Featured Research

from universities, journals, and other organizations

Liver Cancer Patients With High Serum Levels Of Hepatitis B Virus Face Poorer Outcomes

Date:
June 5, 2007
Source:
John Wiley & Sons, Inc.
Summary:
Researchers report their findings from the first-ever study examining the prognostic value of serum HBV DNA levels for patients with liver cancer undergoing chemotherapy. They found that patients with high pre-chemotherapy levels of HBV DNA had a significantly increased incidence of severe hepatitis which was associated with the worst survival.

Researchers report their findings from the first-ever study examining the prognostic value of serum HBV DNA levels for patients with liver cancer undergoing chemotherapy. They found that patients with high pre-chemotherapy levels of HBV DNA had a significantly increased incidence of severe hepatitis which was associated with the worst survival.

HBV is associated with a more than 200-fold increase in risk of liver cancer. In areas where HBV is endemic, like China and the Far East, the great majority of cases of hepatocellular carcinoma (HCC) occur in individuals with the virus. For most patients whose cancer is inoperable, chemotherapy is one of the main treatment options, and still the prognosis is dismal. Survival is often measured in months.

Researchers, led by Winnie Yeo of the Chinese University of Hong Kong, examined the significance of pre-chemotherapy HBV DNA levels in the blood on the survival of HCC patients. They studied 188 patients participating in a phase III randomized controlled trial comparing two different chemotherapy regimens. One hundred and seventy patients (92 percent) had evidence of HBV infection. Of these, 125 had sera available to determine HBV DNA levels and were included in the study.

For each patient, the researchers measured the level of HBV DNA in the blood before the start of chemotherapy. They also gathered other potentially important prognostic information, like age, sex, total bilirubin and presence of cirrhosis. Over the course of each patient's treatment, the researchers monitored blood counts, renal and liver function and clinical signs and symptoms. They then performed statistical analysis to assess which factors might have influenced patient outcomes.

The median survival of all patients was 6.83 months. Patients with high pre-treatment HBV DNA had a significantly higher incidence of developing severe hepatitis during chemotherapy and had poorer survival. Other factors significantly affecting survival were high total bilirubin and HCV infection.

"The present study has shown that a pre-chemotherapy viral load higher than 10(5.65) copies per milliliter is associated with poorer survival in HCC patients with chronic HBV infection, and this association is independent of an individual's hepatic reserve, tumor and clinical factors," the authors report.

Though the study was limited by a small patient cohort, and the fact that all had advanced disease, the authors concluded, "Based on the present findings, the incorporation of anti-viral therapies to reduce HBV viral load should be considered as part of management for HCC patients undergoing chemotherapy."

Article: "Hepatitis B Viral Load Predicts Survival of HCC Patients Undergoing Systemic Chemotherapy," Yeo, Winnie; Mo, Frankie; Chan, Stephen; Leung, Nancy; Hui, Pun; Lam, WY; Mok, Tony; Lam, Kwok; Ho, Wing; Koh, Jane; Tang, Julian; Chan, Anthony; Chan, Paul. Hepatology; June 2007; (DOI: 10.1002/hep.21572).


Story Source:

The above story is based on materials provided by John Wiley & Sons, Inc.. Note: Materials may be edited for content and length.


Cite This Page:

John Wiley & Sons, Inc.. "Liver Cancer Patients With High Serum Levels Of Hepatitis B Virus Face Poorer Outcomes." ScienceDaily. ScienceDaily, 5 June 2007. <www.sciencedaily.com/releases/2007/06/070601102326.htm>.
John Wiley & Sons, Inc.. (2007, June 5). Liver Cancer Patients With High Serum Levels Of Hepatitis B Virus Face Poorer Outcomes. ScienceDaily. Retrieved August 29, 2014 from www.sciencedaily.com/releases/2007/06/070601102326.htm
John Wiley & Sons, Inc.. "Liver Cancer Patients With High Serum Levels Of Hepatitis B Virus Face Poorer Outcomes." ScienceDaily. www.sciencedaily.com/releases/2007/06/070601102326.htm (accessed August 29, 2014).

Share This




More Health & Medicine News

Friday, August 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Killer Amoeba Found in Louisiana Water System

Killer Amoeba Found in Louisiana Water System

AP (Aug. 28, 2014) State health officials say testing has confirmed the presence of a killer amoeba in a water system serving three St. John the Baptist Parish towns. (Aug. 28) Video provided by AP
Powered by NewsLook.com
Who Could Be Burnt by WHO's E-Cigs Move?

Who Could Be Burnt by WHO's E-Cigs Move?

Reuters - Business Video Online (Aug. 28, 2014) The World Health Organisation has called for the regulation of electronic cigarettes as both tobacco and medical products. Ciara Lee looks at the impact of the move on the tobacco industry. Video provided by Reuters
Powered by NewsLook.com
CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

Newsy (Aug. 28, 2014) CDC director Tom Frieden says the Ebola outbreak is even worse than he feared. But he also said there's still hope to contain it. Video provided by Newsy
Powered by NewsLook.com
How A 'Rule Of Thumb' Could Slow Down Drinking

How A 'Rule Of Thumb' Could Slow Down Drinking

Newsy (Aug. 28, 2014) A study suggests people who follow a "rule of thumb" when pouring wine dispense less than those who don't have a particular amount in mind. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins