Featured Research

from universities, journals, and other organizations

Scientists Spot Sneaky 'Neurodegenerative' Iron At The European Synchrotron

Date:
September 28, 2007
Source:
Public Library of Science
Summary:
Scientists suspect that iron accumulation plays a role in neurodegenerative processes such as Parkinson's disease, but its distribution in neurons has never been observed because of the lack of techniques to do so -- until today.

Scientists suspect that iron accumulation plays a role in neurodegenerative processes such as Parkinson's disease, but its distribution in neurons has never been observed because of the lack of techniques to do so. Until today.

Related Articles


Researchers from CNRS at the University of Bordeaux (France), University of Sevilla (Spain), INSERM Grenoble Institute of Neurosciences (France) and ESRF have studied the iron distribution in an in vitro model of neuronal cells that produce dopamine. Dopamine is a neurotransmitter, a chemical messenger between nerve cells in the mammalian brain. Because dopamine can form stable complexes with iron, Richard Ortega, from the cellular chemical imaging group in Bordeaux, believed that dopamine may exert a protective effect by buffering iron in dopaminergic neurons and that this system might be at fault in Parkinson's disease.

To test this hypothesis, the team used the new nanoprobe imaging experimental station recently developed at the European Synchrotron Radiation Facility to study the distribution of elements in cells. The resolution of 90 nm allowed scientists to visualize the elements distribution in the neurotransmitter vesicles. The nanoprobe consists on exciting the sample with a strongly focused X-ray beam and collecting the characteristic fluorescence signal that is re-emitted. This allows showing the different trace elements in a point, and then the sample is scanned point by point to form a complete multi-element image of the cells.

The team shows that iron is stored within dopamine vesicles inside the neuronal cells. This is the first evidence of iron-dopamine co-localization in neuro-vesicles. The results also explain that when dopamine production is obstructed, the iron in the vesicles drastically decreases. This new function of dopamine vesicles in iron storage is of critical importance to understand the molecular mechanisms involved in Parkinson's disease. In this neurological disorder, dopamine vesicular storage has been found impaired. According to these results, this would increase the levels of highly toxic iron-dopamine complexes in the neurons. The results are published in PLoS ONE on September 26.

The synchrotron nano-imaging station offers a new tool for researchers involved not only in the study of neurodegenerative diseases but also in many other fields where the determination of metal ions distribution at the subcellular level is important such as: metal toxicology, chemical carcinogenesis, and cellular pharmacology of inorganic compounds. This is one of the reasons why the team decided to submit their results in an open access journal such as PLoS ONE: " We want the different scientific communities to know that this machine is available, and the best way is by letting everyone have access to the results", explains Peter Cloetens, in charge of the station at ESRF.

Citation: Ortega R, Cloetens P, Deve's G, Carmona A, Bohic S (2007) Iron Storage within Dopamine Neurovesicles Revealed by Chemical Nano-Imaging. PLoS ONE 2(9): e925. doi:10.1371/journal.pone.0000925


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Cite This Page:

Public Library of Science. "Scientists Spot Sneaky 'Neurodegenerative' Iron At The European Synchrotron." ScienceDaily. ScienceDaily, 28 September 2007. <www.sciencedaily.com/releases/2007/09/070926191530.htm>.
Public Library of Science. (2007, September 28). Scientists Spot Sneaky 'Neurodegenerative' Iron At The European Synchrotron. ScienceDaily. Retrieved February 27, 2015 from www.sciencedaily.com/releases/2007/09/070926191530.htm
Public Library of Science. "Scientists Spot Sneaky 'Neurodegenerative' Iron At The European Synchrotron." ScienceDaily. www.sciencedaily.com/releases/2007/09/070926191530.htm (accessed February 27, 2015).

Share This


More From ScienceDaily



More Mind & Brain News

Friday, February 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Foods to Battle Stress

The Best Foods to Battle Stress

Buzz60 (Feb. 26, 2015) If you&apos;re dealing with anxiety, there are a few foods that can help. Krystin Goodwin (@krystingoodwin) has the best foods to tame stress. Video provided by Buzz60
Powered by NewsLook.com
Sleeping Too Much Or Too Little Might Increase Stroke Risk

Sleeping Too Much Or Too Little Might Increase Stroke Risk

Newsy (Feb. 26, 2015) People who sleep more than eight hours per night are 45 percent more likely to have a stroke, according to a University of Cambridge study. Video provided by Newsy
Powered by NewsLook.com
Mayor Says District of Columbia to Go Ahead With Pot Legalization

Mayor Says District of Columbia to Go Ahead With Pot Legalization

Reuters - News Video Online (Feb. 25, 2015) Washington&apos;s mayor says the District of Columbia will move forward with marijuana legalization, despite pushback from Congress. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Marijuana Nowhere Near As Deadly As Alcohol: Study

Marijuana Nowhere Near As Deadly As Alcohol: Study

Newsy (Feb. 25, 2015) A new study says marijuana is about 114 times less deadly than alcohol. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins