Featured Research

from universities, journals, and other organizations

Atypical Pathogen Treatment Vital In Hospitalized CAP Patients

Date:
May 16, 2007
Source:
American Thoracic Society
Summary:
Hospitalized patients with community-acquired pneumonia who received treatment regimens against atyical disease-causing pathogens reached clinical stability quicker, had fewer days of hospitalization and had lower mortality rates as a result of their disease, according to a large new study.

Hospitalized patients with community-acquired pneumonia (CAP) who received treatment regimens against atypical disease-causing pathogens reached clinical stability quicker, had fewer days of hospitalization, and had lower mortality rates as a result of their disease, according to a large new study.

The research results appear in the second issue for May 2007 of the American Journal of Respiratory and Critical Care Medicine, published by the American Thoracic Society.

Forest W. Arnold, D.O., of the Division of Infectious Diseases at the University of Louisville, and 13 associates found a 22 percent global incidence of atypical pneumonia infections in 4,337 patients. Atypical pneumonias are those diseases caused by organisms other than the so-called "typical" bacteria, viruses or fungi.

Atypical treatment was defined as the use of any antibiotic regimen that contained a macrolide, fluoroquinolone or tetracycline (all broad-spectrum antibiotics).

After dividing the world into four areas and using 2,208 patients listed in the Community-Acquired Pneumonia Organization (CAPO) database, the number of patients who received an atypical treatment regimen in Region I (North America) was 91 percent, with 74 percent in Region II (Europe), 53 percent in Region III (Latin America), and 10 percent in Region IV (Africa and Asia).

According to the authors, hospitalized patients treated with antimicrobials against atypical pathogens reduced the time to clinical stability from 3.7 days to 3.2; their hospital stay from 7.1 days to 6.1; total mortality from 11.1 percent to 7 percent; and CAP-related mortality from 6.4 percent to 3.8.

"This study indicates that, although the incidence of atypical pathogens is relatively similar in all regions of the world, there are significant differences in the proportion of patients who are treated with an empiric regimen that cover for atypical pathogens," said Dr. Arnold.

Guidelines from the U.S., Canada, Germany, Japan and parts of Latin America recommend using a regimen that covers atypical pathogens in all hospitalized patients with community-acquired pneumonia.

According to the American Thoracic Society guidelines for CAP, clinical stability is defined by the following factors: improved clinical signs (improved cough and shortness of breath), lack of fever for at least eight hours, a decrease by at least 10 percent from the previous day in the number of leukocytes (white blood cells), and the ability to take oral nourishment.

The authors point out that estimates show mortality may not be directly related to the pulmonary infection in up to half the hospitalized patients with CAP.

"Also, in ambulatory patients with CAP, the beneficial effect of antibiotics using atypical coverage is more difficult to recognize because the time to clinical stability in this population is not measured and mortality is a very rare outcome," said Dr. Arnold.


Story Source:

The above story is based on materials provided by American Thoracic Society. Note: Materials may be edited for content and length.


Cite This Page:

American Thoracic Society. "Atypical Pathogen Treatment Vital In Hospitalized CAP Patients." ScienceDaily. ScienceDaily, 16 May 2007. <www.sciencedaily.com/releases/2007/05/070515074751.htm>.
American Thoracic Society. (2007, May 16). Atypical Pathogen Treatment Vital In Hospitalized CAP Patients. ScienceDaily. Retrieved September 17, 2014 from www.sciencedaily.com/releases/2007/05/070515074751.htm
American Thoracic Society. "Atypical Pathogen Treatment Vital In Hospitalized CAP Patients." ScienceDaily. www.sciencedaily.com/releases/2007/05/070515074751.htm (accessed September 17, 2014).

Share This



More Health & Medicine News

Wednesday, September 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Man Floats for 31 Hours in Gulf Waters

Man Floats for 31 Hours in Gulf Waters

AP (Sep. 16, 2014) A Texas man is lucky to be alive after he and three others floated for more than a day in the Gulf of Mexico when their boat sank during a fishing trip. (Sept. 16) Video provided by AP
Powered by NewsLook.com
Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

AFP (Sep. 16, 2014) Since the arrival of Ebola in Ivory Coast, Ivorians have been abandoning their pets, particularly monkeys, in the fear that they may transmit the virus. Duration: 00:47 Video provided by AFP
Powered by NewsLook.com
Study Links Male-Pattern Baldness To Prostate Cancer

Study Links Male-Pattern Baldness To Prostate Cancer

Newsy (Sep. 16, 2014) New findings suggest men with a certain type of baldness at age 45 are 39 percent more likely to develop aggressive prostate cancer. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

      Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins