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3-D Model Of Esophageal Cancer Created

Date:
November 21, 2007
Source:
Cold Spring Harbor Laboratory
Summary:
Scientists present an innovative new model of esophageal cancer, which holds great promise as an experimental platform to investigate the etiology and possible treatment of this devastating disease.
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A team of scientists led by Dr. Anil Rustgi (UPenn) presents an innovative new model of esophageal cancer, which holds great promise as an experimental platform to investigate the etiology and possible treatment of this devastating disease.

"This model allows us to dissect the specific genetic alterations that are important in the initiation and progression of esophageal squamous cell cancer, which holds promise for sqamous cell cancers arising in other sites, such as the skin, lung, head and neck," explains Dr. Rustgi.

There are 2 main types of esophageal cancer: squamous cell carcinoma and adenocarcinoma. Esophageal squamous cell carcinoma (ESCC) is the third most common cancer of the digestive tract and the seventh leading cause of cancer-related deaths worldwide. It is a highly malignant cancer and generally carries a poor prognosis, owing to its predominantly late detection.

Dr. Rustigi and colleagues developed a tissue-engineered, organotypic 3D culture system of esophageal squamous cell cancer. They found that ESCC results from a combination of genetic mutations (namely, EGFR overexpression, hTERT activation and p53 mutation) as well as changes in the tumor microenvironment.

Dr. Rustgi emphasizes that "we have found that altering the stromal fibroblasts can influence the extent of tumor cell migration and invasion. Thus, previously underappreciated, it is the interplay of tumor cells and fibroblasts that has great meaning on how cancer arises and progresses."

This research is detailed in the November 1st issue of Genes & Development.


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The above post is reprinted from materials provided by Cold Spring Harbor Laboratory. Note: Materials may be edited for content and length.


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Cold Spring Harbor Laboratory. "3-D Model Of Esophageal Cancer Created." ScienceDaily. ScienceDaily, 21 November 2007. <www.sciencedaily.com/releases/2007/10/071031172833.htm>.
Cold Spring Harbor Laboratory. (2007, November 21). 3-D Model Of Esophageal Cancer Created. ScienceDaily. Retrieved August 2, 2015 from www.sciencedaily.com/releases/2007/10/071031172833.htm
Cold Spring Harbor Laboratory. "3-D Model Of Esophageal Cancer Created." ScienceDaily. www.sciencedaily.com/releases/2007/10/071031172833.htm (accessed August 2, 2015).

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