Featured Research

from universities, journals, and other organizations

Sedative May Have Better Outcomes Than Common Medication For ICU Patients On Respirator

Date:
December 12, 2007
Source:
JAMA and Archives Journals
Summary:
Intensive care unit patients on respirators who were sedated with the drug dexmedetomidine had more days alive without delirium or coma and better sedation compared to patients treated with the recommended drug lorazepam, according to a study in the Dec. 12 issue of JAMA.

Intensive care unit patients on respirators who were sedated with the drug dexmedetomidine had more days alive without delirium or coma and better sedation compared to patients treated with the recommended drug lorazepam, according to a study in the December 12 issue of JAMA.

Benzodiazepine drugs, such as lorazepam, are routinely administered to mechanically ventilated (respirators) patients to reduce pain and anxiety and to allow patients to tolerate invasive procedures in the intensive care unit (ICU). But these medications may also increase mechanical ventilation time, ICU length of stay and the risk of developing acute brain dysfunction, i.e., delirium and coma, according to background information in the article. The medication dexmedetomidine induces sedation via different central nervous system receptors than the benzodiazepine drugs and may lower the risk of acute brain dysfunction.

Pratik P. Pandharipande, M.D., M.S.C.I., of Vanderbilt University Schools of Medicine and Nursing, Nashville, Tenn., and colleagues conducted a study to determine if dexmedetomidine, when compared with benzodiazepine drugs, reduces the duration of delirium and coma while effectively sedating mechanically ventilated ICU patients. The randomized controlled trial included 106 adult ICU patients who were mechanically ventilated between August 2004 and April 2006. Patients were sedated with dexmedetomidine or lorazepam for as many as 120 hours.

The researchers found that dexmedetomidine patients had more days alive without delirium or coma (median [midpoint], 7 vs. 3). About 30 percent fewer patients experienced coma in the dexmedetomidine group than in the lorazepam group (63 percent vs. 92 percent). Nonsignificant differences were noted between the dexmedetomidine and lorazepam groups in death at 28-days (17 percent vs. 27 percent) and ventilator-free days (22 days vs. 18 days alive and free of mechanical ventilation).

A higher but nonsignificant percentage of patients in the dexmedetomidine group were able to complete post-ICU neuropsychological testing. Patients administered dexmedetomidine spent more time near the targeted level of sedation compared with patients sedated with lorazepam (median percentage of days, 80 percent vs. 67 percent). The 12-month time to death in the dexmedetomidine vs. the lorazepam group was 363 vs. 188 days, respectively.

"In this double-blind, randomized controlled trial, dexmedetomidine was more effective than lorazepam for achieving sustained sedation of mechanically ventilated medical and surgical ICU patients. Dexmedetomidine-treated ICU patients had 4 more days alive and without delirium or coma, significantly higher accuracy at meeting the stated sedation goals, and no added cost of care, as measured using data obtained at the largest enrolling site," the authors conclude.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Cite This Page:

JAMA and Archives Journals. "Sedative May Have Better Outcomes Than Common Medication For ICU Patients On Respirator." ScienceDaily. ScienceDaily, 12 December 2007. <www.sciencedaily.com/releases/2007/12/071211234055.htm>.
JAMA and Archives Journals. (2007, December 12). Sedative May Have Better Outcomes Than Common Medication For ICU Patients On Respirator. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2007/12/071211234055.htm
JAMA and Archives Journals. "Sedative May Have Better Outcomes Than Common Medication For ICU Patients On Respirator." ScienceDaily. www.sciencedaily.com/releases/2007/12/071211234055.htm (accessed July 25, 2014).

Share This




More Health & Medicine News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
Too Few Teens Receiving HPV Vaccination, CDC Says

Too Few Teens Receiving HPV Vaccination, CDC Says

Newsy (July 24, 2014) The Centers for Disease Control and Prevention is blaming doctors for the low number of children being vaccinated for HPV. Video provided by Newsy
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins