Featured Research

from universities, journals, and other organizations

'Fat Eggs' Causes Infertility In Obese Women

Date:
August 27, 2007
Source:
University of Adelaide
Summary:
A researcher has discovered scientific evidence that obesity is a key factor in infertility - because of how it affects women's eggs. While obesity has long been thought to be a major factor in couples' inability to conceive, this is the first time the effects of obesity on the egg have been discovered.

PhD student Cadence Minge in the Research Centre for Reproductive Health.
Credit: Image courtesy of University of Adelaide

A University of Adelaide researcher has discovered scientific evidence that obesity is a key factor in infertility - because of how it affects women's eggs.

While obesity has long been thought to be a major factor in couples' inability to conceive, this is the first time the effects of obesity on the egg have been discovered.

The research findings - using female mice - have been made by PhD student Cadence Minge in the University of Adelaide's Research Centre for Reproductive Health.

Importantly, her research has also discovered a way to completely reverse the effects of obesity on mouse eggs, enabling afflicted eggs to develop into healthy embryos.

"Consuming a diet high in fat causes damage to eggs stored in female ovaries. As a result, when fertilised these eggs are not able to undergo normal, healthy development into embryos," Ms Minge says.

Ms Minge has discovered that a protein in the cells surrounding, supporting and nourishing the egg - called Peroxisome Proliferator-Activated Receptor gamma (PPARγ) - is the main reason behind diet-induced infertility.

"The behaviour of this protein helps to determine the way in which the ovaries sense and respond to fats," Ms Minge says.

"Being able to control this protein will be very important in the quest to reverse infertility caused by poor diets."

Ms Minge's research has found that when the protein is selectively targeted with the anti-diabetes drug rosiglitazone (marketed as Avandia by GlaxoSmithKline), the adverse effects of obesity on egg quality are completely reversed.

"The drug enables us to switch on the protein, thereby changing the way in which the ovaries sense and respond to fats. Embryo development rates are restored, and the cellular differentiation of the early embryo is improved. In the long-term these improvements can result in increased birth weight and fetal survival," Ms Minge says.

However, Ms Minge warns that rosiglitazone should not be seen as a "quick fix" for infertile women.

"The rosiglitazone findings are of great significance for scientists researching egg maturation within the ovary. But at this stage, the research findings have only been made in mice. Also, the drug itself can have possible harmful side-effects, and more research is needed to find other, safer ways of activating the protein," she says.

"With more research, if we can pinpoint critical cellular controls of egg quality, it may allow women to maximise their likelihood of healthy conception."

Ms Minge says her findings emphasise the importance of a healthy lifestyle for women interested in conceiving children naturally.

"Despite the wide-ranging recognised health risks associated with excessive body weight, Australia's waistline continues to expand. Currently, Australia is on par with heavyweight nations such as the US and the UK, with approximately 60% of Australian adults now overweight or obese," Ms Minge says.

"I hope that these findings encourage people to carefully consider the impact of lifestyle choices on longer-term quality of life."


Story Source:

The above story is based on materials provided by University of Adelaide. Note: Materials may be edited for content and length.


Cite This Page:

University of Adelaide. "'Fat Eggs' Causes Infertility In Obese Women." ScienceDaily. ScienceDaily, 27 August 2007. <www.sciencedaily.com/releases/2007/08/070823182738.htm>.
University of Adelaide. (2007, August 27). 'Fat Eggs' Causes Infertility In Obese Women. ScienceDaily. Retrieved August 23, 2014 from www.sciencedaily.com/releases/2007/08/070823182738.htm
University of Adelaide. "'Fat Eggs' Causes Infertility In Obese Women." ScienceDaily. www.sciencedaily.com/releases/2007/08/070823182738.htm (accessed August 23, 2014).

Share This




More Health & Medicine News

Saturday, August 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Two US Ebola Patients Leave Hospital Free of the Disease

Two US Ebola Patients Leave Hospital Free of the Disease

AFP (Aug. 21, 2014) Two American missionaries who were sickened with Ebola while working in Liberia and were treated with an experimental drug are doing better and have left the hospital, doctors say on August 21, 2014. Duration: 01:05 Video provided by AFP
Powered by NewsLook.com
Cadavers, a Teen, and a Medical School Dream

Cadavers, a Teen, and a Medical School Dream

AP (Aug. 21, 2014) Contains graphic content. He's only 17. But Johntrell Bowles has wanted to be a doctor from a young age, despite the odds against him. He was recently the youngest participant in a cadaver program at the Indiana University NW medical school. (Aug. 21) Video provided by AP
Powered by NewsLook.com
American Ebola Patients Released: What Cured Them?

American Ebola Patients Released: What Cured Them?

Newsy (Aug. 21, 2014) It's unclear whether the American Ebola patients' recoveries can be attributed to an experimental drug or early detection and good medical care. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins