Featured Research

from universities, journals, and other organizations

Potential Early Warning System For Lung Cancer Identified

Date:
October 12, 2007
Source:
BMJ-British Medical Journal
Summary:
An immune system protein could act as an early warning system for lung cancer, reveals new research. Lung cancer kills around 900,000 people every year, and can take 20 years or more to develop fully. But it is usually only picked up at an advanced stage, when the chances of successful treatment are slim.

An immune system protein could act as an early warning system for lung cancer, reveals research published ahead of print in the journal Thorax.

Lung cancer kills around 900,000 people every year, and can take 20 years or more to develop fully. But it is usually only picked up at an advanced stage, when the chances of successful treatment are slim.

As yet, there is no effective early warning system to detect the disease in its early treatable stages, and the dismal long term prospects of patients with lung cancer have changed little in the past 30 years.

The research team analysed blood (plasma) samples from 50 healthy volunteers and 104 people with different types of lung cancer.

They tested for autoantibodies - immune system proteins directed at the body's own tissues in response to specific chemical signals in the body.

They looked in particular for a panel of seven autoantibodies, which are associated with 'solid tumours,' such a lung, breast, ovarian, and prostate cancers, and triggered when cancerous changes are taking place.

They found the presence of all seven autoantibodies, and very high levels of at least one of the seven in almost eight out of 10 samples taken from patients with confirmed lung cancer.

And these autoantibodies were found in eight out of the nine patients whose cancer had not infiltrated the lymph nodes, the body's gatekeepers.

This indicates that the disease had not yet spread elsewhere and offers an 80% chance of a cure.

Only one healthy volunteer had more than one of these autoantibodies in their blood.

Other research has indicated that these autoantibodies can be picked up as early as five years before clinical symptoms start to show.

In a previous study, the researchers found abnormally high levels of specific autoantibodies in patients with breast cancer, prompting them to suggest that a test for these could be added to the screening programme. That study also showed that these autoantibodies were present before clinical symptoms appeared..

The authors argue that the lungs are especially sensitive to radiation, so repeated chest x-rays are not ideal for picking up lung cancer.

A blood test, on the other hand, is cheap compared with imaging techniques, and has no side effects. And the panel can be changed to include more or different autoantibodies for lung and other cancers.

They suggest that the blood test could be used for people at increased risk of developing the disease, such as smokers and passive smokers.

If they test positive, these people could then be referred for more detailed scans, such as computed tomography (CT) or magnetic resonance imaging (MRI), they suggest.


Story Source:

The above story is based on materials provided by BMJ-British Medical Journal. Note: Materials may be edited for content and length.


Cite This Page:

BMJ-British Medical Journal. "Potential Early Warning System For Lung Cancer Identified." ScienceDaily. ScienceDaily, 12 October 2007. <www.sciencedaily.com/releases/2007/10/071010171255.htm>.
BMJ-British Medical Journal. (2007, October 12). Potential Early Warning System For Lung Cancer Identified. ScienceDaily. Retrieved April 24, 2014 from www.sciencedaily.com/releases/2007/10/071010171255.htm
BMJ-British Medical Journal. "Potential Early Warning System For Lung Cancer Identified." ScienceDaily. www.sciencedaily.com/releases/2007/10/071010171255.htm (accessed April 24, 2014).

Share This



More Health & Medicine News

Thursday, April 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Big Pharma Braces for M&A Wave

Big Pharma Braces for M&A Wave

Reuters - Business Video Online (Apr. 22, 2014) Big pharma on the move as Novartis boss, Joe Jimenez, tells Reuters about plans to transform his company via an asset exchange with GSK, and Astra Zeneca shares surge on speculation that Pfizer is looking for a takeover. Joanna Partridge reports. Video provided by Reuters
Powered by NewsLook.com
Study Says Most Crime Not Linked To Mental Illness

Study Says Most Crime Not Linked To Mental Illness

Newsy (Apr. 22, 2014) A new study finds most crimes committed by people with mental illness are not caused by symptoms of their illness or disorder. Video provided by Newsy
Powered by NewsLook.com
Hagel Gets Preview of New High-Tech Projects

Hagel Gets Preview of New High-Tech Projects

AP (Apr. 22, 2014) Defense Secretary Chuck Hagel is given hands-on demonstrations Tuesday of some of the newest research from DARPA _ the military's Defense Advanced Research Projects Agency program. (April 22) Video provided by AP
Powered by NewsLook.com
How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins