Featured Research

from universities, journals, and other organizations

Link Found Between Crohn's Disease And E. Coli Bacteria

Date:
August 8, 2007
Source:
Cornell University
Summary:
Scientists have discovered that a novel group of E. coli bacteria -- containing genes similar to those described in uropathogenic and avian pathogenic E. coli and enteropathogenic bacteria such as salmonella, cholera and bubonic plague -- is associated with intestinal inflammation in patients with Crohn's disease.

FISH of ileal mucosa with probes against eubacteria (6-FAM, green) and E.coli (Cy3,red). In normal mucosa (A,B) E.coli (orange bacteria) are infrequent, and not closely associated with the mucosa. In Crohn's disease mucosa E.coli were observed in close association with the mucosa in ulcerated areas of high cellularity (C,D,E), and were invasive (F). Nuclei are blue (DAPI).
Credit: Dr. Kenneth Simpson

A team of Cornell University scientists from the College of Veterinary Medicine, Weill Cornell Medical College and the College of Agriculture and Life Sciences have discovered that a novel group of E. coli bacteria -- containing genes similar to those described in uropathogenic and avian pathogenic E. coli and enteropathogenic bacteria such as salmonella, cholera, bubonic plague -- is associated with intestinal inflammation in patients with Crohn's disease.

Related Articles


Crohn's disease, an incurable inflammatory disorder of the intestine -- most commonly found in the lower part of the small intestine called the ileum -- affects 1-in-1,000 people in Europe and North America. Thus far, gut bacteria have long been suspected in playing a pivotal role in the development of Crohn's disease, but the specific bacterial characteristics that drive the inflammatory response have remained elusive.

Researchers at Cornell examined possible causes for the disease in patients with Crohn's restricted to the ileum and the colon versus healthy individuals.

"Given that only about 20 percent of fecal bacteria can be cultured, our group adopted a broad culture-independent approach to target specific subgroups of bacteria for quantitative in situ analysis and culture based characterization," said Kenneth Simpson, professor of small animal medicine at the College of Veterinary Medicine.

"Our findings raise the possibility that a novel group of E. coli contains opportunistic pathogens that may be causally related to chronic intestinal inflammation in susceptible individuals. They suggest that an integrated approach that considers an individual's mucosa-associated flora in addition to disease phenotype and genotype may improve outcome."

The study found an increased level of E. coli bacteria in more inflamed areas of the small intestines instead of MAP, a bacterium related to tubercle bacillus that has been more commonly associated with Crohn's.

Reference: "Culture independent analysis of ileal mucosa reveals a selective increase in invasive Escherichia coli of novel phylogeny relative to depletion of Clostridiales in Crohn's disease involving the ileum" The ISME Journal: Multidisciplinary Journal of Microbial Ecology, July 12, 2007

The study was supported by an Ithaca Cornell-Weill Cornell Seed Grant.


Story Source:

The above story is based on materials provided by Cornell University. Note: Materials may be edited for content and length.


Cite This Page:

Cornell University. "Link Found Between Crohn's Disease And E. Coli Bacteria." ScienceDaily. ScienceDaily, 8 August 2007. <www.sciencedaily.com/releases/2007/08/070807172136.htm>.
Cornell University. (2007, August 8). Link Found Between Crohn's Disease And E. Coli Bacteria. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2007/08/070807172136.htm
Cornell University. "Link Found Between Crohn's Disease And E. Coli Bacteria." ScienceDaily. www.sciencedaily.com/releases/2007/08/070807172136.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Feast Your Eyes: Lamb Chop Sent Into Space from UK

Feast Your Eyes: Lamb Chop Sent Into Space from UK

Reuters - Light News Video Online (Nov. 25, 2014) Take a stab at this -- stunt video shows a lamb chop's journey from an east London restaurant over 30 kilometers into space. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Cambodian Capital's Only Working Elephant to Retire in Jungle

Cambodian Capital's Only Working Elephant to Retire in Jungle

AFP (Nov. 25, 2014) Phnom Penh's only working elephant was blessed by a crowd of chanting Buddhist monks Tuesday as she prepared for a life of comfortable jungle retirement after three decades of giving rides to tourists. Duration: 00:36 Video provided by AFP
Powered by NewsLook.com
Stray Dog Follows Adventure Racing Team for 6-Day Endurance Race

Stray Dog Follows Adventure Racing Team for 6-Day Endurance Race

Buzz60 (Nov. 24, 2014) A Swedish Adventure racing team travels to try and win a world title, but comes home with something way better: a stray dog that joined the team for much of the grueling 430-mile race. Jen Markham has the story. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins