Featured Research

from universities, journals, and other organizations

Battle Of The Bulge: What Controls How Much We Eat?

Date:
August 14, 2007
Source:
Journal of Clinical Investigation
Summary:
In simple terms, individuals become obese if they eat more calories than they burn. However, the molecular pathways that control feeding behavior and cellular energy expenditure are highly complex and not completely understood.

In simple terms, individuals become obese if they eat more calories than they burn. However, the molecular pathways that control feeding behavior and cellular energy expenditure are highly complex and not completely understood.

In a study that appears online on August 9 in advance of publication in the September print issue of the Journal of Clinical Investigation, Clay Semenkovich and colleagues from Washington University School of Medicine, St. Louis, show that mice lacking a protein known as FAS in beta-islet cells in the pancreas and in the region of the brain known as the hypothalamus are lean because they eat less and move around more than normal mice.

These effects on behavior were associated with decreased signaling in the hypothalamus through a protein known as PPAR-alpha. Administration of a PPAR-alpha agonist into the hypothalamus increased the amount mice lacking FAS specifically in the beta-islet cells and in the hypothalamus ate but did not increase the amount normal mice ate. This study therefore identifies FAS-mediated activation of PPAR-alpha as a molecular pathway controlling feeding behavior in mice.

Article: Brain fatty acid synthase activates PPAR-alpha to maintain energy homeostasis


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Clinical Investigation. "Battle Of The Bulge: What Controls How Much We Eat?." ScienceDaily. ScienceDaily, 14 August 2007. <www.sciencedaily.com/releases/2007/08/070810210802.htm>.
Journal of Clinical Investigation. (2007, August 14). Battle Of The Bulge: What Controls How Much We Eat?. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2007/08/070810210802.htm
Journal of Clinical Investigation. "Battle Of The Bulge: What Controls How Much We Eat?." ScienceDaily. www.sciencedaily.com/releases/2007/08/070810210802.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Newsy (July 23, 2014) An 8-year-old boy helped his younger brother, who has a rare genetic condition that's confined him to a wheelchair, finish a triathlon. Video provided by Newsy
Powered by NewsLook.com
Thousands Who Can't Afford Medical Care Flock to Free US Clinic

Thousands Who Can't Afford Medical Care Flock to Free US Clinic

AFP (July 23, 2014) America may be the world’s richest country, but in terms of healthcare, the World Health Organisation ranks it 37th. Thousands turned out for a free clinic run by "Remote Area Medical" with a visit from the Governor of Virginia. Duration: 2:40 Video provided by AFP
Powered by NewsLook.com
Stone Fruit Listeria Scare Causes Sweeping Recall

Stone Fruit Listeria Scare Causes Sweeping Recall

Newsy (July 22, 2014) The Wawona Packing Company has issued a voluntary recall on the stone fruit it distributes due to a possible Listeria outbreak. Video provided by Newsy
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins