Featured Research

from universities, journals, and other organizations

DNA Provides Clues To Outcome In Patients With Liver Cancer

Date:
August 27, 2007
Source:
Journal of Clinical Investigation
Summary:
The main causes of liver cancer, which is the fifth most common cancer in the world, are well defined. However, the molecular pathways activated by the triggers of liver cancer are not well characterized. In a new study, scientists shed some light on this, showing that the extent to which the genome of a person's liver cancer cells is modified by a process known as methylation correlates with clinical outcome.

The main causes of liver cancer (also known as hepatocellular carcinoma [HCC]), which is the fifth most common cancer in the world, are well defined. However, the molecular pathways activated by the triggers of liver cancer are not well characterized.

Related Articles


In a new study, Snorri Thorgeirsson and colleagues from the National Institutes of Health, Bethesda, shed some light on this, showing that the extent to which the genome of a person's liver cancer cells is modified by a process known as methylation correlates with clinical outcome. They therefore suggest that preventing aberrant methylation or targeting the genes whose expression is altered by the aberrant methylation might provide new targets for the treatment of liver cancer.

Detailed analysis of the methylation status of the genome of human liver cells revealed that tumor cells could be identified from healthy cells by genome-wide hypomethylation and CpG hypermethylation.

Furthermore, greater genome-wide hypomethylation and CpG hypermethylation correlated with shorter survival. In addition, these changes in methylation were associated with selective inactivation of a number of genes, including inhibitors of Ras and some inhibitors of angiogenesis.

The authors therefore suggest that in individuals with liver cancer, analyzing the methylation status of the genome of their tumor cells might have prognostic value and that either modifying genome methylation or targeting the Ras pathway might have therapeutic value.

Article: Mechanistic and prognostic significance of aberrant methylation in the molecular pathogenesis of human hepatocellular carcinma


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Clinical Investigation. "DNA Provides Clues To Outcome In Patients With Liver Cancer." ScienceDaily. ScienceDaily, 27 August 2007. <www.sciencedaily.com/releases/2007/08/070823213905.htm>.
Journal of Clinical Investigation. (2007, August 27). DNA Provides Clues To Outcome In Patients With Liver Cancer. ScienceDaily. Retrieved November 25, 2014 from www.sciencedaily.com/releases/2007/08/070823213905.htm
Journal of Clinical Investigation. "DNA Provides Clues To Outcome In Patients With Liver Cancer." ScienceDaily. www.sciencedaily.com/releases/2007/08/070823213905.htm (accessed November 25, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, November 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com
Madagascar Working to Contain Plague Outbreak

Madagascar Working to Contain Plague Outbreak

AFP (Nov. 24, 2014) Madagascar said Monday it is trying to contain an outbreak of plague -- similar to the Black Death that swept Medieval Europe -- that has killed 40 people and is spreading to the capital Antananarivo. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com
Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins