Featured Research

from universities, journals, and other organizations

Tocilizumab Appears Safe And Effective In Treating Rheumatoid Arthritis, Study Suggests

Date:
November 14, 2007
Source:
American College of Rheumatology
Summary:
Phase III testing shows that a potential new therapy called tocilizumab is safe and effective in the treatment of rheumatoid arthritis, according to new research An estimated 2.1 million Americans have RA, most of them women.

Phase III testing shows that a potential new therapy called tocilizumab is safe and effective in the treatment of rheumatoid arthritis, according to research presented recently at the American College of Rheumatology Annual Scientific Meeting in Boston, Mass.

Rheumatoid arthritis is a chronic disease that causes pain, stiffness, swelling, and limitation in the motion and function of multiple joints. Though joints are the principal body parts affected by RA, inflammation can develop in other organs as well. An estimated 2.1 million Americans have RA, most of them women.

Researchers tested the effectiveness and safety of tocilizumab, a new humanized, anti-human IL-6 receptor antibody, in patients with moderate to severe active RA despite being treated with methotrexate. Tocilizumab blocks the function of interleukin-6, a molecule that plays a fundamental role in maintaining the inflammation that affects patients with RA.

623 participants in this double-blind, placebo-controlled, phase three trial were randomly given 8 mg/kg of tocilizumab, 4 mg/kg of tocilizumab, or placebo intravenously every four weeks for twenty-four weeks. All participants received weekly doses of methotrexate throughout the study. No other disease-modifying anti-rheumatic drugs, or DMARDS, were allowed.

Researchers found that a significantly higher proportion of patients treated with tocilizumab showed improvements in the primary endpoint (ACR 20 at 24 weeks). The ACR 20 response was achieved by 59 and 48 percent of patients receiving tocilizumab at 8 and 4mg/kg, respectively, compared to 27 percent on placebo. The more stringent ACR 70 response was achieved by 22 percent of patients treated with 8mg/kg tocilizumab, but only two percent of patients receiving placebo.

The ACR 20/50/70 scoring criteria measures improvement in tender and swollen joint count and improvement in at least three of the following five criteria: pain; level of disability; overall self-assessment; overall physician assessment; and level of acute phase reactants (including the C-reactive protein or sedimentation rate).

Adverse events were similar across all groups of participants. Of 41 serious adverse events affecting approximately six percent of participants in each group, 15 were considered related to the study treatment and 11 led to discontinuation of treatment. Serious infections were observed more often in the participants treated with tocilizumab than the placebo group (2.9 percent in the 8 mg/kg group, 1.4 percent in the 4 mg/kg group, and 1 percent in the placebo group).

“The data prove that IL-6 is importantly involved in the inflammatory response of RA, and that targeting the IL-6 receptor with tocilizumab is a useful novel treatment modality,” said Josef Smolen, MD; professor of medicine; chairman, department of internal Medicine III and division of rheumatology; Medical University of Vienna; Chairman, 2nd department of medicine, Hietzing Hospital; Vienna, Austria; and an investigator in the study.


Story Source:

The above story is based on materials provided by American College of Rheumatology. Note: Materials may be edited for content and length.


Cite This Page:

American College of Rheumatology. "Tocilizumab Appears Safe And Effective In Treating Rheumatoid Arthritis, Study Suggests." ScienceDaily. ScienceDaily, 14 November 2007. <www.sciencedaily.com/releases/2007/11/071109204734.htm>.
American College of Rheumatology. (2007, November 14). Tocilizumab Appears Safe And Effective In Treating Rheumatoid Arthritis, Study Suggests. ScienceDaily. Retrieved September 23, 2014 from www.sciencedaily.com/releases/2007/11/071109204734.htm
American College of Rheumatology. "Tocilizumab Appears Safe And Effective In Treating Rheumatoid Arthritis, Study Suggests." ScienceDaily. www.sciencedaily.com/releases/2007/11/071109204734.htm (accessed September 23, 2014).

Share This



More Health & Medicine News

Tuesday, September 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Costs Keep Mounting

Ebola Costs Keep Mounting

Reuters - Business Video Online (Sep. 23, 2014) The WHO has warned up to 20,000 people could be infected with Ebola over the next few weeks. As Sonia Legg reports, the implications for the West African countries suffering from the disease are huge. Video provided by Reuters
Powered by NewsLook.com
Ebola Cases Could Reach 1.4 Million Within 4 Months

Ebola Cases Could Reach 1.4 Million Within 4 Months

Newsy (Sep. 23, 2014) Health officials warn that without further intervention, the number of Ebola cases in Liberia and Sierra Leone could reach 1.4 million by January. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Cases to Triple in Weeks Without Drastic Action

WHO: Ebola Cases to Triple in Weeks Without Drastic Action

AFP (Sep. 23, 2014) The number of Ebola infections will triple to 20,000 by November, soaring by thousands every week if efforts to stop the outbreak are not stepped up radically, the WHO warned in a study on Tuesday. Duration: 01:01 Video provided by AFP
Powered by NewsLook.com
5 Ways Men Can Prevent Most Heart Attacks

5 Ways Men Can Prevent Most Heart Attacks

Newsy (Sep. 23, 2014) No surprise here: A recent study says men can reduce their risk of heart attack by maintaining a healthy lifestyle, which includes daily exercise. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins