Featured Research

from universities, journals, and other organizations

New Imaging Technique Tracks Traffic Patterns Of White Blood Cells

Date:
February 28, 2007
Source:
The Mount Sinai Hospital / Mount Sinai School of Medicine
Summary:
Researchers at Mount Sinai School of Medicine have just developed an advanced imaging technique to capture the movement of the microdomains of leukocytes or white blood cells.

Researchers at Mount Sinai School of Medicine have just developed an advanced imaging technique to capture the movement of the microdomains of leukocytes or white blood cells. Microdomains are restricted areas on the surface of the cells in which receptors and signaling molecules accumulate during cell activation. Using digital multi-channel videomicroscopy, researchers were able to view white blood cell subsets and their forming microdomains in the vascular system in real time. In the upcoming March issue of Nature Methods, the new research displays the migration and inner workings of white blood cells in the small veins and bone marrow of mice.

Related Articles


"Intravital micropscopy (IVM) has contributed enormously to the recent mechanistic advances in leukocyte trafficking," wrote Mount Sinai School of Medicine researchers lead author Elaine Y. Chiang, Andres Hidalgo, Jungshan Chang and Paul S. Frenette of the Department of Medicine's Immunobiology Center and Black Family Stem Cell Institute in New York. "Multichannel digital fluorescence videomicropscopy vastly improves on prior intravital observations of leukocyte behavior in vivo by allowing the near-simultaneous observation of cell surface markers and microdomains."

Researchers explored various mouse models including that of Sickle Cell disease which is a common inherited blood disorder in the United States, affecting 72,000 Americans according to the National Institutes of Health (NIH). Sickle Cell disease is a blood disorder that affects hemoglobin, a protein inside red blood cells that help carry oxygen throughout the body. Abnormal hemoglobin polymerizes, and red blood cells become sickle-shaped. Sickle-shaped red blood cells then clog blood vessels by sticking to white blood cells and depriving the body of needed oxygen.

Using this new imaging method, red blood cells in a mouse model of Sickle Cell disease were shown to interact specifically with neutrophils, a subset of inflammatory white blood cells. "The ease and rapidity of this method, and the abilty to combine it with current genetic labeling techniques will greatly aid investigations to elucidate in vivo imflammatory cell behavior, and provide a powerful tool for the development of therapeutics for these diseases," according to Mount Sinai researchers.

"Sickle cell anemia was the first disease characterized at the molecular level but there is still no treatment for the acute vascular occlusions which are the hallmark of the disease," said Mount Sinai researcher Dr. Paul S. Frenette. "In vivo imaging provides a window inside the body that allows us to see exactly which blood cells and which molecular constituents participate in the vascular occlusions. Advances in molecular imaging will likely lead to new targets for the treatment that will improve the life of patients afflicted by this terrible illness."

Mount Sinai's research was done in collaboration with the National Heart, Lung and Blood Institute (NHLBI) of the NIH.


Story Source:

The above story is based on materials provided by The Mount Sinai Hospital / Mount Sinai School of Medicine. Note: Materials may be edited for content and length.


Cite This Page:

The Mount Sinai Hospital / Mount Sinai School of Medicine. "New Imaging Technique Tracks Traffic Patterns Of White Blood Cells." ScienceDaily. ScienceDaily, 28 February 2007. <www.sciencedaily.com/releases/2007/02/070227171138.htm>.
The Mount Sinai Hospital / Mount Sinai School of Medicine. (2007, February 28). New Imaging Technique Tracks Traffic Patterns Of White Blood Cells. ScienceDaily. Retrieved October 23, 2014 from www.sciencedaily.com/releases/2007/02/070227171138.htm
The Mount Sinai Hospital / Mount Sinai School of Medicine. "New Imaging Technique Tracks Traffic Patterns Of White Blood Cells." ScienceDaily. www.sciencedaily.com/releases/2007/02/070227171138.htm (accessed October 23, 2014).

Share This



More Health & Medicine News

Thursday, October 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Fears Keep Guinea Hospitals Empty

Ebola Fears Keep Guinea Hospitals Empty

AP (Oct. 23, 2014) Fears of Ebola are keeping doctors and patients alike away from hospitals in the West African nation of Guinea. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
More People Diagnosed With TB In 2013, But There's Good News

More People Diagnosed With TB In 2013, But There's Good News

Newsy (Oct. 22, 2014) The World Health Organizations says TB numbers rose in 2013, but it's partly due to better detection and more survivors. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins