Featured Research

from universities, journals, and other organizations

Novel Approach For Rapid Identification And Development Of Malaria Vaccines

Date:
July 28, 2007
Source:
Public Library of Science
Summary:
Malaria is the world’s most frequent parasitic disease, affecting more than 100 countries in the tropical zones, mostly in Africa, and 40% of the world population, with more than a million deaths per year. The development of a vaccine constitutes a major scientific and health challenge. Recent research has established a novel approach for the rapid discovery and development of vaccine candidates.

Malaria is the world’s most frequent parasitic disease, affecting more than 100 countries in the tropical zones, mostly in Africa, and 40% of the world population, with more than a million deaths per year. As a consequence countries affected by malaria also tend to be economically disadvantaged.

Related Articles


The development of a vaccine constitutes a major scientific and health challenge. Research conducted at the Biochemistry Department of the University of Lausanne, Switzerland, has established a novel approach for the rapid discovery and development of vaccine candidates.

The malaria parasites injected through the bite of an infected female mosquito first develop in the liver and then in the blood. Clinical symptoms are associated with the latter stage and no vaccine is currently available.

The development of an antibody-based vaccine to stop the proliferation of the parasite in the blood is thus clearly needed. The few candidates already tested or in the development process were identified over 20 years ago.

Taking advantage of the recently sequenced parasite genome, together with bioinformatics and peptide synthesis, Dr Giampietro Corradin’s group, University of Lausanne, Switzerland, in close collaboration with Dr Andrey Kajava, University of Montpellier, France, has developed a novel approach for the rapid identification of malaria vaccine candidates.

This approach is based on a bioinformatics selection of hundreds of short -helical coiled coil protein segments (30-40 amino acids long) which are able to maintain their conformation once they are chemically synthesized. In the first round of selection, all of 95 peptides synthesized were shown to be recognized by sera from malaria immune donors.

Purified human antibodies specific to a dozen of these peptides could effectively inhibit parasite growth in vitro. Due to the rapidity of the identification and manufacturing process, time and cost to enter new vaccine candidates in clinical trials can be drastically reduced.

This research was conducted in collaboration with the Pasteur Institute, Paris, France, the Swiss Tropical Institute, Basel, Switzerland, CNLRP, Ouagadougou, Burkina Faso and the University of Valle, Cali, Colombia.

The paper appears in the July 25 issue of PLoS One.

Citation: Villard V, Agak GW, Frank G, Jafarshad A, Servis C, et al (2007) Rapid Identification of Malaria Vaccine Candidates Based on a-Helical Coiled Coil Protein Motif. PLoS ONE 2(7): e645. doi:10.1371/journal.pone.0000645 (http://www.plosone.org/doi/pone.0000645)


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Cite This Page:

Public Library of Science. "Novel Approach For Rapid Identification And Development Of Malaria Vaccines." ScienceDaily. ScienceDaily, 28 July 2007. <www.sciencedaily.com/releases/2007/07/070725093640.htm>.
Public Library of Science. (2007, July 28). Novel Approach For Rapid Identification And Development Of Malaria Vaccines. ScienceDaily. Retrieved October 31, 2014 from www.sciencedaily.com/releases/2007/07/070725093640.htm
Public Library of Science. "Novel Approach For Rapid Identification And Development Of Malaria Vaccines." ScienceDaily. www.sciencedaily.com/releases/2007/07/070725093640.htm (accessed October 31, 2014).

Share This



More Health & Medicine News

Friday, October 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

U.S. Ebola Response Measures Demonstrated

U.S. Ebola Response Measures Demonstrated

AP (Oct. 31, 2014) Officials in the Washington area showed off Ebola response measures being taken at Dulles International Airport and the National Institutes of Health. (Oct. 31) Video provided by AP
Powered by NewsLook.com
Fauci Says Ebola Risk in US "essentially Zero"

Fauci Says Ebola Risk in US "essentially Zero"

AP (Oct. 30, 2014) NIAID Director Anthony Fauci said the risk of Ebola becoming an epidemic in the U.S. is essentially zero Thursday at the Washington Ideas Forum. He also said an Ebola vaccine will be tested in West Africa in the next few months. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Nurse Defies Ebola Quarantine With Bike Ride

Nurse Defies Ebola Quarantine With Bike Ride

AP (Oct. 30, 2014) A nurse who vowed to defy Maine's voluntary quarantine for health care workers who treated Ebola patients followed through on her promise Thursday, leaving her home for an hour-long bike ride. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Pot-Infused Edibles Raise Concerns in Colorado

Pot-Infused Edibles Raise Concerns in Colorado

AFP (Oct. 30, 2014) Colorado may have legalized marijuana for recreational use, but the debate around the decision still continues, with a recent - failed - attempt to ban cannabis-infused edibles. Duration: 01:53 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins