Featured Research

from universities, journals, and other organizations

Vitamin A Helps Reduce Wrinkles Associated With Natural Skin Aging

Date:
May 22, 2007
Source:
JAMA and Archives Journals
Summary:
Applying vitamin A to the skin appears to improve the wrinkles associated with natural aging and may help to promote the production of skin-building compounds.

Applying vitamin A to the skin appears to improve the wrinkles associated with natural aging and may help to promote the production of skin-building compounds, according to a new report.

The wrinkles and brown spots associated with aging appear first and most prominently on skin exposed to the sun, according to background information in the article. "Human skin not exposed to the sun also ages but less dramatically," the authors write. "In intrinsic, natural or chronological aging, skin loses its youthful appearance by becoming thinner, laxer and more finely wrinkled. These changes are readily appreciated by inspecting the upper inner arm." Thinner skin results from a reduced production of the protein collagen and may slow wound healing, presenting a public health issue. "Safe and effective therapies to reverse the atrophy of natural skin aging do not exist currently," the authors note.

Reza Kafi, M.D., then of the University of Michigan Medical School, Ann Arbor, and now of Stanford Medical School, Palo Alto, Calif., and colleagues assessed the effectiveness of vitamin A (retinol) lotion in 36 elderly individuals (average age 87 years). Researchers applied a lotion containing 0.4 percent retinol to participants' right or left upper inner arms, and lotion with no retinol to the other arm, up to three times a week for 24 weeks. Wrinkles, roughness and overall severity of aging were each graded on a scale from zero (none) to nine (severe) before treatment and two, four, eight, 16 and 24 weeks after beginning treatment. In addition, 4-millimeter biopsy specimens of skin were taken from both arms at the beginning and end of the 24-week treatment period.

A total of 23 individuals completed the full study and 13 withdrew from the study prior to completion. When the researchers included the individuals who had dropped out of the study by assuming their skin did not change after their last measurement, wrinkles, roughness and overall aging severity were all significantly reduced in the retinol-treated arm compared with the control arm. The skin biopsies revealed that the retinol increased the production of glycosaminoglycan and procollagen, structural components of the skin.

"Topical retinol improves fine wrinkles associated with natural aging," the authors conclude. "Significant induction of glycosaminoglycan, which is known to retain substantial water, and increased collagen production are most likely responsible for wrinkle effacement [reduction]. With greater skin matrix synthesis [production of compounds that form new skin], retinol-treated aged skin is more likely to withstand skin injury and ulcer formation along with improved appearance."

The research is described in the May issue of Archives of Dermatology, one of the JAMA/Archives journals. (Arch Dermatol. 2007;143:606-612)


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Cite This Page:

JAMA and Archives Journals. "Vitamin A Helps Reduce Wrinkles Associated With Natural Skin Aging." ScienceDaily. ScienceDaily, 22 May 2007. <www.sciencedaily.com/releases/2007/05/070521162324.htm>.
JAMA and Archives Journals. (2007, May 22). Vitamin A Helps Reduce Wrinkles Associated With Natural Skin Aging. ScienceDaily. Retrieved August 21, 2014 from www.sciencedaily.com/releases/2007/05/070521162324.htm
JAMA and Archives Journals. "Vitamin A Helps Reduce Wrinkles Associated With Natural Skin Aging." ScienceDaily. www.sciencedaily.com/releases/2007/05/070521162324.htm (accessed August 21, 2014).

Share This




More Health & Medicine News

Thursday, August 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Possible Ebola Patient in Isolation at California Hospital

Possible Ebola Patient in Isolation at California Hospital

Reuters - US Online Video (Aug. 20, 2014) — A patient who may have been exposed to the Ebola virus is in isolation at the Kaiser Permanente South Sacramento Medical Center. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Raw: World's Oldest Man Lives in Japan

Raw: World's Oldest Man Lives in Japan

AP (Aug. 20, 2014) — A 111-year-old Japanese was certified as the world's oldest man by Guinness World Records on Wednesday. Sakari Momoi, a native of Fukushima in northern Japan, was given a certificate at a hospital in Tokyo. (Aug. 20) Video provided by AP
Powered by NewsLook.com
Do More Wedding Guests Make A Happier Marriage?

Do More Wedding Guests Make A Happier Marriage?

Newsy (Aug. 20, 2014) — A new study found couples who had at least 150 guests at their weddings were more likely to report being happy in their marriages. Video provided by Newsy
Powered by NewsLook.com
Ebola-Hit Sierra Leone's Freetown a City on Edge

Ebola-Hit Sierra Leone's Freetown a City on Edge

AFP (Aug. 19, 2014) — Residents of Sierra Leone's capital voice their fears as the Ebola virus sweeps through west Africa. Duration: 00:56 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins