Featured Research

from universities, journals, and other organizations

Protein May Hold Key To Decreasing Organ Dysfunction Rates In Heart Transplants

Date:
April 28, 2007
Source:
Blackwell Publishing Ltd.
Summary:
A new study has identified a protein known as Lipocalin-2 as potentially responsible for regulating the body's inflammatory response during heart transplants. One of the major complications involved with many transplantations is the damage done to the transplanted heart during and immediately following surgery, known as ischemia and reperfusion.

A new study, led by Felix Aigner, M.D., has identified a protein known as Lipocalin-2 (Lcn-2) as potentially responsible for regulating the body’s inflammatory response during heart transplants. One of the major complications involved with many transplantations is the damage done to the transplanted heart during and immediately following surgery, known as ischemia and reperfusion (IR).

In particular, inflammatory cells infiltrate the donated heart, which then releases enzymes and other proteins that attack the transplanted tissue, and can seriously impair the viability of replacement organs and jeopardize the health of the patient. The identification of Lcn-2 could be a first step towards reducing this inflammatory response and increasing the success rate of heart transplants worldwide. The study appears in American Journal of Transplantation.

Building on earlier work, the study finds that Lcn-2 is released by inflammatory cells attacking transplanted hearts in mice, and suggests that the protein is responsible for attracting further inflammatory response. Inflammation was found to decrease dramatically in mice in which the production of Lcn-2 was genetically disabled.

The study also found elevated levels of Lcn-2 in the kidneys of mice that had undergone heart transplants, suggesting the protein’s possible involvement in the systemic response to IR. “The major goal of our research activities is therefore to understand the exact mechanisms of this injury concomitant to organ transplantation,” notes Aigner, stressing the value of this research to the development of new treatment options in organ transplantation.


Story Source:

The above story is based on materials provided by Blackwell Publishing Ltd.. Note: Materials may be edited for content and length.


Cite This Page:

Blackwell Publishing Ltd.. "Protein May Hold Key To Decreasing Organ Dysfunction Rates In Heart Transplants." ScienceDaily. ScienceDaily, 28 April 2007. <www.sciencedaily.com/releases/2007/04/070427145706.htm>.
Blackwell Publishing Ltd.. (2007, April 28). Protein May Hold Key To Decreasing Organ Dysfunction Rates In Heart Transplants. ScienceDaily. Retrieved September 19, 2014 from www.sciencedaily.com/releases/2007/04/070427145706.htm
Blackwell Publishing Ltd.. "Protein May Hold Key To Decreasing Organ Dysfunction Rates In Heart Transplants." ScienceDaily. www.sciencedaily.com/releases/2007/04/070427145706.htm (accessed September 19, 2014).

Share This



More Health & Medicine News

Friday, September 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Cost of Ebola

The Cost of Ebola

Reuters - Business Video Online (Sep. 18, 2014) As Sierra Leone prepares for a three-day "lockdown" in its latest bid to stem the spread of Ebola, Ciara Lee looks at the financial implications of fighting the largest ever outbreak of the disease. Video provided by Reuters
Powered by NewsLook.com
What HealthKit Bug Means For Your iOS Fitness Apps

What HealthKit Bug Means For Your iOS Fitness Apps

Newsy (Sep. 18, 2014) Apple has delayed the launch of the HealthKit app platform, citing a bug. Video provided by Newsy
Powered by NewsLook.com
U.S. Food Makers Surpass Calorie-Cutting Pledge

U.S. Food Makers Surpass Calorie-Cutting Pledge

Newsy (Sep. 18, 2014) Sixteen large food and beverage companies in the United States that committed to cut calories in their products far surpassed their target. Video provided by Newsy
Powered by NewsLook.com
Residents Vaccinated as Haiti Fights Cholera Epidemic

Residents Vaccinated as Haiti Fights Cholera Epidemic

AFP (Sep. 18, 2014) Haitians receive the second dose of the vaccine against cholera as part of the UN's vaccination campaign. Duration: 00:34 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins