Featured Research

from universities, journals, and other organizations

Lessons From Ovarian Cells Migration: The Three 'Ws' Of Ovarian Cancer Spreading

Date:
May 15, 2007
Source:
The FIRC Institute of Molecular Oncology Foundation
Summary:
Who must go? When to go? Where to go? During development ovarian cells migrate in a spacial-temporal coordinated way, responding to specific signals that determine which cells have to move, when they have to move, and where they have to go.

Who must go? When to go? Where to go? During development ovarian cells migrate in a spacial-temporal coordinated way, responding to specific signals that determine which cells have to move, when they have to move, and where they have to go. The same types of signals stimulate migration of ovarian cancer cells, which follow specific signals to move from the female genital tract towards the peritoneum and stroma, where they form metastases.

Related Articles


These findings were presented today (May 13th) by Denise Montell, Professor of Biological Chemistry at the Johns Hopkins University School of Medicine in Baltimore (Maryland), at the Workshop on Cell Migration: From Molecules to Organisms and Diseases promoted by the European School of Molecular Medicine (SEMM) and the University of Milan, in collaboration with IFOM – The FIRC Institute for Molecular Oncology of the Italian Foundation for Cancer Research, and IEO – European Institute of Oncology. Venue of the Workshop is the IFOM-IEO Campus (via Adamello, 16, Milan) that was recently opened and represents the biggest area dedicated to the oncological research in Europe.

Epithelial ovarian cancer (EOC) develops in the ovary, especially in the cells that cover the outer surface of this organ. As it scores 190,000 new cases each year worldwide (61,000 in Europe), it has fuelled intensive investigations all over the world. Denise Montell and her group have been studying cell migration for years, in the attempt to elucidate the key elements that govern their movement. To this purpose the scientists have set up a system called “border cells model”, employing fruit fly (Drosophila melanogaster) cells, which has led to the identification of specific regulatory signals that cells respond to. “Epithelial cells migrate in a way that is reminiscent of the migratory behavior of cancer cells - explains the scientists – and this moving is highly coordinated as it responds to extracellular signals present in the surrounding microenvironment. Using our experimental model we were able to identify three kinds of signals.”

They are:

  • When: steroid hormones dictate the time when cells must start moving;
  • Where: Growth Factors show them the right direction;
  • Who: compounds called cytokines determine which cells will acquire mobility.

“Each of these signals – continues Montell – must work together in order for the cells to proceed to their correct destination. But they are not the only ones”. Further investigations into the signaling pathway of ovarian cells, in fact, led Montell to identify Par-1 as a key gene that controls cells migration. “We found – says Montell – that Par-1 regulates the detachment of cells from the epithelium and a critical step in releasing the cells from the original tissue”. Along these lines, future goal of the scientists will be to determine whether Par-1 contributes to ovarian cancer metastasis, or that of other carcinomas.

“Basic science results such as Montell’s have great value – points out Marina Mione, head of the IFOM program Genetic control of cell migration in zebrafish, and member of the Workshop’s Scientific Committee – as they pave the way for future clinical application. Devising new therapeutic approaches implies previous acquisition of solid scientific baseline information. Moving from observations acquired in physiological conditions Montell opens a number of new avenues that will promote our understanding of pathological conditions.”


Story Source:

The above story is based on materials provided by The FIRC Institute of Molecular Oncology Foundation. Note: Materials may be edited for content and length.


Cite This Page:

The FIRC Institute of Molecular Oncology Foundation. "Lessons From Ovarian Cells Migration: The Three 'Ws' Of Ovarian Cancer Spreading." ScienceDaily. ScienceDaily, 15 May 2007. <www.sciencedaily.com/releases/2007/05/070514160306.htm>.
The FIRC Institute of Molecular Oncology Foundation. (2007, May 15). Lessons From Ovarian Cells Migration: The Three 'Ws' Of Ovarian Cancer Spreading. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2007/05/070514160306.htm
The FIRC Institute of Molecular Oncology Foundation. "Lessons From Ovarian Cells Migration: The Three 'Ws' Of Ovarian Cancer Spreading." ScienceDaily. www.sciencedaily.com/releases/2007/05/070514160306.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Texas Nurse Nina Pham Cured of Ebola

Texas Nurse Nina Pham Cured of Ebola

AFP (Oct. 25, 2014) — An American nurse who contracted Ebola while caring for a Liberian patient in Texas has been declared free of the virus and will leave the hospital. Duration: 01:01 Video provided by AFP
Powered by NewsLook.com
IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) — IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) — A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) — The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins