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Pomegranate Juice: Tart, Trendy, And Targeted On Prostate Cancer Cells

Date:
September 25, 2007
Source:
American Chemical Society
Summary:
Researchers in California are reporting new evidence explaining pomegranate juice's mysterious beneficial effects in fighting prostate cancer. In a new study scientists have found that the tart, trendy beverage also uses a search-and-destroy strategy to target prostate cancer cells.

Juice from the pomegranate shows promise for fighting prostate cancer.
Credit: USDA Agricultural Research Service

Researchers in California are reporting new evidence explaining pomegranate juice's mysterious beneficial effects in fighting prostate cancer.

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In a new study, Navindra Seeram and colleagues have found that the tart, trendy beverage also uses a search-and-destroy strategy to target prostate cancer cells.

In previous research, Seeram's group found that pomegranate juice consumption had a beneficial effect for prostate cancer patients with rising prostate-specific antigen (PSA) levels. Such increases in PSA signal that the cancer is progressing, "doubling time" a key indicator of prognosis. Men whose PSA levels double in a short period are more likely to die from their cancer. Pomegranate juice increased doubling times by almost fourfold.

In the new study, they researchers discovered evidence in laboratory experiments that pomegranate works in a "seek and destroy" fashion. On consumption, ellagitannins (ET), antioxidants abundant in pomegranate juice, break down to metabolites known as urolithins. The researchers showed that the urolithins concentrate at high levels in prostate tissue after being given orally and by injection to mice with prostate cancer. They also showed that urolithins inhibited the growth of human prostate cancer cells in cell culture.

"The chemopreventive potential of pomegranate ellagitannins and localization of their bioactive metabolites in mouse prostate tissue suggest that pomegranate may play a role in prostate cancer treatment and chemoprevention," the researchers state, recommending further clinical studies with pomegranate and prostate cancer patients.

This research, "Pomegranate Ellagitannin-Derived Metabolites Inhibit Prostate Cancer Growth and Localize to the Mouse Prostate Gland," is scheduled for publication in the Sept. 19 issue of ACS' Journal of Agricultural and Food Chemistry.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Cite This Page:

American Chemical Society. "Pomegranate Juice: Tart, Trendy, And Targeted On Prostate Cancer Cells." ScienceDaily. ScienceDaily, 25 September 2007. <www.sciencedaily.com/releases/2007/09/070924095856.htm>.
American Chemical Society. (2007, September 25). Pomegranate Juice: Tart, Trendy, And Targeted On Prostate Cancer Cells. ScienceDaily. Retrieved April 18, 2015 from www.sciencedaily.com/releases/2007/09/070924095856.htm
American Chemical Society. "Pomegranate Juice: Tart, Trendy, And Targeted On Prostate Cancer Cells." ScienceDaily. www.sciencedaily.com/releases/2007/09/070924095856.htm (accessed April 18, 2015).

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