Featured Research

from universities, journals, and other organizations

Understanding, Combating Foodborne Pathogens E. Coli And Salmonella

Date:
October 17, 2007
Source:
Kansas State University
Summary:
Understanding the ecology of two dangerous foodborne pathogens and devising ways to combat them is a big job. Researchers are taking on E. coli 0157 and salmonella. They want to answer questions like why some cattle have E. coli 0157 and some don't, and why some shed the bacteria for a longer time or at higher levels than others.

Understanding the ecology of two dangerous foodborne pathogens and devising ways to combat them is a big job. That's why Kansas State University has a team of seven researchers and six collaborators taking on E. coli 0157 and salmonella.

"It's becoming more and more difficult to study these pathogens because you have to be a jack of all trades," said T.G. Nagaraja, professor of diagnostic medicine pathobiology at K-State's College of Veterinary Medicine.

Nagaraja leads a research group that includes epidemiologists, molecular biologists, production animal medicine experts and feedlot nutritionists.

For the past five years, Nagaraja has been leading the team on an E. coli 0157 research project that goes back more than a decade at K-State. E. coli 0157 doesn't cause problems for livestock, but it's zoonotic -- that is, it can be passed on to humans through the food supply.

"Our goals are fairly simple," Nagaraja said. "We want to understand the ecology of E. coli 0157 in cattle and come up with practical, on-farm intervention strategies."

The rest of the research team includes Sanjeev Narayanan, assistant professor of pathology and molecular biology; Richard Oberst, professor of microbiology; David Renter, assistant professor in epidemiology; Mike Sanderson, associate professor of epidemiology and production animal medicine; Daniel Thomson, assistant professor of feedlot production medicine; and Ludek Zurek, associate professor of entomology.

Collaborators include K-State's Mike Apley, associate professor of production animal medicine; Jim Drouillard, professor of feedlot nutrition; Larry Hollis, professor in animal sciences and industry; Justin Kastner, assistant professor of food safety and security; and Abby Nutsch, assistant professor of food microbiology; as well as Kelly Lechtenberg, director of Midwest Veterinary Research Inc. in Oakland, Neb.

The research team is working to answer questions like why some cattle have E. coli 0157 and some don't, and why some shed the bacteria for a longer time or at higher levels than others.

The K-State researchers also want to understand why the presence of 0157 is higher during some months than in others, and why animals under stress shed more of the bacteria than other animals.

"If we find out answers to these questions, we can come up with intervention strategies," Nagaraja said. "The first part of the research is to look at the ecology, and the second part is to develop tests and practical intervention strategies."

For instance, Thomson is doing research with a company in Minnesota on a vaccine with antibodies that prevent the bacteria from getting iron, which they need to live. All three studies have shown a reduction in the prevalence of 0157 when the vaccine is used, Nagaraja said.

He also said that researchers are looking at what changes they could make in cattle diets that would make the animals' digestive systems less hospitable to 0157. Because the bacteria seem to congregate in the hindgut, Nagaraja said feeding cattle a diet that will reach the hindgut and produce acid will be effective in killing 0157. He also said that probiotics -- beneficial bacteria, like what humans can get though eating yogurt -- can reduce 0157 because they out compete the bacteria for resources.

Salmonella, one of the most common causes of gastroenteritis and which is spread through contaminated ground beef and manure-fertilized produce, also harms livestock. It causes bloody diarrhea in feedlot cattle and causes dairy cattle to abort. Renter's work centers on finding out why feedlot cattle that are being treated for other infections may show a higher rate of salmonella than healthy cattle.

To find out the serotype of the salmonella, veterinarians and researchers have to send samples to a laboratory in Iowa. Narayanan is working to develop a rapid, molecular-based testing method that is more accessible.

Nagaraja said that in the future the research team will pursue the goal of eliminating 0157 and salmonella. Although 0157 also is spread by grain-eating birds that carry the bacteria from one feedlot to another, it poses less of a challenge than salmonella. Nagaraja said that rodents and other animals that live in barns carry salmonella, so the research team hopes to at least reduce its prevalence. The research team also is studying antimicrobial resistance with the hopes of preventing foodborne pathogens from becoming more dangerous to humans and animals.

"Salmonella is notorious for becoming resistant to multiple antibiotics," Nagaraja said. "Also, it can transfer the genes that cause antibacterial resistance to other bacteria. Our primary objective is to develop a synergistic program to evaluate the role of the cattle industry on the prevalence, amplification and spread of antimicrobial resistance."


Story Source:

The above story is based on materials provided by Kansas State University. Note: Materials may be edited for content and length.


Cite This Page:

Kansas State University. "Understanding, Combating Foodborne Pathogens E. Coli And Salmonella." ScienceDaily. ScienceDaily, 17 October 2007. <www.sciencedaily.com/releases/2007/10/071016103805.htm>.
Kansas State University. (2007, October 17). Understanding, Combating Foodborne Pathogens E. Coli And Salmonella. ScienceDaily. Retrieved October 2, 2014 from www.sciencedaily.com/releases/2007/10/071016103805.htm
Kansas State University. "Understanding, Combating Foodborne Pathogens E. Coli And Salmonella." ScienceDaily. www.sciencedaily.com/releases/2007/10/071016103805.htm (accessed October 2, 2014).

Share This



More Plants & Animals News

Thursday, October 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Attacking Superbugs

Attacking Superbugs

Ivanhoe (Oct. 1, 2014) — Two weapons hospitals can use to attack superbugs. Scientists in Ireland created a new gel resistant to superbugs, and a robot that can disinfect a room in minutes. Video provided by Ivanhoe
Powered by NewsLook.com
Cultural Learning In Wild Chimps Observed For The First Time

Cultural Learning In Wild Chimps Observed For The First Time

Newsy (Oct. 1, 2014) — Cultural transmission — the passing of knowledge from one animal to another — has been caught on camera with chimps teaching other chimps. Video provided by Newsy
Powered by NewsLook.com
Earth Has Lost Half Its Vertebrate Wildlife Since 1970: WWF

Earth Has Lost Half Its Vertebrate Wildlife Since 1970: WWF

Newsy (Sep. 30, 2014) — A new study published by the World Wide Fund for Nature found that more than half of the world's wildlife population has declined since 1970. Video provided by Newsy
Powered by NewsLook.com
Annual Dog Surfing Competition Draws California Crowds

Annual Dog Surfing Competition Draws California Crowds

AFP (Sep. 30, 2014) — The best canine surfers gathered for Huntington Beach's annual dog surfing competition, "Surf City, Surf Dog." Duration: 01:15 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins