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Can You Hear Me Now? Stem Cells Enhance Hearing Recovery

Date:
June 25, 2007
Source:
American Journal of Pathology
Summary:
Researchers have shown that bone marrow stem cells injected into a damaged inner ear can speed hearing recovery after partial hearing loss. Stem cell migration into the damaged area of the inner ear improved hearing of high frequency sound (40 kHz) by 23% compared to natural recovery in untreated animals.

Researchers have shown that bone marrow stem cells injected into a damaged inner ear can speed hearing recovery after partial hearing loss.

Hearing loss has many causes, including genetics, aging, and infection, and may be complete or partial. Such loss may involve damage to inner ear cells called cochlear fibrocytes, which are fundamental to inner ear function. Some natural regeneration of these cells can occur after acute damage, leading to partial recovery of temporary hearing loss. But could such restoration be enhanced by using bone marrow stem cells, which can differentiate into various tissue-specific cell types"

Dr. Tatsuo Matsunaga of National Tokyo Medical Center pursued this hypothesis by utilizing a well-characterized rat model of drug-induced hearing loss. This model specifically destroys cochlear fibrocytes and leads to acute hearing loss. Although partial recovery occurs over many weeks, high-frequency hearing remains extremely diminished. Using this system, the investigators examined whether direct administration of stem cells into the inner ear could restore the cochlear fibrocyte population and aid hearing recovery.

Stem cells injected into the inner ear survived in half of the injured rats, where they migrated away from the site of injection toward the injured region within the inner ear. These stem cells divided in the new environment and expressed several proteins necessary for hearing, suggesting tissue-specific differentiation. Further, transplanted cells that migrated to the damaged area of the inner ear displayed shape similar to that of cochlear fibrocytes.

Importantly, transplanted rats exhibited faster recovery from hearing loss, particularly in the high frequency range, which is difficult to restore by natural regeneration. Stem cell migration into the damaged area of the inner ear improved hearing of high frequency sound (40 kHz) by 23% compared to natural recovery in untreated animals.

This is the first report to demonstrate hearing recovery following stem cell transplantation into the inner ear. "Cell therapy targeting regeneration of the cochlear fibrocytes may therefore be a powerful strategy to cure sensorineural hearing loss that cannot be reversed by current therapies," state Dr. Matsunaga and colleagues.

This work was supported by grants from the Ministry of Health, Labor, and Welfare of Japan and the Japan Foundation for Aging and Health.

Reference: Kamiya K, Fujinami Y, Hoya N, Okamoto Y, Kouike H, Komatsuzaki R, Kusano R, Nakagawa S, Satoh H, Fujii M, Matsunaga T. Mesenchymal stem cell transplantation accelerates hearing recovery through the repair of injured cochlear fibrocytes. Am J Pathol 2007 171: 214-226


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The above story is based on materials provided by American Journal of Pathology. Note: Materials may be edited for content and length.


Cite This Page:

American Journal of Pathology. "Can You Hear Me Now? Stem Cells Enhance Hearing Recovery." ScienceDaily. ScienceDaily, 25 June 2007. <www.sciencedaily.com/releases/2007/06/070625080913.htm>.
American Journal of Pathology. (2007, June 25). Can You Hear Me Now? Stem Cells Enhance Hearing Recovery. ScienceDaily. Retrieved August 23, 2014 from www.sciencedaily.com/releases/2007/06/070625080913.htm
American Journal of Pathology. "Can You Hear Me Now? Stem Cells Enhance Hearing Recovery." ScienceDaily. www.sciencedaily.com/releases/2007/06/070625080913.htm (accessed August 23, 2014).

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