Featured Research

from universities, journals, and other organizations

Snake Venom As Therapeutic Treatment Of Cancer?

Date:
April 16, 2007
Source:
UroToday
Summary:
This certainly sounds unusual, but scientists report on the effectiveness of a snake venom toxin in the inhibition of androgen-independent prostate cancer in a recent issue of the journal Molecular Cancer Therapeutics.

This certainly sounds unusual, but Dr. Son and colleagues report on the effectiveness of the snake venom toxin (SVT) Vipera lebetina turanica in the inhibition of androgen-independent prostate cancer (AICAP) in the journal Molecular Cancer Therapeutics.

Related Articles


The molecular focus of this report was on nuclear factor ΚB (NF- ΚB), an anti-apoptotic transcriptional factor that is constitutively activated in AICAP cell lines. The scientists showed that SVT inhibited growth of AICAP cells lines PC-3 and DU145 with IC50's of 1.7 and 1.8ug/mL, respectively. This exceeded the IC50 in LNCaP, androgen-sensitive cells (9.1ug/mL). With increasing concentrations of SVT, the number of cells distributed in the S phase of the cell cycle decreased significantly compare with cells in other phases.

To investigate whether SVT can inactivate NF- ΚB and thus cause cells to undergo apoptosis, PC-3 cells treated with SVT for 24 hours were assessed. The SBR interacts with NF- ΚB signal molecules by a protein-protein interaction with the cysteine residues in the NF- ΚB molecules.

Culturing the cells with SVT reduced the constitutive activation of NF- ΚB. Interaction between SSVTVT and mutant gene constructs was suggestive that the cysteine residues are the targets of SVT in the NF- ΚB molecule. Expression of cell cycle regulatory proteins was also altered in the SVT treated cells with decreased expression of G2-M phase regulation protein cyclin B1 and proteins regulating G1 phase in the cells. The increase of apoptotic action was confirmed by the induction of caspase-3 and -9 activations by SVT.

These novel findings suggest that SVT can inhibit the growth of AICAP through the induction of cell death.

Article: Dong Ju Son, Mi Hee Park, Sang Jin Chae, Soon Ok Moon, Jae Woong Lee, Ho Sueb Song, Dong Cheul Moon, Sang Sun Kang, Young Ee Kwon, and Jin Tae Hong, Molecular Cancer Therapeutics, 2007; 6:675-683.


Story Source:

The above story is based on materials provided by UroToday. Note: Materials may be edited for content and length.


Cite This Page:

UroToday. "Snake Venom As Therapeutic Treatment Of Cancer?." ScienceDaily. ScienceDaily, 16 April 2007. <www.sciencedaily.com/releases/2007/04/070415133122.htm>.
UroToday. (2007, April 16). Snake Venom As Therapeutic Treatment Of Cancer?. ScienceDaily. Retrieved December 19, 2014 from www.sciencedaily.com/releases/2007/04/070415133122.htm
UroToday. "Snake Venom As Therapeutic Treatment Of Cancer?." ScienceDaily. www.sciencedaily.com/releases/2007/04/070415133122.htm (accessed December 19, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Friday, December 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Navy Unveils Robot Fish

Navy Unveils Robot Fish

Reuters - Light News Video Online (Dec. 18, 2014) The U.S. Navy unveils an underwater device that mimics the movement of a fish. Tara Cleary reports. Video provided by Reuters
Powered by NewsLook.com
Kids Die While Under Protective Services

Kids Die While Under Protective Services

AP (Dec. 18, 2014) As part of a six-month investigation of child maltreatment deaths, the AP found that hundreds of deaths from horrific abuse and neglect could have been prevented. AP's Haven Daley reports. (Dec. 18) Video provided by AP
Powered by NewsLook.com
When You Lose Weight, This Is Where The Fat Goes

When You Lose Weight, This Is Where The Fat Goes

Newsy (Dec. 17, 2014) Can fat disappear into thin air? New research finds that during weight loss, over 80 percent of a person's fat molecules escape through the lungs. Video provided by Newsy
Powered by NewsLook.com
The Hottest Food Trends for 2015

The Hottest Food Trends for 2015

Buzz60 (Dec. 17, 2014) Urbanspoon predicts whicg food trends will dominate the culinary scene in 2015. Mara Montalbano (@maramontalbano) has the story. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins