Featured Research

from universities, journals, and other organizations

Genetic Selection Of Target Stem Cell Populations

Date:
December 2, 2007
Source:
University of Nottingham
Summary:
Human embryonic stem cells can be genetically manipulated to help select out desirable cell types, according to a new study. This advance could help scientists develop better ways of deriving useful cell populations for therapeutic and research purposes. Although human embryonic stem cells can theoretically become any kind of cell in the body, directing this differentiation and selecting for a particular cell type is challenging.

Human embryonic stem cells can be genetically manipulated to help select out desirable cell types, according to a University of Nottingham study published online in Molecular Therapy.

Related Articles


This advance could help scientists develop better ways of deriving useful cell populations for therapeutic and research purposes.

Although human embryonic stem cells (hESCs) can theoretically become any kind of cell in the body, directing this differentiation and selecting for a particular cell type is challenging.

Dr Chris Denning and his team at The University of Nottingham manipulated certain genetic targets in their stem cells to enhance the selection of heart muscle cells from other cell types present in their culture.

They increased the percentage of heart muscle cells present to as much as ninety-one percent by selecting out fast dividing cells and selecting for cells that expressed genes characteristic of these slower dividing cardiac cells.

According to the authors, this strategy could be easily manipulated to select for other cell types. This paper is one of the first to document the successful selection of one kind of cell in hESCs — an important step towards realizing their potential.

Dr Denning, of the Wolfson Centre for Stem Cells, Tissue Engineering and Modelling (STEM) at The University of Nottingham, said: “Human embryonic stem cells are remarkable because we can keep them at a primitive stage of development for a long time in the laboratory, and yet by changing their environment we can also coax them into becoming virtually any cell type within the human body.

“This includes beating heart cells, also known as cardiomyocytes. In the longer term, cardiomyocytes could be used for testing the safety of new pharmaceutical products or for transplanting into patients hearts after heart attack. The trouble is that these uses will require pure populations of cardiomyocytes but until now whenever we have produced cardiomyocytes, we have also produced many other unwanted 'contaminating' cell types such as brain cells or liver cells.

“What we describe in the present research is a method to eliminate the unwanted cells and produce almost pure populations of cardiomyocytes.

“There is still a lot of work to be done, but this really does provide a first step towards being able to use cardiomyocytes derived from human embryonic stem cells for important clinical applications.”


Story Source:

The above story is based on materials provided by University of Nottingham. Note: Materials may be edited for content and length.


Cite This Page:

University of Nottingham. "Genetic Selection Of Target Stem Cell Populations." ScienceDaily. ScienceDaily, 2 December 2007. <www.sciencedaily.com/releases/2007/11/071130224755.htm>.
University of Nottingham. (2007, December 2). Genetic Selection Of Target Stem Cell Populations. ScienceDaily. Retrieved November 23, 2014 from www.sciencedaily.com/releases/2007/11/071130224755.htm
University of Nottingham. "Genetic Selection Of Target Stem Cell Populations." ScienceDaily. www.sciencedaily.com/releases/2007/11/071130224755.htm (accessed November 23, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, November 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

AFP (Nov. 23, 2014) The arable district of Kenema in Sierra Leone -- at the centre of the Ebola outbreak in May -- has been under quarantine for three months as the cocoa harvest comes in. Duration: 01:32 Video provided by AFP
Powered by NewsLook.com
WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com
Raw: Paralyzed Marine Walks With Robotic Braces

Raw: Paralyzed Marine Walks With Robotic Braces

AP (Nov. 21, 2014) Marine Corps officials say a special operations officer left paralyzed by a sniper's bullet in Afghanistan walked using robotic leg braces in a ceremony to award him a Bronze Star. (Nov. 21) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins