Featured Research

from universities, journals, and other organizations

Gene Expression Profiling Of Dengue Virus Infection In Cell Lines And Patients

Date:
November 10, 2007
Source:
Public Library of Science
Summary:
Researchers have identified new host genes associated with dengue virus infection, which may open new avenues to developing a drug to treat the disease. The results suggest that drugs that target the host pathways may prove effective against dengue.

Researchers at the Novartis Institute for Tropical Diseases and the Genome Institute of Singapore have identified new host genes associated with dengue virus infection, which may open new avenues to developing a drug to treat the disease.

Related Articles


Dengue is the most prevalent mosquito-born viral disease affecting humans. Dengue-related disease results in an estimated 50-100 million cases of dengue fever and 250,000 to 500,000 cases of dengue hemorrhagic fever/dengue shock syndrome each year. Yet there is, at present, no drug treatment at all for the disease nor are there any validated host targets for therapeutic intervention.

Using microarray technology to monitor the response of virtually every human gene, Dr Subhash Vasudevan and Dr. Martin Hibberd's team aimed to identify the ways in which humans interact with dengue virus during infection in order to discover new treatment targets that could be exploited to control viral replication.

From the activated genes, the researchers identified three pathways common to in vitro and in vivo infection; the NF-kappaB initiated immune pathway, the type I interferon pathway, and the ubiquitin proteasome pathway. They next found that inhibiting the ubiquitin proteasome pathway, or activating the type I interferon pathway, resulted in significant inhibition of viral replication whereas inhibiting the NF-kappaB initiated immune pathway had no effect on viral replication. These results suggest that drugs that target the host pathways may prove effective against dengue.

Journal reference: Fink J, Gu F, Ling L, Tolfvenstam T, Olfat F, et al. (2007) Host Gene Expression Profiling of Dengue Virus Infection in Cell Lines and Patients. PLoS Negl Trop Dis 1(2): e86. doi:10.1371/journal.pntd.0000086


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Cite This Page:

Public Library of Science. "Gene Expression Profiling Of Dengue Virus Infection In Cell Lines And Patients." ScienceDaily. ScienceDaily, 10 November 2007. <www.sciencedaily.com/releases/2007/11/071107074335.htm>.
Public Library of Science. (2007, November 10). Gene Expression Profiling Of Dengue Virus Infection In Cell Lines And Patients. ScienceDaily. Retrieved October 30, 2014 from www.sciencedaily.com/releases/2007/11/071107074335.htm
Public Library of Science. "Gene Expression Profiling Of Dengue Virus Infection In Cell Lines And Patients." ScienceDaily. www.sciencedaily.com/releases/2007/11/071107074335.htm (accessed October 30, 2014).

Share This



More Plants & Animals News

Thursday, October 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Galapagos Tortoises Bounce Back, But Ecosystem Lags

Galapagos Tortoises Bounce Back, But Ecosystem Lags

Newsy (Oct. 29, 2014) The Galapagos tortoise has made a stupendous recovery from the brink of extinction to a population of more than 1,000. But it still faces threats. Video provided by Newsy
Powered by NewsLook.com
Can Drinking Milk Lead To Early Death?

Can Drinking Milk Lead To Early Death?

Newsy (Oct. 29, 2014) Researchers in Sweden released a study showing heavy milk drinkers face an increased mortality risk from a variety of causes. Video provided by Newsy
Powered by NewsLook.com
Obama: The US Will Not 'run and Hide' From Ebola

Obama: The US Will Not 'run and Hide' From Ebola

AP (Oct. 29, 2014) Surrounded by health care workers in the White House East Room, President Barack Obama said the U.S. will likely see additional Ebola cases in the weeks ahead. But he said the nation can't seal itself off in the fight against the disease. (Oct. 29) Video provided by AP
Powered by NewsLook.com
Oatmeal Healthy Recipes and Benefits

Oatmeal Healthy Recipes and Benefits

Buzz60 (Oct. 29, 2014) Oatmeal is a fantastic way to start your day. Whichever way you prepare them, oats provide your body with many health benefits. In celebration of National Oatmeal Day, Krystin Goodwin (@krystingoodwin) has a few recipe ideas, and tips on how to kickstart your day with this wholesome snack! Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins