr. 19, 2014) Nine-month-old Wyatt Scott was born with a rare disorder called congenital trismus, which prevents him from opening his mouth. Video provided by Newsy
Powered by NewsLook.com
'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins