Featured Research

from universities, journals, and other organizations

Air Pollution Linked To Cardiovascular Risk Indices In Healthy Young Adults

Date:
August 16, 2007
Source:
American Thoracic Society
Summary:
Researchers in Taiwan have demonstrated for the first time that urban air pollution simultaneously affects key indicators of cardiovascular risk in young adults: inflammation, oxidative stress, coagulation and autonomic dysfunction.

Researchers in Taiwan have demonstrated for the first time that urban air pollution simultaneously affects key indicators of cardiovascular risk in young adults: inflammation, oxidative stress, coagulation and autonomic dysfunction.

The study, which appeared in the second issue for August of the American Journal of Respiratory and Critical Care Medicine, published by the American Thoracic Society, investigated the effect of common urban air pollutants on biological markers for inflammation, oxidative stress, coagulation and autonomic dysfunction in 76 healthy Taiwanese college students.

The researchers collected blood samples and performed electrocardiograms on each subject approximately every 30 days for the months of April, May and June in either 2004 or 2005. They then correlated the sample dates and time with monitoring data from a fixed-site air monitoring station on the students' campus. The concentrations of common urban air pollutants were averaged over 24, 48 and 72 hours.

They found significant increases in all indices of cardiovascular risk were associated with increased exposure to common pollutants. "This study provides evidence that urban air pollution is associated with systemic inflammation/oxidative stress, impairment of the fibrinogenic system, activation of blood coagulation and alterations in the autonomic nervous system in young, healthy humans," wrote the study's lead author Chang-Chuan Chan, Sc.D., of National Taiwan University's College of Public Health.

"Most pollution literature has shown affects in elderly people, and although there have been experiments in young subjects, epidemiological research has not found such significant effects in young people as with these students in Taiwan," said Benoit Nemery, M.D., Ph.D., professor in the division of pneumonology at the Catholic University of Leuvin in Belgium, who was not involved in the research.

Specifically, the investigators found that increases in high-sensitivity C-reactive protein (hs-CRP) (an indicator of risk for a cardiovascular event), 8-hydroxy-2'-deoxyguanosine (8-OHdG) (a marker of oxidative stress), fibrinogen (a coagulation factor), plasminogen activator fibrinogen inhibitor-1 (PAI-1) (a marker of inflammation) and decreases in heart rate variability (HRV) (a predictor of increased cardiovascular risk) were associated with increases in particulate matter, sulfate, nitrate, and ozone when they analyzed pollutants singly, and that increases in 8-OHdG, fibrinogen, and PAI-1 and decreases HRV were correlated to increased ozone and sulfate levels over three day averages in multi-pollutant models.

The precise biological mechanisms involved were not able to be determined with this study's design. "Further studies with more detailed measurements of cardiovascular endpoints over time are still needed to elucidate the time sequence of pollution effects on cardiovascular endpoints in humans," wrote Dr. Chang-Chuan Chan.

"Many questions remain to be answered," wrote Joel Kaufman, M.D., M.P. H., in the accompanying editorial, "[But] these questions should by no means slow the important efforts to reduce exposures and benefit global public health."


Story Source:

The above story is based on materials provided by American Thoracic Society. Note: Materials may be edited for content and length.


Cite This Page:

American Thoracic Society. "Air Pollution Linked To Cardiovascular Risk Indices In Healthy Young Adults." ScienceDaily. ScienceDaily, 16 August 2007. <www.sciencedaily.com/releases/2007/08/070815085429.htm>.
American Thoracic Society. (2007, August 16). Air Pollution Linked To Cardiovascular Risk Indices In Healthy Young Adults. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2007/08/070815085429.htm
American Thoracic Society. "Air Pollution Linked To Cardiovascular Risk Indices In Healthy Young Adults." ScienceDaily. www.sciencedaily.com/releases/2007/08/070815085429.htm (accessed July 31, 2014).

Share This




More Earth & Climate News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Big Waves In Arctic Ocean Threaten Polar Ice

Big Waves In Arctic Ocean Threaten Polar Ice

Newsy (July 30, 2014) Big waves in parts of the Arctic Ocean are unprecedented, mainly because they used to be covered in ice. Video provided by Newsy
Powered by NewsLook.com
Raw: Thousands Flocking to German Crop Circle

Raw: Thousands Flocking to German Crop Circle

AP (July 30, 2014) Thousands of people are trekking to a Bavarian farmer's field to check out a mysterious set of crop circles. (July 30) Video provided by AP
Powered by NewsLook.com
Amid Drought, UCLA Sees Only Water

Amid Drought, UCLA Sees Only Water

AP (July 30, 2014) A ruptured 93-year-old water main left the UCLA campus awash in 8 million gallons of water in the middle of California's worst drought in decades. (July 30) Video provided by AP
Powered by NewsLook.com
In Virginia, the Rise of a New Space Coast

In Virginia, the Rise of a New Space Coast

AP (July 30, 2014) Every summer, tourists make the pilgrimage to Chincoteague Island, Va. to see wild ponies cross the Assateague Channel. But, it's the rockets sending to supplies to the International Space Station that are making this a year-round destination. (July 30) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins