Featured Research

from universities, journals, and other organizations

Alcoholics With Cirrhosis Of The Liver Have More Brain Damage Than Noncirrhotic Alcoholics

August 29, 2007
Alcoholism: Clinical & Experimental Research
Cirrhosis of the liver is one of the most common and serious medical complications linked to alcoholism. Heavy alcohol use can also cause brain damage. Cirrhotic alcoholics appear to have even more impaired brain function than noncirrhotic alcoholics.

Sustained exposure to alcohol can cause scarring and dysfunction of the liver, referred to as cirrhosis. Heavy alcohol use can also cause brain damage. An examination of gene expression in the frontal cortex has found that brain function is even more impaired in cirrhotic than non-cirrhotic alcoholics.

"The liver's main function is to remove poisons from the blood," explained R. Dayne Mayfield, research scientist at the Waggoner Center for Alcohol and Addiction Research at The University of Texas at Austin. "It also helps the body absorb certain nutrients like fats and fat-soluble vitamins. You cannot live without a functioning liver." Mayfield is also the corresponding author for the study.

He added that about 10 to 20 percent of heavy drinkers develop cirrhosis. It is the seventh leading cause of death among young and middle-aged adults in the United States; approximately 10,000 to 24,000 deaths from cirrhosis each year may be due to alcohol consumption. "Cirrhotic patients [have] dysfunctional livers that cannot remove poisons from the blood stream," he said. These poisons are able to move into the brain and disrupt normal function.

"When a gene or deoxyribonucleic acid (DNA) is 'turned on,'" said Mayfield, "it serves as a template for synthesis of ribonucleic acid (RNA), which in turn produces protein, the key element in cell function. These 'genes' hold the key or code for the ultimate production of proteins that control all functions of the brain. We know that heavy alcohol drinking changes the regulation of genes in the brain. We predicted that alcohol-related changes in brain genes would be magnified in alcoholics with cirrhosis."

Researchers obtained brain samples from the Brisbane Node of the National Health & Medical Research Council Brain Bank and the Tissue Resource Centre at the University of Sydney, Australia. They compared roughly 47,000 element cDNA microarrays taken from two groups (n=21): seven cirrhotic and 14 non-cirrhotic alcoholic cases.

"We found that the levels of many important brain genes changed in the cirrhotic patients," said Mayfield. "These genes are important in regulating cell death and how individual cells in the brain talk to each other in a meaningful way."

"The level of gene expression differed significantly between tissue from cirrhotic and non-cirrhotic alcoholics," added John H. Krystal, Robert L. McNeil, Jr. professor of clinical pharmacology and deputy chairman for research in the department of Psychiatry at Yale University School of Medicine and the VA Connecticut Healthcare System. "Out of 1,125 genes, 482 genes showed increased expression and 643 genes showed reduced expression in the cirrhotic individuals. With the levels of so many genes changing, this study suggests widespread effects in many cellular pathways related to cirrhosis in the alcoholic group." Krystal is also a principal investigator at the NIAAA Center for the Translational Neuroscience of Alcoholism and the VA Alcohol Research Center.

More specifically, those genes involved in neurite growth, neuronal cell adhesion, and synaptic transmission showed greater inhibition at the mRNA level among the alcoholic cases.

"Cells in the brain have to maintain connections in order to operate," explained Mayfield. "This is similar to the way the internet works to transmit information across the globe. The internet would slow down or stop if enough connections are interrupted or changed. Similarly, the genes outlined above are responsible for proper connections and communication between cells in the brain. Without them, normal function would not be possible."

Krystal suggested several possible interpretations of the findings. "One, alcoholics who develop cirrhosis likely drink more heavily than those alcoholics who do not develop cirrhosis," he said. "Therefore, some of the findings may be related to the effects of heavy drinking upon the brain. A second contribution could be the effects of impaired liver function upon the brain. The liver plays a major role in the production and metabolism of a large number of substances that influence brain function, and impaired liver function would be expected to affect the brain. A third possibility is that cellular processes that are stimulated by alcohol consumption might influence both liver and brain. That is, the cirrhotic and non-cirrhotic groups differ in their cellular resilience to the toxic effects of alcohol rather than differences in their level of alcohol consumption. A fourth possible contributing factor could be changes in diet. If patients with cirrhosis have a more profound disruption of their nutrition than patients who do not develop cirrhosis, differences in brain damage may be related to nutritional deficiencies."

Both Mayfield and Krystal said that the central message of the study is that alcoholism, especially when accompanied by a serious medical complication such as cirrhosis of the liver, can produce widespread changes in the body and brain.

"One hopes that a better understanding of the cellular processes related to the destructive impact of alcoholism upon the brain may help to guide the development of treatments that might protect people from neural damage related to alcoholism, and help them to recover from alcoholism," said Krystal. "Important questions are: 'How reversible are the changes in gene expression in the brain when alcoholics stop drinking"' and 'How dependent is the recovery of the brain upon the recovery of the liver"'"

Results are published in the September issue of Alcoholism: Clinical & Experimental Research.

Story Source:

The above story is based on materials provided by Alcoholism: Clinical & Experimental Research. Note: Materials may be edited for content and length.

Cite This Page:

Alcoholism: Clinical & Experimental Research. "Alcoholics With Cirrhosis Of The Liver Have More Brain Damage Than Noncirrhotic Alcoholics." ScienceDaily. ScienceDaily, 29 August 2007. <www.sciencedaily.com/releases/2007/08/070827161241.htm>.
Alcoholism: Clinical & Experimental Research. (2007, August 29). Alcoholics With Cirrhosis Of The Liver Have More Brain Damage Than Noncirrhotic Alcoholics. ScienceDaily. Retrieved September 21, 2014 from www.sciencedaily.com/releases/2007/08/070827161241.htm
Alcoholism: Clinical & Experimental Research. "Alcoholics With Cirrhosis Of The Liver Have More Brain Damage Than Noncirrhotic Alcoholics." ScienceDaily. www.sciencedaily.com/releases/2007/08/070827161241.htm (accessed September 21, 2014).

Share This

More Health & Medicine News

Sunday, September 21, 2014

Featured Research

from universities, journals, and other organizations

Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.


Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News


Free Subscriptions

Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile

Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?

Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins