Featured Research

from universities, journals, and other organizations

High-dose Ibuprofen May Slow Cystic Fibrosis Lung Disease -- Especially In Children

Date:
October 18, 2007
Source:
John Wiley & Sons, Inc.
Summary:
The most important clinical problem for people with cystic fibrosis is inflammation of their lungs. The inflammation then plays a role in further damaging the tissues. Consequently, people have wondered whether giving non-steroidal anti-inflammatory drugs (NSAIDs) to patients with CF will reduce lung inflammation. Long-term high-dose ibuprofen may slow the rate of decline in lung function in children with cystic fibrosis when treatment is started under the age of 13.

The most important clinical problem for people with cystic fibrosis (CF) is inflammation of their lungs. The inflammation then plays a role in further damaging the tissues. Consequently, people have wondered whether giving non-steroidal anti-inflammatory drugs (NSAIDs) to patients with CF will reduce lung inflammation.

This updated Cochrane Review supports the intriguing suggestion that long-term high-dose ibuprofen slows the rate of decline in lung function in children when treatment is started under the age of 13.

The Review now includes new data from a large Canadian multi-centre study, which doubled the number of participants that the researchers could analyse, and in particular, added a large number of children. "The results now show that high-dose ibuprofen may slow down the rate at which the lung function of a child with CF deteriorates. By slowing the rate of deterioration, high-dose ibuprofen can contribute to longer and healthier lives for children with Cystic Fibrosis," said lead researcher Dr Larry Lands, who works in the Department of Pediatrics at Montreal Children's Hospital.

"High-dose ibuprofen, a relatively inexpensive treatment, requires medical supervision, but is generally well-tolerated. Further work is ongoing in my laboratory on the mechanisms of action of high-dose ibuprofen, so that more targeted and potent therapies can be developed," said Lands.

The long-term effects of prolonged use of high doses of NSAIDs have yet to be determined. This treatment is not currently recommended for routine use and patients receiving the therapy should do so under the supervision of a specialist CF Centre. However, future research could lead to real improvements in patients' lives.


Story Source:

The above story is based on materials provided by John Wiley & Sons, Inc.. Note: Materials may be edited for content and length.


Cite This Page:

John Wiley & Sons, Inc.. "High-dose Ibuprofen May Slow Cystic Fibrosis Lung Disease -- Especially In Children." ScienceDaily. ScienceDaily, 18 October 2007. <www.sciencedaily.com/releases/2007/10/071016195927.htm>.
John Wiley & Sons, Inc.. (2007, October 18). High-dose Ibuprofen May Slow Cystic Fibrosis Lung Disease -- Especially In Children. ScienceDaily. Retrieved September 22, 2014 from www.sciencedaily.com/releases/2007/10/071016195927.htm
John Wiley & Sons, Inc.. "High-dose Ibuprofen May Slow Cystic Fibrosis Lung Disease -- Especially In Children." ScienceDaily. www.sciencedaily.com/releases/2007/10/071016195927.htm (accessed September 22, 2014).

Share This



More Health & Medicine News

Monday, September 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins