Featured Research

from universities, journals, and other organizations

Targeting Sugars May Revolutionize Treatment Of Bone Disorders

Date:
October 10, 2007
Source:
American Chemical Society
Summary:
One of the most fundamental scientific beliefs about the structure of human bone is apparently incomplete -- a finding scientists say could have sweeping impact on treatments for osteoporosis and other bone disorders. Their study concludes that sugars, not proteins, are key organic building blocks that account for bone's toughness and stiffness.

Researchers in the United Kingdom and Germany are reporting that one of the most fundamental scientific beliefs about the structure of human bone is incomplete -- a finding they say could have sweeping impact on treatments for osteoporosis and other bone disorders. Their study concludes that sugars, not proteins, are key organic building blocks that account for bone's toughness and stiffness.

Related Articles


The University of Cambridge's David G. Reid and Melinda Duer and Christian Jaeger at and Federal Institute of Materials Research and Testing in Berlin, explain that scientists have long held that collagen and other proteins were the main organic molecules responsible for stabilizing normal bone structure.

That belief has been the basis for existing medications for bone disorders, and bone replacement materials. At the same time, researchers paid little attention to roles of sugars (carbohydrates) in the complex process of bone growth.

In the new report, researchers describe experiments on mineralization in horse bones using an analysis tool called nuclear magnetic resonance (NMR). They found that sugars, particularly proteoglycans and glycosaminoglycans, appear to play a larger role than proteins in controlling the bone mineralization process and may be a key to maintaining healthy bones.

"This could exert a major impact on the pharmacological management of bone disorders by directing novel therapeutic approaches, as it suggests new molecular targets for drug discovery," the report states. "It also offers new disease biomarkers for diagnosis."

"Organic-Mineral Interface in Bone is Predominately Polysaccharide" is scheduled for the Oct. 16 issue of ACS' Chemistry of Materials.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Cite This Page:

American Chemical Society. "Targeting Sugars May Revolutionize Treatment Of Bone Disorders." ScienceDaily. ScienceDaily, 10 October 2007. <www.sciencedaily.com/releases/2007/10/071008093002.htm>.
American Chemical Society. (2007, October 10). Targeting Sugars May Revolutionize Treatment Of Bone Disorders. ScienceDaily. Retrieved February 27, 2015 from www.sciencedaily.com/releases/2007/10/071008093002.htm
American Chemical Society. "Targeting Sugars May Revolutionize Treatment Of Bone Disorders." ScienceDaily. www.sciencedaily.com/releases/2007/10/071008093002.htm (accessed February 27, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, February 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New FDA-Approved Diabetes Medicine Might Save Drugmaker

New FDA-Approved Diabetes Medicine Might Save Drugmaker

Newsy (Feb. 26, 2015) The U.S. Food and Drug Administration approved new diabetes drug Toujeo on Wednesday, a move that might save French drugmaker Sanofi&apos;s profits. Video provided by Newsy
Powered by NewsLook.com
The Best Foods to Battle Stress

The Best Foods to Battle Stress

Buzz60 (Feb. 26, 2015) If you&apos;re dealing with anxiety, there are a few foods that can help. Krystin Goodwin (@krystingoodwin) has the best foods to tame stress. Video provided by Buzz60
Powered by NewsLook.com
The 5 Best Tips to Look Younger Now

The 5 Best Tips to Look Younger Now

Buzz60 (Feb. 26, 2015) Life happens, and we all get older, but forget the pricey anti-aging products and plastic surgery. You can tweak your habits to turn back the hands of time. Krystin Goodwin (@krystingoodwin) has a few simple tips to help you look and feel younger. Video provided by Buzz60
Powered by NewsLook.com
Sleeping Too Much Or Too Little Might Increase Stroke Risk

Sleeping Too Much Or Too Little Might Increase Stroke Risk

Newsy (Feb. 26, 2015) People who sleep more than eight hours per night are 45 percent more likely to have a stroke, according to a University of Cambridge study. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins