Featured Research

from universities, journals, and other organizations

3-D Model Of Esophageal Cancer Created

Date:
November 21, 2007
Source:
Cold Spring Harbor Laboratory
Summary:
Scientists present an innovative new model of esophageal cancer, which holds great promise as an experimental platform to investigate the etiology and possible treatment of this devastating disease.

A team of scientists led by Dr. Anil Rustgi (UPenn) presents an innovative new model of esophageal cancer, which holds great promise as an experimental platform to investigate the etiology and possible treatment of this devastating disease.

"This model allows us to dissect the specific genetic alterations that are important in the initiation and progression of esophageal squamous cell cancer, which holds promise for sqamous cell cancers arising in other sites, such as the skin, lung, head and neck," explains Dr. Rustgi.

There are 2 main types of esophageal cancer: squamous cell carcinoma and adenocarcinoma. Esophageal squamous cell carcinoma (ESCC) is the third most common cancer of the digestive tract and the seventh leading cause of cancer-related deaths worldwide. It is a highly malignant cancer and generally carries a poor prognosis, owing to its predominantly late detection.

Dr. Rustigi and colleagues developed a tissue-engineered, organotypic 3D culture system of esophageal squamous cell cancer. They found that ESCC results from a combination of genetic mutations (namely, EGFR overexpression, hTERT activation and p53 mutation) as well as changes in the tumor microenvironment.

Dr. Rustgi emphasizes that "we have found that altering the stromal fibroblasts can influence the extent of tumor cell migration and invasion. Thus, previously underappreciated, it is the interplay of tumor cells and fibroblasts that has great meaning on how cancer arises and progresses."

This research is detailed in the November 1st issue of Genes & Development.


Story Source:

The above story is based on materials provided by Cold Spring Harbor Laboratory. Note: Materials may be edited for content and length.


Cite This Page:

Cold Spring Harbor Laboratory. "3-D Model Of Esophageal Cancer Created." ScienceDaily. ScienceDaily, 21 November 2007. <www.sciencedaily.com/releases/2007/10/071031172833.htm>.
Cold Spring Harbor Laboratory. (2007, November 21). 3-D Model Of Esophageal Cancer Created. ScienceDaily. Retrieved April 16, 2014 from www.sciencedaily.com/releases/2007/10/071031172833.htm
Cold Spring Harbor Laboratory. "3-D Model Of Esophageal Cancer Created." ScienceDaily. www.sciencedaily.com/releases/2007/10/071031172833.htm (accessed April 16, 2014).

Share This



More Health & Medicine News

Wednesday, April 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Outbreak Now Linked To 121 Deaths

Ebola Outbreak Now Linked To 121 Deaths

Newsy (Apr. 15, 2014) The ebola virus outbreak in West Africa is now linked to 121 deaths. Health officials fear the virus will continue to spread in urban areas. Video provided by Newsy
Powered by NewsLook.com
Cognitive Function: Is It All Downhill From Age 24?

Cognitive Function: Is It All Downhill From Age 24?

Newsy (Apr. 15, 2014) A new study out of Canada says cognitive motor performance begins deteriorating around age 24. Video provided by Newsy
Powered by NewsLook.com
How Mt. Everest Helped Scientists Research Diabetes

How Mt. Everest Helped Scientists Research Diabetes

Newsy (Apr. 15, 2014) British researchers were able to use Mount Everest's low altitudes to study insulin resistance. They hope to find ways to treat diabetes. Video provided by Newsy
Powered by NewsLook.com
Carpenter's Injury Leads To Hundreds Of 3-D-Printed Hands

Carpenter's Injury Leads To Hundreds Of 3-D-Printed Hands

Newsy (Apr. 14, 2014) Richard van As lost all fingers on his right hand in a woodworking accident. Now, he's used the incident to create a prosthetic to help hundreds. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins