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Battle Of The Bulge: What Controls How Much We Eat?

Date:
August 14, 2007
Source:
Journal of Clinical Investigation
Summary:
In simple terms, individuals become obese if they eat more calories than they burn. However, the molecular pathways that control feeding behavior and cellular energy expenditure are highly complex and not completely understood.
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In simple terms, individuals become obese if they eat more calories than they burn. However, the molecular pathways that control feeding behavior and cellular energy expenditure are highly complex and not completely understood.

In a study that appears online on August 9 in advance of publication in the September print issue of the Journal of Clinical Investigation, Clay Semenkovich and colleagues from Washington University School of Medicine, St. Louis, show that mice lacking a protein known as FAS in beta-islet cells in the pancreas and in the region of the brain known as the hypothalamus are lean because they eat less and move around more than normal mice.

These effects on behavior were associated with decreased signaling in the hypothalamus through a protein known as PPAR-alpha. Administration of a PPAR-alpha agonist into the hypothalamus increased the amount mice lacking FAS specifically in the beta-islet cells and in the hypothalamus ate but did not increase the amount normal mice ate. This study therefore identifies FAS-mediated activation of PPAR-alpha as a molecular pathway controlling feeding behavior in mice.

Article: Brain fatty acid synthase activates PPAR-alpha to maintain energy homeostasis


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Journal of Clinical Investigation. "Battle Of The Bulge: What Controls How Much We Eat?." ScienceDaily. ScienceDaily, 14 August 2007. <www.sciencedaily.com/releases/2007/08/070810210802.htm>.
Journal of Clinical Investigation. (2007, August 14). Battle Of The Bulge: What Controls How Much We Eat?. ScienceDaily. Retrieved April 28, 2015 from www.sciencedaily.com/releases/2007/08/070810210802.htm
Journal of Clinical Investigation. "Battle Of The Bulge: What Controls How Much We Eat?." ScienceDaily. www.sciencedaily.com/releases/2007/08/070810210802.htm (accessed April 28, 2015).

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