Featured Research

from universities, journals, and other organizations

New Mouse Model Of Adult-onset Muscular Dystrophy Allows Disease Mechanisms To Be Determined

Date:
September 12, 2007
Source:
Journal of Clinical Investigation
Summary:
The most common form of adult-onset muscular dystrophy is myotonic dystrophin type 1 (DM1). DM1 is an inherited disease that has many symptoms including progressive muscle wasting and heart problems. Heart problems occur in most individuals with DM1 and account for a substantial proportion of disease-related deaths.

The most common form of adult-onset muscular dystrophy is myotonic dystrophin type 1 (DM1).

DM1 is an inherited disease that has many symptoms including progressive muscle wasting and heart problems. Heart problems occur in most individuals with DM1 and account for a substantial proportion of disease-related deaths.

In a new study, Thomas Cooper and colleagues at Baylor College of Medicine, Houston, describe how they have developed a mouse model of DM1 heart problems that has enabled them to garner more insight into the molecular mechanisms of the disease.

DM1 is characterized by an accumulation of RNA in the nucleus, which alters the functions of proteins known as CUGBPs causing aberrant alternative slicing of certain pre-mRNAs.

Using their new mouse model of DM1 Cooper and colleagues were able to show that upregulation of CUGBP1 correlated with alteration in alternative splicing patterns, indicating that this is an early step in the pathogenesis of DM1.

Article: Elevation of RNA-binding protein CUGBP1 is an early event in an inducible heart-specific mouse model of myotonic dystrophy, Journal of Clinical Investigation


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Clinical Investigation. "New Mouse Model Of Adult-onset Muscular Dystrophy Allows Disease Mechanisms To Be Determined." ScienceDaily. ScienceDaily, 12 September 2007. <www.sciencedaily.com/releases/2007/09/070906214953.htm>.
Journal of Clinical Investigation. (2007, September 12). New Mouse Model Of Adult-onset Muscular Dystrophy Allows Disease Mechanisms To Be Determined. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2007/09/070906214953.htm
Journal of Clinical Investigation. "New Mouse Model Of Adult-onset Muscular Dystrophy Allows Disease Mechanisms To Be Determined." ScienceDaily. www.sciencedaily.com/releases/2007/09/070906214953.htm (accessed July 25, 2014).

Share This




More Health & Medicine News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
Too Few Teens Receiving HPV Vaccination, CDC Says

Too Few Teens Receiving HPV Vaccination, CDC Says

Newsy (July 24, 2014) The Centers for Disease Control and Prevention is blaming doctors for the low number of children being vaccinated for HPV. Video provided by Newsy
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins