Featured Research

from universities, journals, and other organizations

Gene Expression Pattern Could Lead To Improved Treatment Of Pediatric Septic Shock

Date:
July 27, 2007
Source:
Cincinnati Children's Hospital Medical Center
Summary:
Scientists have discovered a gene expression pattern that could lead to improved diagnosis and treatment of pediatric septic shock -- still a serious public health problem despite today's potent antibiotics and pediatric intensive care units.

A consortium of researchers headed by Cincinnati Children's Hospital Medical Center has discovered a gene expression pattern that could lead to improved diagnosis and treatment of pediatric septic shock -- still a serious public health problem despite today's potent antibiotics and pediatric intensive care units.

Related Articles


Consistent with Cincinnati Children's increased emphasis on personalized and predictive medicine -- where diagnosis and treatment coincide with a person's genetic predisposition -- the study involves the largest gene expression analysis to date of blood samples from children with septic shock. It found new evidence linking adverse clinical outcomes with the decreased expression of genes that encode proteins involved in zinc regulation. This unexpected finding suggests these proteins and zinc regulation could provide a target for therapeutic intervention to inhibit septic shock's progression to multiple organ failure.

"Zinc was not even on our radar screen for this disease process," said Dr. Hector Wong, M.D., professor of Pediatrics and director of Critical Care Medicine at Cincinnati Children's. "This study demonstrates the potential power of genomic medicine for discovery and the generation of novel hypotheses. We are ultimately interested in determining whether or not there are biologically significant gene expression profiles that distinguish survivors from non-survivors. The rationale is to discover novel biomarkers of poor outcome and novel therapeutic targets as means for developing more effective treatment strategies."

The study -- published in the July issue of Physiological Genomics -- and consortium were led by Dr. Wong. The paper describes how comparative gene expression analysis of blood samples from children identified 63 genes expressed differently in patients with septic shock. This includes two forms of metallothionein where higher levels of metallothionein and lower levels of zinc were associated with increased chance of death. A total of 57 children participated in the study, which used individual micro-array chips to analyze samples from 15 control patients without septic shock and 42 patients with septic shock, including nine fatal cases.

Researchers at Cincinnati Children's continue to investigate the potential for analyzing zinc levels as way to understand the biology of septic shock and allow for more effective therapeutic intervention. This includes the possibility of using zinc supplementation as a form of treatment.


Story Source:

The above story is based on materials provided by Cincinnati Children's Hospital Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Cincinnati Children's Hospital Medical Center. "Gene Expression Pattern Could Lead To Improved Treatment Of Pediatric Septic Shock." ScienceDaily. ScienceDaily, 27 July 2007. <www.sciencedaily.com/releases/2007/07/070726113255.htm>.
Cincinnati Children's Hospital Medical Center. (2007, July 27). Gene Expression Pattern Could Lead To Improved Treatment Of Pediatric Septic Shock. ScienceDaily. Retrieved December 20, 2014 from www.sciencedaily.com/releases/2007/07/070726113255.htm
Cincinnati Children's Hospital Medical Center. "Gene Expression Pattern Could Lead To Improved Treatment Of Pediatric Septic Shock." ScienceDaily. www.sciencedaily.com/releases/2007/07/070726113255.htm (accessed December 20, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, December 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins