Featured Research

from universities, journals, and other organizations

Fat Fish Put Obesity On The Hook

Date:
June 19, 2007
Source:
Federation of American Societies for Experimental Biology
Summary:
Everyone knows that eating lean fish helps slim waistlines, but researchers have found a new way fish can help eliminate obesity. Researchers now describe the first genetic model of obesity in a fish. Having this model should greatly accelerate the development of new drugs to help people lose weight and keep it off.

Everyone knows that eating lean fish helps slim waistlines, but researchers from the Center for the Study of Weight Regulation and Associated Disorders at Oregon Health and Science University in Portland, OR, have found a new way fish can help eliminate obesity. In a study to be published in the July 2007 print issue of The FASEB Journal, researchers describe the first genetic model of obesity in a fish. Having this model should greatly accelerate the development of new drugs to help people lose weight and keep it off.

According to corresponding author Roger Cone, "Being able to model human disorders like obesity in zebrafish allows scientists to understand the molecular basis of disease. This may ultimately increase the efficiency and power of the drug discovery process, thus bringing new medicines to the market faster and cheaper."

In the study, researchers caused obesity in zebrafish by introducing the same type of genetic mutation that causes severe obesity in humans. The genetic change blocks the activity of a receptor, the melanocortin-4 receptor, which is at the heart of a "device" in our brains called the "adipostat." The adipostat regulates body weight homeostatically, like the thermostat in a house, and works to keep long-term energy stores--a.k.a. body fat--constant. The adipostat is what makes it difficult for people to lose weight and keep it off.

"Americans--even children--are getting fat at an alarming rate," said Gerald Weissmann, MD, Editor-in-Chief of The FASEB Journal, "and with this model, we are a step closer to temporarily turning off or diminishing the fat-storing mechanisms that were once crucial to the survival of our species. The zebrafish has become a model animal for the study of many diseases because it has a backbone and because its genetics have been well described. This is one more example of how basic experimental biology -- zoology physiology and genetics in this case -- can be brought to bear on human problems."

According the U.S. Centers for Disease Control and Prevention, the prevalence of overweight and obesity have risen steadily over the past 30 years. Among adults aged 20--74 years the prevalence of obesity increased from 15.0% (1976--1980) to 32.9% (2003--2004). For children aged 2--5 years, the prevalence of overweight increased from 5.0% to 13.9%; for those aged 6--11 years, prevalence increased from 6.5% to 18.8%; and for those aged 12--19 years, prevalence increased from 5.0% to 17.4%.

Being overweight or obese increases the risk of many diseases and health conditions, including, but not limited to: hypertension, dyslipidemia, type 2 diabetes, coronary heart disease, stroke, gallbladder disease, osteoarthritis, sleep apnea and respiratory problems, and some types of cancer.


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Cite This Page:

Federation of American Societies for Experimental Biology. "Fat Fish Put Obesity On The Hook." ScienceDaily. ScienceDaily, 19 June 2007. <www.sciencedaily.com/releases/2007/06/070618145704.htm>.
Federation of American Societies for Experimental Biology. (2007, June 19). Fat Fish Put Obesity On The Hook. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2007/06/070618145704.htm
Federation of American Societies for Experimental Biology. "Fat Fish Put Obesity On The Hook." ScienceDaily. www.sciencedaily.com/releases/2007/06/070618145704.htm (accessed September 2, 2014).

Share This




More Health & Medicine News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

Newsy (Sep. 2, 2014) The U.N. says the problem is two-fold — quarantine zones and travel restrictions are limiting the movement of both people and food. Video provided by Newsy
Powered by NewsLook.com
Get on Your Bike! London Cycling Popularity Soars Despite Danger

Get on Your Bike! London Cycling Popularity Soars Despite Danger

AFP (Sep. 1, 2014) Wedged between buses, lorries and cars, cycling in London isn't for the faint hearted. Nevertheless the number of people choosing to bike in the British capital has doubled over the past 15 years. Duration: 02:27 Video provided by AFP
Powered by NewsLook.com
Can You Train Your Brain To Eat Healthy?

Can You Train Your Brain To Eat Healthy?

Newsy (Sep. 1, 2014) New research says if you condition yourself to eat healthy foods, eventually you'll crave them instead of junk food. Video provided by Newsy
Powered by NewsLook.com
We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins