Featured Research

from universities, journals, and other organizations

Scientists Isolate Chemical In Curry That May Help Immune System Clear Plaques Found In Alzheimer's

Date:
July 17, 2007
Source:
University of California - Los Angeles
Summary:
Researchers isolated bisdemethoxycurcumin, the active ingredient of curcuminoids -- a natural substance found in turmeric root -- that may help boost the immune system in clearing amyloid beta, a peptide that forms the plaques found in Alzheimer's disease.

Ground turmeric in small bowl.
Credit: iStockphoto/Jenny Horne

Researchers have isolated bisdemethoxycurcumin, the active ingredient of curcuminoids -- a natural substance found in turmeric root -- that may help boost the immune system in clearing amyloid beta, a peptide that forms the plaques found in Alzheimer's disease. Using blood samples from Alzheimer's disease patients, researchers found that bisdemethoxycurcumin boosted immune cells called macrophages to clear amyloid beta.

Related Articles


In addition, researchers identified the immune genes associated with this activity.

The study provides more insight into the role of the immune system in Alzheimer's disease and points to a new treatment approach. Researchers say that it may be possible to test a patient's immune response with a blood sample in order to individualize treatment. The genes involved in the process, called MGAT III and Toll-like receptors, are also responsible for a number of other key functions in the immune system.

The results also suggest a new drug development approach for the disease that differs from the amyloid-beta vaccine. The new approach relies on the innate immune system, which is present at birth rather than on antibodies produced by B cells, which is a later developed part of the active immune system.

Authors of the study include Dr. Milan Fiala, a researcher with the David Geffen School of Medicine and the VA Greater Los Angeles Health Care System and Dr. John Cashman, director of the Human BioMolecular Research Institute (HBRI) in San Diego.

Cashman received study funding from the Alzheimer's Drug Discovery Foundation and Fiala from the Alzheimer's Disease Association.

The research appears in the July 16 early edition of the Proceedings of the National Academy of Sciences.


Story Source:

The above story is based on materials provided by University of California - Los Angeles. Note: Materials may be edited for content and length.


Cite This Page:

University of California - Los Angeles. "Scientists Isolate Chemical In Curry That May Help Immune System Clear Plaques Found In Alzheimer's." ScienceDaily. ScienceDaily, 17 July 2007. <www.sciencedaily.com/releases/2007/07/070716190856.htm>.
University of California - Los Angeles. (2007, July 17). Scientists Isolate Chemical In Curry That May Help Immune System Clear Plaques Found In Alzheimer's. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2007/07/070716190856.htm
University of California - Los Angeles. "Scientists Isolate Chemical In Curry That May Help Immune System Clear Plaques Found In Alzheimer's." ScienceDaily. www.sciencedaily.com/releases/2007/07/070716190856.htm (accessed October 24, 2014).

Share This



More Health & Medicine News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins